Annual Operating Margin
-67.38%22.47%-50.03%
Summary
- Current Value
- As of today, IONS annual operating margin is -67.38%, down -50.03% on
- Historical Performance
- IONS annual operating margin is down -3602.20% over the past 3 years, and down -306.75% over the past 5 years
- All-Time High Comparison
- IONS annual operating margin is currently -306.75% below its historical high of 32.59% set on
- 3-Year Low Comparison
- IONS annual operating margin is +3.52% above its 3-year low of -69.84% reached on an earlier date
- Sector Comparison
- IONS annual operating margin is higher than 46.25% of companies in Healthcare sector
Operating Margin Chart
Add series to chart1/6
Series
SUGGESTED SERIES
Performance
| Metric | Date | Value | 1Y | 3Y | 5Y | 15Y |
|---|---|---|---|---|---|---|
| Annual Operating Margin | -67.38% | -50.0% | -3602.2% | -306.8% | -197.5% | |
| Quarterly Operating Margin | -102.21% | +8.0% | -176.0% | -347.9% | -251.1% | |
| Price | $79.48 | +127.5% | +99.5% | +33.2% | +700.4% | |
| PE Ratio | - | – | – | – | – | |
| Annual Revenue | $705.14M | -10.5% | -13.0% | -37.2% | +479.9% | |
| Annual Operating Profit | -$475.11M | -34.3% | -3123.5% | -229.8% | -1625.3% | |
| Annual Gross Margin | 95.29% | -0.7% | -1.0% | -2.9% | +100.0% | |
| Annual Net Margin | -64.37% | -38.4% | -1723.5% | -336.4% | -123.9% |
Operating Margin Highs
| Period | High | Date | Current |
|---|---|---|---|
| 3Y | -44.91% | -50.0% | |
| 5Y | -1.82% | -3602.2% | |
| All | 32.59% | -306.8% |
Operating Margin Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 3Y | -69.84% | N/A | +3.5% |
| 5Y | -69.84% | +3.5% | |
| All | -442.52% | +84.8% |
Operating Margin History
FAQ
What is the current annual operating margin of IONS?
As of today, IONS annual operating margin is -67.38%
What is 1-year change in IONS annual operating margin?
IONS annual operating margin is down -50.03% year-over-year
What is 3-year change in IONS annual operating margin?
IONS annual operating margin is down -3602.20% over the past 3 years
How far is IONS annual operating margin from its all-time high?
IONS annual operating margin is currently -306.75% below its historical high of 32.59% set on December 31, 2019
How does IONS annual operating margin rank versus sector peers?
IONS annual operating margin is higher than 46.25% of companies in Healthcare sector
When is IONS next annual earnings release?
The next annual earnings release for IONS is on
Quarterly Operating Margin
-102.21%133.14%-430.46%
Summary
- Current Value
- As of today, IONS quarterly operating margin is -102.21%, down -430.46% on
- Historical Performance
- IONS quarterly operating margin is up +7.99% year-over-year, and down -176.02% over the past 3 years
- All-Time High Comparison
- IONS quarterly operating margin is currently -293.58% below its historical high of 52.80% set on
- 3-Year Low Comparison
- IONS quarterly operating margin is +25.31% above its 3-year low of -136.84% reached on an earlier date
- Sector Comparison
- IONS quarterly operating margin is higher than 36.77% of companies in Healthcare sector
Performance
| Metric | Date | Value | 3M | 1Y | 3Y | 5Y |
|---|---|---|---|---|---|---|
| Quarterly Operating Margin | -102.21% | -430.5% | +8.0% | -176.0% | -347.9% | |
| Annual Operating Margin | -67.38% | – | -50.0% | -3602.2% | -306.8% | |
| Price | $79.48 | +12.6% | +127.5% | +99.5% | +33.2% | |
| PE Ratio | - | – | – | – | – | |
| Quarterly Revenue | $156.72M | -65.3% | +17.1% | -1.9% | -2.1% | |
| Quarterly Operating Profit | -$160.18M | -214.6% | -7.8% | -170.8% | -338.4% | |
| Quarterly Gross Margin | 96.67% | -1.8% | +1.7% | +0.8% | +1.4% | |
| Quarterly Net Margin | -82.06% | -400.3% | +21.8% | -179.0% | -258.8% |
Quarterly Operating Margin Highs
| Period | High | Date | Current |
|---|---|---|---|
| 1Y | 30.93% | -430.5% | |
| 3Y | 30.93% | -430.5% | |
| 5Y | 50.23% | -303.5% | |
| All | 52.80% | -293.6% |
Quarterly Operating Margin Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 1Y | -111.59% | +8.4% | |
| 3Y | -136.84% | N/A | +25.3% |
| 5Y | -136.84% | +25.3% | |
| All | -1,233.33% | +91.7% |
Quarterly Operating Margin History
FAQ
What is the current quarterly operating margin of IONS?
As of today, IONS quarterly operating margin is -102.21%
What is IONS quarterly operating margin most recent change?
IONS quarterly operating margin was down -430.46% on September 1, 2025
What is 1-year change in IONS quarterly operating margin?
IONS quarterly operating margin is up +7.99% year-over-year
How far is IONS quarterly operating margin from its all-time high?
IONS quarterly operating margin is currently -293.58% below its historical high of 52.80% set on December 31, 2019
How does IONS quarterly operating margin rank versus sector peers?
IONS quarterly operating margin is higher than 36.77% of companies in Healthcare sector
When is IONS next earnings release?
The next earnings release for IONS is on
Operating Margin Formula
Operating Profit Margin = Operating Profit
Revenue × 100%
Revenue × 100%
Data Sources & References
- IONS Official Website www.ionis.com
- Most Recent Annual Report (10-K) www.sec.gov/Archives/edgar/data/874015/000087401525000089/0000874015-25-000089-index.htm
- IONS Profile on Yahoo Finance finance.yahoo.com/quote/IONS
- IONS Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/ions