Annual Operating Margin:
-67.38%-22.47%(-50.03%)Summary
- As of today, IONS annual operating profit margin is -67.38%, with the most recent change of -22.47% (-50.03%) on December 31, 2024.
- During the last 3 years, IONS annual operating margin has fallen by -65.56% (-3602.20%).
- IONS annual operating margin is now -306.75% below its all-time high of 32.59%, reached on December 31, 2019.
Performance
IONS Operating Margin Chart
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Range
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Quarterly Operating Margin:
30.93%+142.52%(+127.72%)Summary
- As of today, IONS quarterly operating profit margin is 30.93%, with the most recent change of +142.52% (+127.72%) on June 30, 2025.
- Over the past year, IONS quarterly operating margin has increased by +60.27% (+205.42%).
- IONS quarterly operating margin is now -41.42% below its all-time high of 52.80%, reached on December 31, 2019.
Performance
IONS Quarterly Operating Margin Chart
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Operating Margin Formula
Operating Profit Margin = Operating Profit
Revenue ✕ 100%
Revenue ✕ 100%
IONS Operating Margin Trends
| PeriodPeriod | AnnualAnnual | QuarterlyQuarterly |
|---|---|---|
| 1Y1 Year | -50.0% | +205.4% |
| 3Y3 Years | -3602.2% | +148.4% |
| 5Y5 Years | -306.8% | +187.0% |
IONS Operating Margin Highs & Lows
| PeriodPeriod | Annual vs HighAnnual vs High | Annual vs LowAnnual vs Low | Quarter. vs HighQuarter. vs High | Quarter. vs LowQuarter. vs Low | |
|---|---|---|---|---|---|
| 3Y | 3-Year | -3602.2% | +3.5% | at high | +122.6% |
| 5Y | 5-Year | -306.8% | +3.5% | -38.4% | +122.6% |
| All-Time | All-Time | -306.8% | +84.8% | -41.4% | +102.5% |
IONS Operating Margin History
| Date | Annual | Quarterly |
|---|---|---|
| Jun 2025 | - | 30.93%(+127.7%) |
| Mar 2025 | - | -111.59%(-130.3%) |
| Dec 2024 | -67.38%(-50.0%) | -48.46%(+56.4%) |
| Sep 2024 | - | -111.09%(-278.6%) |
| Jun 2024 | - | -29.34%(+76.6%) |
| Mar 2024 | - | -125.12%(-6663.2%) |
| Dec 2023 | -44.91%(+35.7%) | -1.85%(+98.1%) |
| Sep 2023 | - | -99.35%(-107.5%) |
| Jun 2023 | - | -47.87%(+45.3%) |
| Mar 2023 | - | -87.45%(+36.1%) |
| Dec 2022 | -69.84%(-3737.4%) | -136.84%(-269.5%) |
| Sep 2022 | - | -37.03%(+42.1%) |
| Jun 2022 | - | -63.92%(-57.7%) |
| Mar 2022 | - | -40.52%(-180.7%) |
| Dec 2021 | -1.82%(+91.1%) | 50.23%(+177.9%) |
| Sep 2021 | - | -64.50%(-11.1%) |
| Jun 2021 | - | -58.03%(+29.6%) |
| Mar 2021 | - | -82.41%(-939.2%) |
| Dec 2020 | -20.56%(-163.1%) | -7.93%(+65.2%) |
| Sep 2020 | - | -22.82%(+35.8%) |
| Jun 2020 | - | -35.56%(+22.4%) |
| Mar 2020 | - | -45.83%(-186.8%) |
| Dec 2019 | 32.59%(+418.6%) | 52.80%(+3420.0%) |
| Sep 2019 | - | 1.50%(+113.1%) |
| Jun 2019 | - | -11.49%(-128.1%) |
| Mar 2019 | - | 40.89%(+628.9%) |
| Dec 2018 | -10.23%(-269.4%) | 5.61%(+143.9%) |
| Sep 2018 | - | -12.77%(+70.1%) |
| Jun 2018 | - | -42.70%(-1764.6%) |
| Mar 2018 | - | -2.29%(+38.1%) |
| Dec 2017 | 6.04%(+211.6%) | -3.70%(-138.7%) |
| Sep 2017 | - | 9.56%(+66.6%) |
| Jun 2017 | - | 5.74%(-65.9%) |
| Mar 2017 | - | 16.83%(-34.4%) |
| Dec 2016 | -5.41%(+79.7%) | 25.67%(+69.4%) |
| Sep 2016 | - | 15.15%(+111.9%) |
| Jun 2016 | - | -126.92%(+13.7%) |
| Mar 2016 | - | -147.13%(-20.5%) |
| Dec 2015 | -26.70%(-19.8%) | -122.05%(-24.5%) |
| Sep 2015 | - | -98.00%(-364.4%) |
| Jun 2015 | - | 37.07%(+348.6%) |
| Mar 2015 | - | -14.91%(-225.5%) |
| Dec 2014 | -22.29%(+36.5%) | 11.88%(+124.4%) |
| Sep 2014 | - | -48.78%(-318.7%) |
| Jun 2014 | - | -11.65%(+88.9%) |
| Mar 2014 | - | -105.35%(-124.1%) |
| Dec 2013 | -35.08%(+48.1%) | -47.00%(+56.5%) |
| Sep 2013 | - | -108.14%(-419.7%) |
| Jun 2013 | - | -20.81%(-654.9%) |
| Mar 2013 | - | 3.75%(+102.9%) |
| Dec 2012 | -67.54%(+5.9%) | -130.66%(+45.2%) |
| Sep 2012 | - | -238.51%(-2977.1%) |
| Jun 2012 | - | 8.29%(+109.8%) |
| Mar 2012 | - | -84.33%(-64.8%) |
| Dec 2011 | -71.76%(-61.0%) | -51.17%(+52.2%) |
| Sep 2011 | - | -106.95%(-91.8%) |
| Jun 2011 | - | -55.76%(+21.1%) |
| Mar 2011 | - | -70.67%(-17.7%) |
| Dec 2010 | -44.58%(-96.8%) | -60.02%(-106.2%) |
| Sep 2010 | - | -29.11%(+62.7%) |
| Jun 2010 | - | -78.10%(-385.7%) |
| Mar 2010 | - | -16.08%(+55.6%) |
| Dec 2009 | -22.65%(-86.0%) | -36.18%(+6.8%) |
| Sep 2009 | - | -38.83%(-149.2%) |
| Jun 2009 | - | -15.58%(-667.5%) |
| Mar 2009 | - | -2.03%(-113.0%) |
| Dec 2008 | -12.18% | 15.62%(+216.4%) |
| Sep 2008 | - | -13.42%(-41.1%) |
| Jun 2008 | - | -9.51%(+77.0%) |
| Date | Annual | Quarterly |
|---|---|---|
| Mar 2008 | - | -41.36%(-21.1%) |
| Dec 2007 | -56.42%(+87.3%) | -34.14%(+75.6%) |
| Sep 2007 | - | -139.69%(+72.9%) |
| Jun 2007 | - | -515.60%(+39.6%) |
| Mar 2007 | - | -853.10%(-506.1%) |
| Dec 2006 | -442.52%(-253.6%) | -140.76%(+75.3%) |
| Sep 2006 | - | -570.03%(-44.0%) |
| Jun 2006 | - | -395.82%(-22.8%) |
| Mar 2006 | - | -322.31%(-422.5%) |
| Dec 2005 | -125.14%(+37.6%) | -61.69%(+63.2%) |
| Sep 2005 | - | -167.51%(-44.6%) |
| Jun 2005 | - | -115.87%(+47.5%) |
| Mar 2005 | - | -220.68%(-29.7%) |
| Dec 2004 | -200.42%(-29.8%) | -170.14%(+32.3%) |
| Sep 2004 | - | -251.25%(+0.1%) |
| Jun 2004 | - | -251.56%(-38.6%) |
| Mar 2004 | - | -181.54%(+18.0%) |
| Dec 2003 | -154.38%(-150.4%) | -221.47%(-31.2%) |
| Sep 2003 | - | -168.82%(-43.1%) |
| Jun 2003 | - | -117.99%(+12.8%) |
| Mar 2003 | - | -135.28%(-199.5%) |
| Dec 2002 | -61.66%(+28.7%) | -45.17%(+47.6%) |
| Sep 2002 | - | -86.25%(-40.2%) |
| Jun 2002 | - | -61.51%(-13.7%) |
| Mar 2002 | - | -54.11%(-121.9%) |
| Dec 2001 | -86.54%(-11.2%) | - |
| Sep 2001 | - | -24.38%(+88.8%) |
| Jun 2001 | - | -216.86%(+41.7%) |
| Mar 2001 | - | -371.98%(-212.3%) |
| Dec 2000 | -77.82%(+38.8%) | -119.10%(-6239.2%) |
| Sep 2000 | - | 1.94%(+101.7%) |
| Jun 2000 | - | -117.04%(+56.9%) |
| Mar 2000 | - | -271.56%(-107.0%) |
| Dec 1999 | -127.14%(-53.3%) | -131.18%(-73.5%) |
| Sep 1999 | - | -75.59%(+54.5%) |
| Jun 1999 | - | -166.16%(-3.5%) |
| Mar 1999 | - | -160.51%(+46.3%) |
| Dec 1998 | -82.91%(+13.4%) | -298.76%(-3176.8%) |
| Sep 1998 | - | 9.71%(+105.8%) |
| Jun 1998 | - | -166.64%(-17.0%) |
| Mar 1998 | - | -142.45%(-32.8%) |
| Dec 1997 | -95.72%(+25.3%) | -107.29%(-420.1%) |
| Sep 1997 | - | -20.63%(+87.7%) |
| Jun 1997 | - | -167.24%(+13.6%) |
| Mar 1997 | - | -193.48%(-32.4%) |
| Dec 1996 | -128.19%(+34.9%) | -146.15%(-11.3%) |
| Sep 1996 | - | -131.37%(+23.8%) |
| Jun 1996 | - | -172.34%(-129.8%) |
| Mar 1996 | - | -75.00%(+58.9%) |
| Dec 1995 | -196.92%(+11.6%) | -182.35%(+8.8%) |
| Sep 1995 | - | -200.00%(-10.0%) |
| Jun 1995 | - | -181.82%(+22.5%) |
| Mar 1995 | - | -234.62%(-50.2%) |
| Dec 1994 | -222.77%(-47.3%) | - |
| Sep 1994 | - | -156.25%(-0.9%) |
| Jun 1994 | - | -154.84%(+10.5%) |
| Mar 1994 | - | -173.08%(-14.1%) |
| Dec 1993 | -151.24%(+39.1%) | -151.72%(-13.8%) |
| Sep 1993 | - | -133.33%(+7.2%) |
| Jun 1993 | - | -143.75%(+23.9%) |
| Mar 1993 | - | -188.89%(+84.7%) |
| Dec 1992 | -248.28%(-49.0%) | -1233.33%(-730.6%) |
| Sep 1992 | - | -148.48%(+18.7%) |
| Jun 1992 | - | -182.61%(+8.7%) |
| Mar 1992 | - | -200.00%(+68.0%) |
| Dec 1991 | -166.67%(+25.9%) | -625.00%(-420.8%) |
| Sep 1991 | - | -120.00%(+21.7%) |
| Jun 1991 | - | -153.33%(-76.9%) |
| Mar 1991 | - | -86.67%(+92.8%) |
| Dec 1990 | -225.00% | -1200.00% |
FAQ
- What is Ionis Pharmaceuticals, Inc. annual operating profit margin?
- What is the all-time high annual operating margin for Ionis Pharmaceuticals, Inc.?
- What is Ionis Pharmaceuticals, Inc. annual operating margin year-on-year change?
- What is Ionis Pharmaceuticals, Inc. quarterly operating profit margin?
- What is the all-time high quarterly operating margin for Ionis Pharmaceuticals, Inc.?
- What is Ionis Pharmaceuticals, Inc. quarterly operating margin year-on-year change?
What is Ionis Pharmaceuticals, Inc. annual operating profit margin?
The current annual operating margin of IONS is -67.38%
What is the all-time high annual operating margin for Ionis Pharmaceuticals, Inc.?
Ionis Pharmaceuticals, Inc. all-time high annual operating profit margin is 32.59%
What is Ionis Pharmaceuticals, Inc. annual operating margin year-on-year change?
Over the past year, IONS annual operating profit margin has changed by -22.47% (-50.03%)
What is Ionis Pharmaceuticals, Inc. quarterly operating profit margin?
The current quarterly operating margin of IONS is 30.93%
What is the all-time high quarterly operating margin for Ionis Pharmaceuticals, Inc.?
Ionis Pharmaceuticals, Inc. all-time high quarterly operating profit margin is 52.80%
What is Ionis Pharmaceuticals, Inc. quarterly operating margin year-on-year change?
Over the past year, IONS quarterly operating profit margin has changed by +60.27% (+205.42%)