What is the current annual net margin of IONS?

As of today, IONS annual net margin is -40.36%

What is 1-year change in IONS annual net margin?

IONS annual net margin is up +37.30% year-over-year

What is 3-year change in IONS annual net margin?

IONS annual net margin is up +12.11% over the past 3 years

How far is IONS annual net margin from its all-time high?

IONS annual net margin is currently -210.97% below its historical high of 36.37% set on December 31, 2018

How does IONS annual net margin rank versus sector peers?

IONS annual net margin is higher than 50.13% of companies in Healthcare sector

When is IONS next annual earnings release?

As of today, the next annual earnings release for IONS has not been scheduled

What is the current quarterly net margin of IONS?

As of today, IONS quarterly net margin is -42.79%

What is IONS quarterly net margin most recent change?

IONS quarterly net margin was down -13.80% on June 30, 2026

What is 1-year change in IONS quarterly net margin?

IONS quarterly net margin is down -256.57% year-over-year

How far is IONS quarterly net margin from its all-time high?

IONS quarterly net margin is currently -145.66% below its historical high of 93.72% set on September 30, 2007

How does IONS quarterly net margin rank versus sector peers?

IONS quarterly net margin is higher than 44.31% of companies in Healthcare sector

When is IONS next earnings release?

The next earnings release for IONS is on November 4, 2026

IONS Net Margin History & Chart Since 1990

Annual Net Margin

-40.36%24.01%+37.30%

December 31, 2025

Summary

Current Value: As of today, IONS annual net margin is -40.36%, up +37.30% on December 31, 2025
Historical Performance: IONS annual net margin is up +12.11% over the past 3 years, up +38.64% over the past 5 years
All-Time High Comparison: IONS annual net margin is currently -210.97% below its historical high of 36.37% set on December 31, 2018
3-Year Low Comparison: IONS annual net margin is +37.30% above its 3-year low of -64.37% reached on December 31, 2024
Sector Comparison: IONS annual net margin is higher than 50.13% of companies in Healthcare sector

Net Margin Chart

beforeafter

Performance

IONS Performance
Metric	Date	Value	1Y	3Y	5Y	15Y
Annual Net Margin	Dec 31, 25	-40.36%	+37.3%	+12.1%	+38.6%	+28.5%
Quarterly Net Margin	Jun 30, 26	-42.79%	-256.6%	+5.5%	+33.5%	+40.6%
Price	Aug 10, 26	$56.94	+36.7%	+43.0%	+46.6%	+758.8%
PE Ratio	Aug 10, 26	-	–	–	–	–
Annual Revenue	Dec 31, 25	$943.71M	+33.8%	+60.7%	+29.4%	+770.0%
Annual Net Income	Dec 31, 25	-$381.39M	+16.0%	-41.4%	+20.5%	-522.7%
Annual Gross Margin	Dec 31, 25	98.31%	+3.2%	+4.8%	+2.4%	+100.0%
Annual Operating Margin	Dec 31, 25	-40.47%	+39.9%	+42.0%	-71.5%	+6.3%

Net Margin Highs

IONS Annual Net Margin Highs Comparison
Period	High	Date	Current
3Y	-40.36%	Dec 31, 25	at high
5Y	-3.53%	Dec 31, 21	-1043.3%
All	36.37%	Dec 31, 18	-211.0%

Net Margin Lows

IONS Annual Net Margin Lows Comparison
Period	Low	Date	Current
3Y	-64.37%	Dec 31, 24	+37.3%
5Y	-65.78%	N/A	+38.6%
All	-334.33%	Dec 31, 04	+87.9%

Net Margin History

Year	Value	Change
2025	-40.36%	+37.3%
2024	-64.37%	-38.4%
2023	-46.50%	-1.3%
2022	-45.92%	-1,200.8%
2021	-3.53%	+94.6%
2020	-65.78%	-341.6%
2019	27.23%	-25.1%
2018	36.37%	+2,340.9%
2017	1.49%	+106.0%
2016	-24.97%	+19.8%
2015	-31.12%	-71.0%
2014	-18.20%	+55.8%
2013	-41.17%	+35.8%
2012	-64.16%	+25.0%
2011	-85.58%	-51.5%
2010	-56.47%	-96.4%
2009	-28.75%	-271.0%
2008	-7.75%	+84.5%

Year	Value	Change
2007	-49.96%	+82.2%
2006	-280.96%	-55.7%
2005	-180.40%	+46.0%
2004	-334.33%	-75.9%
2003	-190.03%	-110.9%
2002	-90.10%	+35.0%
2001	-138.59%	+3.5%
2000	-143.56%	+17.8%
1999	-174.58%	-59.1%
1998	-109.73%	-14.7%
1997	-95.68%	+18.6%
1996	-117.50%	+35.8%
1995	-182.88%	-1.5%
1994	-180.22%	-0.7%
1993	-178.92%	+20.0%
1992	-223.56%	-60.2%
1991	-139.55%	+38.0%
1990	-225.00%	-

FAQ

What is the current annual net margin of IONS?: As of today, IONS annual net margin is -40.36%
What is 1-year change in IONS annual net margin?: IONS annual net margin is up +37.30% year-over-year
What is 3-year change in IONS annual net margin?: IONS annual net margin is up +12.11% over the past 3 years
How far is IONS annual net margin from its all-time high?: IONS annual net margin is currently -210.97% below its historical high of 36.37% set on December 31, 2018
How does IONS annual net margin rank versus sector peers?: IONS annual net margin is higher than 50.13% of companies in Healthcare sector
When is IONS next annual earnings release?: As of today, the next annual earnings release for IONS has not been scheduled

Net Margin Formula

Net Margin = Net Income

Revenue × 100%

Quarterly Net Margin

-42.79%5.19%-13.80%

June 30, 2026

Summary

Current Value: As of today, IONS quarterly net margin is -42.79%, down -13.80% on June 30, 2026
Historical Performance: IONS quarterly net margin is down -256.57% year-over-year, up +5.48% over the past 3 years
All-Time High Comparison: IONS quarterly net margin is currently -145.66% below its historical high of 93.72% set on September 30, 2007
3-Year Low Comparison: IONS quarterly net margin is +64.19% above its 3-year low of -119.50% reached on March 31, 2024
Sector Comparison: IONS quarterly net margin is higher than 44.31% of companies in Healthcare sector

Performance

IONS Performance
Metric	Date	Value	3M	1Y	3Y	5Y
Quarterly Net Margin	Jun 30, 26	-42.79%	-13.8%	-256.6%	+5.5%	+33.5%
Annual Net Margin	Dec 31, 25	-40.36%	–	+37.3%	+12.1%	+38.6%
Price	Aug 10, 26	$56.94	-24.8%	+36.7%	+43.0%	+46.6%
PE Ratio	Aug 10, 26	-	–	–	–	–
Quarterly Revenue	Jun 30, 26	$267.95M	+8.9%	-40.7%	+42.2%	+113.1%
Quarterly Net Income	Jun 30, 26	-$114.65M	-23.9%	-192.8%	-34.4%	-41.8%
Quarterly Gross Margin	Jun 30, 26	96.13%	+0.4%	-2.4%	+0.5%	+2.6%
Quarterly Operating Margin	Jun 30, 26	-38.18%	+20.0%	-223.4%	+20.2%	+34.2%

Quarterly Net Margin Highs

IONS Quarterly Net Margin Highs Comparison
Period	High	Date	Current
1Y	27.33%	N/A	-256.6%
3Y	27.33%	Jun 30, 25	-256.6%
5Y	51.07%	Dec 31, 21	-183.8%
All	93.72%	Sep 30, 07	-145.7%

Quarterly Net Margin Lows

IONS Quarterly Net Margin Lows Comparison
Period	Low	Date	Current
1Y	-112.81%	Dec 31, 25	+62.1%
3Y	-119.50%	Mar 31, 24	+64.2%
5Y	-119.50%	Mar 31, 24	+64.2%
All	-883.33%	Dec 31, 92	+95.2%

Quarterly Net Margin History

Month	Value	Change
Jun 2026	-42.79%	-13.8%
Mar 2026	-37.60%	+66.7%
Dec 2025	-112.81%	-37.5%
Sep 2025	-82.06%	-400.3%
Jun 2025	27.33%	+124.5%
Mar 2025	-111.64%	-143.6%
Dec 2024	-45.82%	+56.4%
Sep 2024	-104.98%	-256.8%
Jun 2024	-29.42%	+75.4%
Mar 2024	-119.50%	-4,214.1%
Dec 2023	-2.77%	+97.3%
Sep 2023	-102.22%	-125.8%
Jun 2023	-45.27%	+52.5%
Mar 2023	-95.25%	-178.4%
Dec 2022	-34.21%	-16.3%
Sep 2022	-29.41%	+62.6%
Jun 2022	-78.58%	-71.1%
Mar 2022	-45.92%	-189.9%
Dec 2021	51.07%	+182.4%
Sep 2021	-61.96%	+3.7%
Jun 2021	-64.31%	+20.1%
Mar 2021	-80.52%	+34.4%
Dec 2020	-122.76%	-436.8%
Sep 2020	-22.87%	+11.4%
Jun 2020	-25.81%	+31.0%
Mar 2020	-37.40%	-190.8%
Dec 2019	41.19%	+275.1%
Sep 2019	10.98%	+278.5%
Jun 2019	-6.15%	-119.4%
Mar 2019	31.62%	+325.7%
Sep 2018	-14.01%	+70.8%
Jun 2018	-48.05%	-541.5%
Mar 2018	-7.49%	-232.9%
Dec 2017	-2.25%	+64.5%
Sep 2017	-6.33%	-130.2%
Jun 2017	-2.75%	-135.5%
Mar 2017	7.74%	-52.0%
Dec 2016	16.13%	+143.3%
Sep 2016	6.63%	+104.5%
Jun 2016	-147.79%	+13.4%
Mar 2016	-170.63%	-23.2%
Dec 2015	-138.51%	-90.2%
Sep 2015	-72.83%	-346.0%
Jun 2015	29.60%	+210.8%
Mar 2015	-26.71%	-173.0%
Dec 2014	36.59%	+160.4%
Sep 2014	-60.54%	-186.0%
Jun 2014	-21.17%	+80.9%
Mar 2014	-111.08%	-93.3%
Dec 2013	-57.46%	+44.8%
Sep 2013	-104.18%	-291.9%
Jun 2013	-26.58%	-588.6%
Mar 2013	-3.86%	+70.9%
Dec 2012	-13.27%	+95.9%
Sep 2012	-324.45%	>-9,900.0%
Jun 2012	-2.55%	+97.5%
Mar 2012	-103.27%	-67.0%
Dec 2011	-61.83%	+52.4%
Sep 2011	-129.78%	-80.1%
Jun 2011	-72.07%	+23.8%
Mar 2011	-94.55%	-78.6%
Dec 2010	-52.93%	-21.7%
Sep 2010	-43.51%	+59.3%
Jun 2010	-107.02%	-231.6%
Mar 2010	-32.27%	+38.1%
Dec 2009	-52.17%	-141.3%
Sep 2009	-21.62%	-228.6%
Jun 2009	-6.58%	-115.7%
Dec 2008	42.02%	+689.8%
Sep 2008	5.32%	+144.2%
Jun 2008	-12.03%	+51.3%
Mar 2008	-24.69%	+95.4%

Month	Value	Change
Dec 2007	-537.08%	-673.1%
Sep 2007	93.72%	+119.2%
Jun 2007	-488.51%	+39.6%
Mar 2007	-809.22%	-743.0%
Dec 2006	-95.99%	+41.9%
Sep 2006	-165.14%	+54.2%
Jun 2006	-360.69%	-2.3%
Mar 2006	-352.56%	-552.4%
Dec 2005	-54.04%	+73.4%
Sep 2005	-203.43%	-9.6%
Jun 2005	-185.60%	+53.4%
Mar 2005	-398.52%	+21.1%
Dec 2004	-505.40%	-40.5%
Sep 2004	-359.71%	-36.4%
Jun 2004	-263.63%	-23.3%
Mar 2004	-213.82%	+18.3%
Dec 2003	-261.62%	-33.1%
Sep 2003	-196.59%	-27.8%
Jun 2003	-153.82%	+11.6%
Mar 2003	-173.98%	-140.3%
Dec 2002	-72.41%	+16.4%
Sep 2002	-86.58%	+16.8%
Jun 2002	-104.01%	-3.9%
Mar 2002	-100.07%	-39.3%
Dec 2001	-71.86%	-12.6%
Sep 2001	-63.81%	+79.0%
Jun 2001	-303.52%	+38.5%
Mar 2001	-493.14%	-153.4%
Dec 2000	-194.64%	-557.8%
Sep 2000	-29.59%	+85.5%
Jun 2000	-204.75%	+54.7%
Mar 2000	-452.07%	-143.2%
Dec 1999	-185.92%	-59.1%
Sep 1999	-116.85%	+49.0%
Jun 1999	-229.23%	-19.6%
Mar 1999	-191.67%	+49.9%
Dec 1998	-382.74%	-8,256.8%
Sep 1998	-4.58%	+97.7%
Jun 1998	-196.47%	-17.5%
Mar 1998	-167.16%	-47.2%
Dec 1997	-113.54%	-550.3%
Sep 1997	-17.46%	+89.2%
Jun 1997	-162.07%	+13.3%
Mar 1997	-186.96%	-50.0%
Dec 1996	-124.62%	-5.9%
Sep 1996	-117.65%	+24.3%
Jun 1996	-155.32%	-94.9%
Mar 1996	-79.69%	+46.9%
Dec 1995	-150.00%	+19.6%
Sep 1995	-186.49%	-4.3%
Jun 1995	-178.79%	+21.2%
Mar 1995	-226.92%	-34.5%
Sep 1994	-168.75%	-2.6%
Jun 1994	-164.52%	-151.6%
Mar 1994	-65.38%	+58.8%
Dec 1993	-158.62%	-13.8%
Sep 1993	-139.39%	+7.1%
Jun 1993	-150.00%	+20.6%
Mar 1993	-188.89%	+78.6%
Dec 1992	-883.33%	-494.9%
Sep 1992	-148.48%	+20.6%
Jun 1992	-186.96%	+6.5%
Mar 1992	-200.00%	+50.0%
Dec 1991	-400.00%	-233.3%
Sep 1991	-120.00%	+10.0%
Jun 1991	-133.33%	-81.8%
Mar 1991	-73.33%	+66.7%
Dec 1990	-220.00%	0.0%
Sep 1990	-220.00%	0.0%
Jun 1990	-220.00%	0.0%
Mar 1990	-220.00%	-

FAQ

What is the current quarterly net margin of IONS?: As of today, IONS quarterly net margin is -42.79%
What is IONS quarterly net margin most recent change?: IONS quarterly net margin was down -13.80% on June 30, 2026
What is 1-year change in IONS quarterly net margin?: IONS quarterly net margin is down -256.57% year-over-year
How far is IONS quarterly net margin from its all-time high?: IONS quarterly net margin is currently -145.66% below its historical high of 93.72% set on September 30, 2007
How does IONS quarterly net margin rank versus sector peers?: IONS quarterly net margin is higher than 44.31% of companies in Healthcare sector
When is IONS next earnings release?: The next earnings release for IONS is on November 4, 2026

Net Margin Formula

Net Margin = Net Income

Revenue × 100%

Data Sources & References

IONS Official Website www.ionis.com
Most Recent Annual Report (10-K) www.sec.gov/Archives/edgar/data/874015/000087401526000115/0000874015-26-000115-index.htm
IONS Profile on Yahoo Finance finance.yahoo.com/quote/IONS
IONS Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/ions