Annual Operating Profit:
-$475.11M-$121.40M(-34.32%)Summary
- As of today, IONS annual operating income is -$475.11 million, with the most recent change of -$121.40 million (-34.32%) on December 31, 2024.
- During the last 3 years, IONS annual operating profit has fallen by -$460.37 million (-3123.47%).
- IONS annual operating profit is now -229.85% below its all-time high of $365.88 million, reached on December 31, 2019.
Performance
IONS Operating Profit Chart
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Quarterly Operating Profit:
$139.84M+$286.79M(+195.16%)Summary
- As of today, IONS quarterly operating income is $139.84 million, with the most recent change of +$286.79 million (+195.16%) on June 30, 2025.
- Over the past year, IONS quarterly operating profit has increased by +$205.92 million (+311.63%).
- IONS quarterly operating profit is now -46.35% below its all-time high of $260.65 million, reached on December 31, 2019.
Performance
IONS Quarterly Operating Profit Chart
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TTM Operating Profit:
-$266.57M+$205.92M(+43.58%)Summary
- As of today, IONS TTM operating income is -$266.57 million, with the most recent change of +$205.92 million (+43.58%) on June 30, 2025.
- Over the past year, IONS TTM operating profit has increased by +$98.45 million (+26.97%).
- IONS TTM operating profit is now -172.86% below its all-time high of $365.88 million, reached on December 31, 2019.
Performance
IONS TTM Operating Profit Chart
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Operating Profit Formula
Operating Profit = Gross Profit − Operating Expenses
IONS Operating Profit Trends
| PeriodPeriod | AnnualAnnual | QuarterlyQuarterly | TTMTTM |
|---|---|---|---|
| 1Y1 Year | -34.3% | +311.6% | +27.0% |
| 3Y3 Years | -3123.5% | +263.5% | -3124.5% |
| 5Y5 Years | -229.8% | +370.2% | -339.6% |
IONS Operating Profit Highs & Lows
| PeriodPeriod | Annual vs HighAnnual vs High | Annual vs LowAnnual vs Low | Quarter. vs HighQuarter. vs High | Quarter. vs LowQuarter. vs Low | TTM vs HighTTM vs High | TTM vs LowTTM vs Low | |
|---|---|---|---|---|---|---|---|
| 3Y | 3-Year | -3123.5% | at low | at high | +167.2% | -1627.5% | +52.0% |
| 5Y | 5-Year | -229.8% | at low | -36.3% | +167.2% | -339.6% | +52.0% |
| All-Time | All-Time | -229.8% | at low | -46.4% | +167.2% | -172.9% | +52.0% |
IONS Operating Profit History
| Date | Annual | Quarterly | TTM |
|---|---|---|---|
| Jun 2025 | - | $139.84M(+195.2%) | -$266.57M(+43.6%) |
| Mar 2025 | - | -$146.95M(-32.6%) | -$472.49M(+0.5%) |
| Dec 2024 | -$475.11M(-34.3%) | -$110.84M(+25.4%) | -$475.06M(-28.3%) |
| Sep 2024 | - | -$148.62M(-124.9%) | -$370.33M(-1.5%) |
| Jun 2024 | - | -$66.08M(+55.8%) | -$365.02M(+6.2%) |
| Mar 2024 | - | -$149.52M(-2346.3%) | -$389.14M(-10.0%) |
| Dec 2023 | -$353.71M(+13.8%) | -$6.11M(+95.7%) | -$353.77M(+36.3%) |
| Sep 2023 | - | -$143.31M(-58.9%) | -$555.62M(-17.9%) |
| Jun 2023 | - | -$90.19M(+21.0%) | -$471.44M(-1.0%) |
| Mar 2023 | - | -$114.15M(+45.1%) | -$466.76M(-13.8%) |
| Dec 2022 | -$410.19M(-2683.0%) | -$207.96M(-251.7%) | -$410.12M(-2450.1%) |
| Sep 2022 | - | -$59.14M(+30.8%) | $17.45M(+311.1%) |
| Jun 2022 | - | -$85.51M(-48.7%) | -$8.27M(-152.9%) |
| Mar 2022 | - | -$57.50M(-126.2%) | $15.63M(+206.1%) |
| Dec 2021 | -$14.74M(+90.2%) | $219.60M(+358.8%) | -$14.74M(+93.7%) |
| Sep 2021 | - | -$84.86M(-37.7%) | -$234.84M(-25.9%) |
| Jun 2021 | - | -$61.61M(+29.9%) | -$186.47M(-5.6%) |
| Mar 2021 | - | -$87.87M(>-9900.0%) | -$176.62M(-17.8%) |
| Dec 2020 | -$149.96M(-141.0%) | -$499.00K(+98.6%) | -$149.88M(-234.7%) |
| Sep 2020 | - | -$36.49M(+29.5%) | $111.28M(-26.0%) |
| Jun 2020 | - | -$51.75M(+15.3%) | $150.29M(-18.0%) |
| Mar 2020 | - | -$61.13M(-123.5%) | $183.22M(-49.9%) |
| Dec 2019 | $365.88M(+696.2%) | $260.65M(>+9900.0%) | $365.88M(+215.4%) |
| Sep 2019 | - | $2.52M(+113.4%) | $116.02M(+22.2%) |
| Jun 2019 | - | -$18.83M(-115.5%) | $94.92M(+49.6%) |
| Mar 2019 | - | $121.53M(+1026.9%) | $63.47M(+203.4%) |
| Dec 2018 | -$61.37M(-297.7%) | $10.79M(+158.1%) | -$61.37M(+21.7%) |
| Sep 2018 | - | -$18.57M(+63.1%) | -$78.35M(-61.7%) |
| Jun 2018 | - | -$50.28M(-1423.2%) | -$48.47M(-686.7%) |
| Mar 2018 | - | -$3.30M(+46.8%) | $8.26M(-73.4%) |
| Dec 2017 | $31.05M(+254.0%) | -$6.20M(-154.8%) | $31.05M(-70.3%) |
| Sep 2017 | - | $11.31M(+75.4%) | $104.56M(-4.4%) |
| Jun 2017 | - | $6.45M(-66.9%) | $109.35M(+102.6%) |
| Mar 2017 | - | $19.48M(-71.1%) | $53.98M(+367.7%) |
| Dec 2016 | -$20.16M(+73.4%) | $67.31M(+317.9%) | -$20.16M(+86.6%) |
| Sep 2016 | - | $16.11M(+132.9%) | -$150.41M(+29.9%) |
| Jun 2016 | - | -$48.93M(+10.5%) | -$214.66M(-77.3%) |
| Mar 2016 | - | -$54.65M(+13.2%) | -$121.08M(-59.8%) |
| Dec 2015 | -$75.76M(-58.7%) | -$62.94M(-30.8%) | -$75.76M(-2664.1%) |
| Sep 2015 | - | -$48.14M(-207.8%) | -$2.74M(-111.5%) |
| Jun 2015 | - | $44.65M(+578.5%) | $23.90M(+187.3%) |
| Mar 2015 | - | -$9.33M(-192.6%) | -$27.39M(+42.6%) |
| Dec 2014 | -$47.73M(+7.6%) | $10.08M(+146.9%) | -$47.73M(+38.5%) |
| Sep 2014 | - | -$21.49M(-223.2%) | -$77.67M(+4.9%) |
| Jun 2014 | - | -$6.65M(+77.6%) | -$81.68M(+1.5%) |
| Mar 2014 | - | -$29.67M(-49.4%) | -$82.96M(-60.6%) |
| Dec 2013 | -$51.67M(+25.0%) | -$19.86M(+22.1%) | -$51.67M(+10.8%) |
| Sep 2013 | - | -$25.50M(-221.7%) | -$57.93M(+4.2%) |
| Jun 2013 | - | -$7.93M(-587.9%) | -$60.47M(-23.8%) |
| Mar 2013 | - | $1.63M(+106.2%) | -$48.84M(+29.1%) |
| Dec 2012 | -$68.92M(+3.1%) | -$26.12M(+6.9%) | -$68.92M(-12.2%) |
| Sep 2012 | - | -$28.05M(-858.8%) | -$61.42M(-10.3%) |
| Jun 2012 | - | $3.70M(+120.0%) | -$55.69M(+24.2%) |
| Mar 2012 | - | -$18.45M(+0.9%) | -$73.45M(-3.3%) |
| Dec 2011 | -$71.10M(-47.0%) | -$18.62M(+16.6%) | -$71.10M(-4.0%) |
| Sep 2011 | - | -$22.32M(-58.7%) | -$68.34M(-24.3%) |
| Jun 2011 | - | -$14.06M(+12.7%) | -$54.97M(+7.7%) |
| Mar 2011 | - | -$16.11M(-1.6%) | -$59.59M(-23.2%) |
| Dec 2010 | -$48.36M(-75.6%) | -$15.86M(-77.2%) | -$48.36M(-9.5%) |
| Sep 2010 | - | -$8.95M(+52.1%) | -$44.17M(+3.2%) |
| Jun 2010 | - | -$18.67M(-282.6%) | -$45.62M(-43.6%) |
| Mar 2010 | - | -$4.88M(+58.2%) | -$31.78M(-15.4%) |
| Dec 2009 | -$27.54M(-110.9%) | -$11.67M(-12.3%) | -$27.54M(-15.0%) |
| Sep 2009 | - | -$10.40M(-115.4%) | -$23.94M(-79.1%) |
| Jun 2009 | - | -$4.83M(-651.9%) | -$13.37M(-79.2%) |
| Mar 2009 | - | -$642.00K(+92.1%) | -$7.46M(+42.9%) |
| Dec 2008 | -$13.06M(+60.3%) | -$8.08M(-4688.6%) | -$13.06M(-76.5%) |
| Sep 2008 | - | $176.00K(-83.7%) | -$7.40M(-397.9%) |
| Jun 2008 | - | $1.08M(+117.3%) | $2.48M(+113.6%) |
| Mar 2008 | - | -$6.24M(-158.5%) | -$18.26M(+44.5%) |
| Dec 2007 | -$32.92M | -$2.41M(-124.0%) | -$32.92M(+25.9%) |
| Date | Annual | Quarterly | TTM |
|---|---|---|---|
| Sep 2007 | - | $10.06M(+151.2%) | -$44.42M(+39.2%) |
| Jun 2007 | - | -$19.66M(+5.9%) | -$73.02M(-3.3%) |
| Mar 2007 | - | -$20.90M(-50.2%) | -$70.68M(-7.5%) |
| Dec 2006 | -$65.75M(-30.9%) | -$13.91M(+25.0%) | -$65.75M(-8.0%) |
| Sep 2006 | - | -$18.54M(-7.1%) | -$60.87M(-11.0%) |
| Jun 2006 | - | -$17.32M(-8.4%) | -$54.82M(-10.1%) |
| Mar 2006 | - | -$15.98M(-76.9%) | -$49.78M(+0.9%) |
| Dec 2005 | -$50.22M(+41.2%) | -$9.03M(+27.7%) | -$50.22M(+17.1%) |
| Sep 2005 | - | -$12.49M(-1.8%) | -$60.56M(+14.0%) |
| Jun 2005 | - | -$12.27M(+25.3%) | -$70.45M(+11.4%) |
| Mar 2005 | - | -$16.42M(+15.2%) | -$79.51M(+6.9%) |
| Dec 2004 | -$85.43M(-10.7%) | -$19.37M(+13.4%) | -$85.43M(+2.4%) |
| Sep 2004 | - | -$22.38M(-4.9%) | -$87.53M(-3.9%) |
| Jun 2004 | - | -$21.34M(+4.5%) | -$84.22M(-4.5%) |
| Mar 2004 | - | -$22.34M(-4.0%) | -$80.60M(-4.4%) |
| Dec 2003 | -$77.17M(-56.1%) | -$21.48M(-12.7%) | -$77.18M(-17.7%) |
| Sep 2003 | - | -$19.07M(-7.6%) | -$65.57M(-2.4%) |
| Jun 2003 | - | -$17.72M(+6.3%) | -$64.01M(-9.2%) |
| Mar 2003 | - | -$18.91M(-91.6%) | -$58.63M(-18.6%) |
| Dec 2002 | -$49.44M(-7.2%) | -$9.87M(+43.6%) | -$49.44M(-4.6%) |
| Sep 2002 | - | -$17.51M(-41.9%) | -$47.26M(-37.1%) |
| Jun 2002 | - | -$12.34M(-27.0%) | -$34.46M(+10.7%) |
| Mar 2002 | - | -$9.72M(-26.3%) | -$38.59M(+16.3%) |
| Dec 2001 | -$46.10M(-59.0%) | -$7.70M(-63.5%) | -$46.10M(+4.8%) |
| Sep 2001 | - | -$4.71M(+71.4%) | -$48.42M(-11.3%) |
| Jun 2001 | - | -$16.46M(+4.5%) | -$43.50M(-23.5%) |
| Mar 2001 | - | -$17.23M(-72.1%) | -$35.22M(-21.5%) |
| Dec 2000 | -$28.99M(+32.7%) | -$10.01M(-4960.2%) | -$28.99M(+7.9%) |
| Sep 2000 | - | $206.00K(+102.5%) | -$31.48M(+20.9%) |
| Jun 2000 | - | -$8.18M(+25.7%) | -$39.78M(+8.8%) |
| Mar 2000 | - | -$11.01M(+11.9%) | -$43.61M(-1.2%) |
| Dec 1999 | -$43.10M(-32.6%) | -$12.50M(-54.3%) | -$43.10M(-6.9%) |
| Sep 1999 | - | -$8.10M(+32.5%) | -$40.30M(-29.6%) |
| Jun 1999 | - | -$12.00M(-14.3%) | -$31.10M(+3.1%) |
| Mar 1999 | - | -$10.50M(-8.2%) | -$32.10M(+1.5%) |
| Dec 1998 | -$32.50M(-3.8%) | -$9.70M(-981.8%) | -$32.60M(+1.8%) |
| Sep 1998 | - | $1.10M(+108.5%) | -$33.20M(+10.0%) |
| Jun 1998 | - | -$13.00M(-18.2%) | -$36.90M(-9.8%) |
| Mar 1998 | - | -$11.00M(-6.8%) | -$33.60M(-6.7%) |
| Dec 1997 | -$31.30M(-7.6%) | -$10.30M(-296.2%) | -$31.50M(-2.6%) |
| Sep 1997 | - | -$2.60M(+73.2%) | -$30.70M(+11.8%) |
| Jun 1997 | - | -$9.70M(-9.0%) | -$34.80M(-4.8%) |
| Mar 1997 | - | -$8.90M(+6.3%) | -$33.20M(-14.1%) |
| Dec 1996 | -$29.10M(-13.7%) | -$9.50M(-41.8%) | -$29.10M(-12.8%) |
| Sep 1996 | - | -$6.70M(+17.3%) | -$25.80M(+2.6%) |
| Jun 1996 | - | -$8.10M(-68.8%) | -$26.50M(-8.6%) |
| Mar 1996 | - | -$4.80M(+22.6%) | -$24.40M(+5.1%) |
| Dec 1995 | -$25.60M(-13.8%) | -$6.20M(+16.2%) | -$25.70M(+16.3%) |
| Sep 1995 | - | -$7.40M(-23.3%) | -$30.70M(-8.5%) |
| Jun 1995 | - | -$6.00M(+1.6%) | -$28.30M(-4.4%) |
| Mar 1995 | - | -$6.10M(+45.5%) | -$27.10M(-6.3%) |
| Dec 1994 | -$22.50M(-23.0%) | -$11.20M(-124.0%) | -$25.50M(-36.4%) |
| Sep 1994 | - | -$5.00M(-4.2%) | -$18.70M(-3.3%) |
| Jun 1994 | - | -$4.80M(-6.7%) | -$18.10M(-1.1%) |
| Mar 1994 | - | -$4.50M(-2.3%) | -$17.90M(+3.2%) |
| Dec 1993 | -$18.30M(+15.3%) | -$4.40M(0.0%) | -$18.50M(+14.0%) |
| Sep 1993 | - | -$4.40M(+4.3%) | -$21.50M(+2.3%) |
| Jun 1993 | - | -$4.60M(+9.8%) | -$22.00M(-1.9%) |
| Mar 1993 | - | -$5.10M(+31.1%) | -$21.60M(-0.5%) |
| Dec 1992 | -$21.60M(-105.7%) | -$7.40M(-51.0%) | -$21.50M(-12.6%) |
| Sep 1992 | - | -$4.90M(-16.7%) | -$19.10M(-15.1%) |
| Jun 1992 | - | -$4.20M(+16.0%) | -$16.60M(-12.9%) |
| Mar 1992 | - | -$5.00M(0.0%) | -$14.70M(-33.6%) |
| Dec 1991 | -$10.50M(-133.3%) | -$5.00M(-108.3%) | -$11.00M(+8.3%) |
| Sep 1991 | - | -$2.40M(-4.3%) | -$12.00M(-31.9%) |
| Jun 1991 | - | -$2.30M(-76.9%) | -$9.10M(-44.4%) |
| Mar 1991 | - | -$1.30M(+78.3%) | -$6.30M(-40.0%) |
| Dec 1990 | -$4.50M | -$6.00M(-1300.0%) | -$4.50M(-400.0%) |
| Sep 1990 | - | $500.00K(0.0%) | $1.50M(+50.0%) |
| Jun 1990 | - | $500.00K(0.0%) | $1.00M(+100.0%) |
| Mar 1990 | - | $500.00K | $500.00K |
FAQ
- What is Ionis Pharmaceuticals, Inc. annual operating income?
- What is the all-time high annual operating profit for Ionis Pharmaceuticals, Inc.?
- What is Ionis Pharmaceuticals, Inc. annual operating profit year-on-year change?
- What is Ionis Pharmaceuticals, Inc. quarterly operating income?
- What is the all-time high quarterly operating profit for Ionis Pharmaceuticals, Inc.?
- What is Ionis Pharmaceuticals, Inc. quarterly operating profit year-on-year change?
- What is Ionis Pharmaceuticals, Inc. TTM operating income?
- What is the all-time high TTM operating profit for Ionis Pharmaceuticals, Inc.?
- What is Ionis Pharmaceuticals, Inc. TTM operating profit year-on-year change?
What is Ionis Pharmaceuticals, Inc. annual operating income?
The current annual operating profit of IONS is -$475.11M
What is the all-time high annual operating profit for Ionis Pharmaceuticals, Inc.?
Ionis Pharmaceuticals, Inc. all-time high annual operating income is $365.88M
What is Ionis Pharmaceuticals, Inc. annual operating profit year-on-year change?
Over the past year, IONS annual operating income has changed by -$121.40M (-34.32%)
What is Ionis Pharmaceuticals, Inc. quarterly operating income?
The current quarterly operating profit of IONS is $139.84M
What is the all-time high quarterly operating profit for Ionis Pharmaceuticals, Inc.?
Ionis Pharmaceuticals, Inc. all-time high quarterly operating income is $260.65M
What is Ionis Pharmaceuticals, Inc. quarterly operating profit year-on-year change?
Over the past year, IONS quarterly operating income has changed by +$205.92M (+311.63%)
What is Ionis Pharmaceuticals, Inc. TTM operating income?
The current TTM operating profit of IONS is -$266.57M
What is the all-time high TTM operating profit for Ionis Pharmaceuticals, Inc.?
Ionis Pharmaceuticals, Inc. all-time high TTM operating income is $365.88M
What is Ionis Pharmaceuticals, Inc. TTM operating profit year-on-year change?
Over the past year, IONS TTM operating income has changed by +$98.45M (+26.97%)