Annual Operating Profit
-$382.00M$93.08M+19.59%
Summary
- Current Value
- As of today, IONS annual operating profit is -$382.00M, up +19.59% on
- Historical Performance
- IONS annual operating profit is up +6.87% over the past 3 years, down -121.99% over the past 5 years
- All-Time High Comparison
- IONS annual operating profit is currently -204.40% below its historical high of $365.88M set on
- 3-Year Low Comparison
- IONS annual operating profit is +19.59% above its 3-year low of -$475.08M reached on
- Sector Comparison
- IONS annual operating profit is higher than 3.31% of companies in Healthcare sector
Operating Profit Chart
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Series
SUGGESTED SERIES
Performance
| Metric | Date | Value | 1Y | 3Y | 5Y | 15Y |
|---|---|---|---|---|---|---|
| Annual Operating Profit | -$382.00M | +19.6% | +6.9% | -122.0% | -715.3% | |
| Quarterly Operating Profit | -$215.00M | -95.5% | -3.4% | -834.8% | -1255.9% | |
| TTM Operating Profit | -$382.23M | +19.4% | +6.8% | -121.7% | -707.1% | |
| Price | $81.15 | +158.8% | +124.1% | +54.9% | +793.7% | |
| PE Ratio | - | – | – | – | – | |
| Annual Revenue | $944.00M | +33.9% | +60.7% | +29.4% | +770.3% | |
| Annual EPS | -$2.38 | +21.6% | -25.2% | +25.2% | -284.1% | |
| Annual Gross Profit | $928.00M | +38.1% | +68.4% | +32.5% | +100.0% | |
| $1.31B | +14.2% | +36.3% | +50.2% | +2695.8% |
Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 3Y | -$353.73M | -8.0% | |
| 5Y | -$30.19M | -1165.5% | |
| All | $365.88M | -204.4% |
Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 3Y | -$475.08M | +19.6% | |
| 5Y | -$475.08M | +19.6% | |
| All | -$475.08M | +19.6% |
Operating Profit History
FAQ
What is the current annual operating profit of IONS?
As of today, IONS annual operating profit is -$382.00M
What is 1-year change in IONS annual operating profit?
IONS annual operating profit is up +19.59% year-over-year
What is 3-year change in IONS annual operating profit?
IONS annual operating profit is up +6.87% over the past 3 years
How far is IONS annual operating profit from its all-time high?
IONS annual operating profit is currently -204.40% below its historical high of $365.88M set on December 31, 2019
How does IONS annual operating profit rank versus sector peers?
IONS annual operating profit is higher than 3.31% of companies in Healthcare sector
When is IONS next annual earnings release?
As of today, the next annual earnings release for IONS has not been scheduled
Quarterly Operating Profit
-$215.00M$54.82M-34.22%
Summary
- Current Value
- As of today, IONS quarterly operating profit is -$215.00M, down -34.22% on
- Historical Performance
- IONS quarterly operating profit is down -95.45% year-over-year, down -3.37% over the past 3 years
- All-Time High Comparison
- IONS quarterly operating profit is currently -182.48% below its historical high of $260.65M set on
- 3-Year Low Comparison
- IONS quarterly operating profit is at its 3-year low
- Sector Comparison
- IONS quarterly operating profit is higher than 1.17% of companies in Healthcare sector
Performance
| Metric | Date | Value | 3M | 1Y | 3Y | 5Y |
|---|---|---|---|---|---|---|
| Quarterly Operating Profit | -$215.00M | -34.2% | -95.5% | -3.4% | -834.8% | |
| Annual Operating Profit | -$382.00M | – | +19.6% | +6.9% | -122.0% | |
| TTM Operating Profit | -$382.23M | -37.9% | +19.4% | +6.8% | -121.7% | |
| Price | $81.15 | -1.9% | +158.8% | +124.1% | +54.9% | |
| PE Ratio | - | – | – | – | – | |
| Quarterly Revenue | $203.00M | +29.5% | -10.6% | +33.5% | -30.0% | |
| Quarterly EPS | -$1.41 | -75.6% | -114.8% | -286.0% | +44.3% | |
| Quarterly Gross Profit | $195.00M | +28.7% | -10.4% | +38.3% | -31.0% | |
| $410.00M | +31.5% | +25.1% | +17.5% | +34.2% |
Quarterly Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 1Y | $139.82M | -253.8% | |
| 3Y | $139.82M | -253.8% | |
| 5Y | $221.00M | -197.3% | |
| All | $260.65M | -182.5% |
Quarterly Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 1Y | -$215.00M | at low | |
| 3Y | -$215.00M | at low | |
| 5Y | -$215.00M | at low | |
| All | -$215.00M | at low |
Quarterly Operating Profit History
FAQ
What is the current quarterly operating profit of IONS?
As of today, IONS quarterly operating profit is -$215.00M
What is IONS quarterly operating profit most recent change?
IONS quarterly operating profit was down -34.22% on December 31, 2025
What is 1-year change in IONS quarterly operating profit?
IONS quarterly operating profit is down -95.45% year-over-year
How far is IONS quarterly operating profit from its all-time high?
IONS quarterly operating profit is currently -182.48% below its historical high of $260.65M set on December 31, 2019
How does IONS quarterly operating profit rank versus sector peers?
IONS quarterly operating profit is higher than 1.17% of companies in Healthcare sector
When is IONS next earnings release?
The next earnings release for IONS is on
TTM Operating Profit
-$382.23M$105.00M-37.88%
Summary
- Current Value
- As of today, IONS TTM operating profit is -$382.23M, down -37.88% on
- Historical Performance
- IONS TTM operating profit is up +19.41% year-over-year, up +6.81% over the past 3 years
- All-Time High Comparison
- IONS TTM operating profit is currently -204.47% below its historical high of $365.89M set on
- 3-Year Low Comparison
- IONS TTM operating profit is +31.21% above its 3-year low of -$555.61M reached on
- Sector Comparison
- IONS TTM operating profit is higher than 3.32% of companies in Healthcare sector
Performance
| Metric | Date | Value | 3M | 1Y | 3Y | 5Y |
|---|---|---|---|---|---|---|
| TTM Operating Profit | -$382.23M | -37.9% | +19.4% | +6.8% | -121.7% | |
| Annual Operating Profit | -$382.00M | – | +19.6% | +6.9% | -122.0% | |
| Quarterly Operating Profit | -$215.00M | -34.2% | -95.5% | -3.4% | -834.8% | |
| Price | $81.15 | -1.9% | +158.8% | +124.1% | +54.9% | |
| PE Ratio | - | – | – | – | – | |
| TTM Revenue | $943.38M | -2.5% | +33.7% | +60.6% | +29.4% | |
| TTM EPS | -$2.47 | -44.1% | +18.8% | -29.9% | +22.4% | |
| TTM Gross Profit | $916.29M | -2.4% | +36.3% | +66.3% | +30.9% | |
| $410.00M | +31.5% | +25.1% | +17.5% | +34.2% |
TTM Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 1Y | -$265.70M | -43.9% | |
| 3Y | -$265.70M | -43.9% | |
| 5Y | $18.83M | -2130.1% | |
| All | $365.89M | -204.5% |
TTM Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 1Y | -$474.26M | N/A | +19.4% |
| 3Y | -$555.61M | +31.2% | |
| 5Y | -$555.61M | +31.2% | |
| All | -$555.61M | +31.2% |
TTM Operating Profit History
FAQ
What is the current TTM operating profit of IONS?
As of today, IONS TTM operating profit is -$382.23M
What is IONS TTM operating profit most recent change?
IONS TTM operating profit was down -37.88% on December 31, 2025
What is 1-year change in IONS TTM operating profit?
IONS TTM operating profit is up +19.41% year-over-year
How far is IONS TTM operating profit from its all-time high?
IONS TTM operating profit is currently -204.47% below its historical high of $365.89M set on December 31, 2019
How does IONS TTM operating profit rank versus sector peers?
IONS TTM operating profit is higher than 3.32% of companies in Healthcare sector
When is IONS next earnings release?
The next earnings release for IONS is on
Operating Profit Formula
Operating Profit = Gross Profit −
Data Sources & References
- IONS Official Website www.ionis.com
- Most Recent Quarterly Report (10-Q) www.sec.gov/Archives/edgar/data/874015/000087401526000115/0000874015-26-000115-index.htm
- Most Recent Annual Report (10-K) www.sec.gov/Archives/edgar/data/874015/000087401526000115/0000874015-26-000115-index.htm
- IONS Profile on Yahoo Finance finance.yahoo.com/quote/IONS
- IONS Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/ions