Annual Operating Profit
-$382.00M$93.08M+19.59%
Summary
- Current Value
- As of today, IONS annual operating profit is -$382.00M, up +19.59% on
- Historical Performance
- IONS annual operating profit is up +6.87% over the past 3 years, down -121.99% over the past 5 years
- All-Time High Comparison
- IONS annual operating profit is currently -204.40% below its historical high of $365.88M set on
- 3-Year Low Comparison
- IONS annual operating profit is +19.59% above its 3-year low of -$475.08M reached on
- Sector Comparison
- IONS annual operating profit is higher than 3.35% of companies in Healthcare sector
Operating Profit Chart
SUGGESTED SERIES
Performance
| Metric | Date | Value | 1Y | 3Y | 5Y | 15Y |
|---|---|---|---|---|---|---|
| Annual Operating Profit | -$382.00M | +19.6% | +6.9% | -122.0% | -715.3% | |
| Quarterly Operating Profit | -$117.42M | +20.0% | -2.9% | -27.7% | -685.8% | |
| TTM Operating Profit | -$352.79M | +25.2% | +24.4% | -73.6% | -513.7% | |
| Price | $74.23 | +125.0% | +104.8% | +94.1% | +723.0% | |
| PE Ratio | - | – | – | – | – | |
| Annual Revenue | $943.71M | +33.8% | +60.7% | +29.4% | +770.0% | |
| Annual EPS | -$2.38 | +21.5% | -25.4% | +25.1% | -284.4% | |
| Annual Gross Profit | $928.00M | +38.1% | +68.4% | +32.5% | +100.0% | |
| $1.31B | +14.2% | +36.3% | +50.2% | +2695.8% |
Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 3Y | -$353.73M | -8.0% | |
| 5Y | -$30.19M | -1165.5% | |
| All | $365.88M | -204.4% |
Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 3Y | -$475.08M | +19.6% | |
| 5Y | -$475.08M | +19.6% | |
| All | -$475.08M | +19.6% |
Operating Profit History
FAQ
What is the current annual operating profit of IONS?
As of today, IONS annual operating profit is -$382.00M
What is 1-year change in IONS annual operating profit?
IONS annual operating profit is up +19.59% year-over-year
What is 3-year change in IONS annual operating profit?
IONS annual operating profit is up +6.87% over the past 3 years
How far is IONS annual operating profit from its all-time high?
IONS annual operating profit is currently -204.40% below its historical high of $365.88M set on December 31, 2019
How does IONS annual operating profit rank versus sector peers?
IONS annual operating profit is higher than 3.35% of companies in Healthcare sector
When is IONS next annual earnings release?
As of today, the next annual earnings release for IONS has not been scheduled
Quarterly Operating Profit
-$117.42M$97.58M+45.38%
Summary
- Current Value
- As of today, IONS quarterly operating profit is -$117.42M, up +45.38% on
- Historical Performance
- IONS quarterly operating profit is up +20.04% year-over-year, down -2.87% over the past 3 years
- All-Time High Comparison
- IONS quarterly operating profit is currently -145.05% below its historical high of $260.65M set on
- 3-Year Low Comparison
- IONS quarterly operating profit is +45.38% above its 3-year low of -$215.00M reached on
- Sector Comparison
- IONS quarterly operating profit is higher than 2.56% of companies in Healthcare sector
Performance
| Metric | Date | Value | 3M | 1Y | 3Y | 5Y |
|---|---|---|---|---|---|---|
| Quarterly Operating Profit | -$117.42M | +45.4% | +20.0% | -2.9% | -27.7% | |
| Annual Operating Profit | -$382.00M | – | +19.6% | +6.9% | -122.0% | |
| TTM Operating Profit | -$352.79M | +7.7% | +25.2% | +24.4% | -73.6% | |
| Price | $74.23 | -7.9% | +125.0% | +104.8% | +94.1% | |
| PE Ratio | - | – | – | – | – | |
| Quarterly Revenue | $246.09M | +21.2% | +87.0% | +88.5% | +120.5% | |
| Quarterly EPS | -$0.56 | +60.3% | +39.4% | +35.6% | +12.1% | |
| Quarterly Gross Profit | $235.66M | +23.3% | +88.9% | +90.7% | +126.2% | |
| $353.09M | -13.1% | +30.0% | +48.5% | +80.0% |
Quarterly Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 1Y | $139.82M | -184.0% | |
| 3Y | $139.82M | -184.0% | |
| 5Y | $221.00M | -153.1% | |
| All | $260.65M | -145.1% |
Quarterly Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 1Y | -$215.00M | +45.4% | |
| 3Y | -$215.00M | +45.4% | |
| 5Y | -$215.00M | +45.4% | |
| All | -$215.00M | +45.4% |
Quarterly Operating Profit History
FAQ
What is the current quarterly operating profit of IONS?
As of today, IONS quarterly operating profit is -$117.42M
What is IONS quarterly operating profit most recent change?
IONS quarterly operating profit was up +45.38% on March 31, 2026
What is 1-year change in IONS quarterly operating profit?
IONS quarterly operating profit is up +20.04% year-over-year
How far is IONS quarterly operating profit from its all-time high?
IONS quarterly operating profit is currently -145.05% below its historical high of $260.65M set on December 31, 2019
How does IONS quarterly operating profit rank versus sector peers?
IONS quarterly operating profit is higher than 2.56% of companies in Healthcare sector
When is IONS next earnings release?
The next earnings release for IONS is on
TTM Operating Profit
-$352.79M$29.44M+7.70%
Summary
- Current Value
- As of today, IONS TTM operating profit is -$352.79M, up +7.70% on
- Historical Performance
- IONS TTM operating profit is up +25.19% year-over-year, up +24.43% over the past 3 years
- All-Time High Comparison
- IONS TTM operating profit is currently -196.42% below its historical high of $365.89M set on
- 3-Year Low Comparison
- IONS TTM operating profit is +36.50% above its 3-year low of -$555.61M reached on
- Sector Comparison
- IONS TTM operating profit is higher than 3.85% of companies in Healthcare sector
Performance
| Metric | Date | Value | 3M | 1Y | 3Y | 5Y |
|---|---|---|---|---|---|---|
| TTM Operating Profit | -$352.79M | +7.7% | +25.2% | +24.4% | -73.6% | |
| Annual Operating Profit | -$382.00M | – | +19.6% | +6.9% | -122.0% | |
| Quarterly Operating Profit | -$117.42M | +45.4% | +20.0% | -2.9% | -27.7% | |
| Price | $74.23 | -7.9% | +125.0% | +104.8% | +94.1% | |
| PE Ratio | - | – | – | – | – | |
| TTM Revenue | $1.06B | +12.1% | +47.4% | +83.6% | +49.6% | |
| TTM EPS | -$2.10 | +14.8% | +29.5% | +9.0% | +40.5% | |
| TTM Gross Profit | $1.02B | +12.2% | +49.3% | +88.9% | +51.0% | |
| $353.09M | -13.1% | +30.0% | +48.5% | +80.0% |
TTM Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 1Y | -$265.70M | -32.8% | |
| 3Y | -$265.70M | -32.8% | |
| 5Y | $18.83M | -1973.8% | |
| All | $365.89M | -196.4% |
TTM Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 1Y | -$471.61M | N/A | +25.2% |
| 3Y | -$555.61M | +36.5% | |
| 5Y | -$555.61M | +36.5% | |
| All | -$555.61M | +36.5% |
TTM Operating Profit History
FAQ
What is the current TTM operating profit of IONS?
As of today, IONS TTM operating profit is -$352.79M
What is IONS TTM operating profit most recent change?
IONS TTM operating profit was up +7.70% on March 31, 2026
What is 1-year change in IONS TTM operating profit?
IONS TTM operating profit is up +25.19% year-over-year
How far is IONS TTM operating profit from its all-time high?
IONS TTM operating profit is currently -196.42% below its historical high of $365.89M set on December 31, 2019
How does IONS TTM operating profit rank versus sector peers?
IONS TTM operating profit is higher than 3.85% of companies in Healthcare sector
When is IONS next earnings release?
The next earnings release for IONS is on
Operating Profit Formula
Operating Profit = Gross Profit −
Data Sources & References
- IONS Official Website www.ionis.com
- Most Recent Annual Report (10-K) www.sec.gov/Archives/edgar/data/874015/000087401526000115/0000874015-26-000115-index.htm
- IONS Profile on Yahoo Finance finance.yahoo.com/quote/IONS
- IONS Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/ions