Annual Operating Profit
-$475.11M$121.40M-34.32%
Summary
- Current Value
- As of today, IONS annual operating profit is -$475.11M, down -34.32% on
- Historical Performance
- IONS annual operating profit is down -3123.47% over the past 3 years, and down -229.85% over the past 5 years
- All-Time High Comparison
- IONS annual operating profit is currently -229.85% below its historical high of $365.88M set on
- 3-Year Low Comparison
- IONS annual operating profit is at its 3-year low
- Sector Comparison
- IONS annual operating profit is higher than 2.12% of companies in Healthcare sector
Operating Profit Chart
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Series
SUGGESTED SERIES
Performance
| Metric | Date | Value | 1Y | 3Y | 5Y | 15Y |
|---|---|---|---|---|---|---|
| Annual Operating Profit | -$475.11M | -34.3% | -3123.5% | -229.8% | -1625.3% | |
| Quarterly Operating Profit | -$160.18M | -7.8% | -170.8% | -338.4% | -1822.5% | |
| TTM Operating Profit | -$277.23M | +25.1% | -1572.4% | -349.2% | -542.1% | |
| Price | $79.48 | +127.5% | +99.5% | +33.2% | +700.4% | |
| PE Ratio | - | – | – | – | – | |
| Annual Revenue | $705.14M | -10.5% | -13.0% | -37.2% | +479.9% | |
| Annual EPS | -$3.04 | -18.7% | -1396.9% | -246.3% | -879.3% | |
| Annual Gross Profit | $671.93M | -11.1% | -13.9% | -39.0% | +100.0% | |
| Annual Operating Expenses | $1.17B | +3.3% | +43.5% | +55.4% | +683.9% |
Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 3Y | -$353.71M | -34.3% | |
| 5Y | -$14.74M | -3123.5% | |
| All | $365.88M | -229.8% |
Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 3Y | -$475.11M | at low | |
| 5Y | -$475.11M | at low | |
| All | -$475.11M | at low |
Operating Profit History
FAQ
What is the current annual operating profit of IONS?
As of today, IONS annual operating profit is -$475.11M
What is 1-year change in IONS annual operating profit?
IONS annual operating profit is down -34.32% year-over-year
What is 3-year change in IONS annual operating profit?
IONS annual operating profit is down -3123.47% over the past 3 years
How far is IONS annual operating profit from its all-time high?
IONS annual operating profit is currently -229.85% below its historical high of $365.88M set on December 31, 2019
How does IONS annual operating profit rank versus sector peers?
IONS annual operating profit is higher than 2.12% of companies in Healthcare sector
When is IONS next annual earnings release?
The next annual earnings release for IONS is on
Quarterly Operating Profit
-$160.18M$300.00M-214.57%
Summary
- Current Value
- As of today, IONS quarterly operating profit is -$160.18M, down -214.57% on
- Historical Performance
- IONS quarterly operating profit is down -7.75% year-over-year, and down -170.79% over the past 3 years
- All-Time High Comparison
- IONS quarterly operating profit is currently -161.45% below its historical high of $260.65M set on
- 3-Year Low Comparison
- IONS quarterly operating profit is +22.99% above its 3-year low of -$208.00M reached on an earlier date
- Sector Comparison
- IONS quarterly operating profit is higher than 1.43% of companies in Healthcare sector
Performance
| Metric | Date | Value | 3M | 1Y | 3Y | 5Y |
|---|---|---|---|---|---|---|
| Quarterly Operating Profit | -$160.18M | -214.6% | -7.8% | -170.8% | -338.4% | |
| Annual Operating Profit | -$475.11M | – | -34.3% | -3123.5% | -229.8% | |
| TTM Operating Profit | -$277.23M | -4.3% | +25.1% | -1572.4% | -349.2% | |
| Price | $79.48 | +12.6% | +127.5% | +99.5% | +33.2% | |
| PE Ratio | - | – | – | – | – | |
| Quarterly Revenue | $156.72M | -65.3% | +17.1% | -1.9% | -2.1% | |
| Quarterly EPS | -$0.81 | -218.8% | +14.8% | -143.2% | -359.7% | |
| Quarterly Gross Profit | $151.51M | -66.0% | +19.1% | -1.1% | -0.7% | |
| Quarterly Operating Expenses | $311.69M | +2.1% | +13.0% | +46.8% | +64.8% |
Quarterly Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 1Y | $139.82M | -214.6% | |
| 3Y | $139.82M | -214.6% | |
| 5Y | $221.00M | -172.5% | |
| All | $260.65M | -161.4% |
Quarterly Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 1Y | -$160.18M | at low | |
| 3Y | -$208.00M | N/A | +23.0% |
| 5Y | -$208.00M | +23.0% | |
| All | -$208.00M | +23.0% |
Quarterly Operating Profit History
FAQ
What is the current quarterly operating profit of IONS?
As of today, IONS quarterly operating profit is -$160.18M
What is IONS quarterly operating profit most recent change?
IONS quarterly operating profit was down -214.57% on September 1, 2025
What is 1-year change in IONS quarterly operating profit?
IONS quarterly operating profit is down -7.75% year-over-year
How far is IONS quarterly operating profit from its all-time high?
IONS quarterly operating profit is currently -161.45% below its historical high of $260.65M set on December 31, 2019
How does IONS quarterly operating profit rank versus sector peers?
IONS quarterly operating profit is higher than 1.43% of companies in Healthcare sector
When is IONS next earnings release?
The next earnings release for IONS is on
TTM Operating Profit
-$277.23M$11.53M-4.34%
Summary
- Current Value
- As of today, IONS TTM operating profit is -$277.23M, down -4.34% on
- Historical Performance
- IONS TTM operating profit is up +25.13% year-over-year, and down -1572.41% over the past 3 years
- All-Time High Comparison
- IONS TTM operating profit is currently -175.77% below its historical high of $365.89M set on
- 3-Year Low Comparison
- IONS TTM operating profit is +50.10% above its 3-year low of -$555.61M reached on
- Sector Comparison
- IONS TTM operating profit is higher than 4.65% of companies in Healthcare sector
Performance
| Metric | Date | Value | 3M | 1Y | 3Y | 5Y |
|---|---|---|---|---|---|---|
| TTM Operating Profit | -$277.23M | -4.3% | +25.1% | -1572.4% | -349.2% | |
| Annual Operating Profit | -$475.11M | – | -34.3% | -3123.5% | -229.8% | |
| Quarterly Operating Profit | -$160.18M | -214.6% | -7.8% | -170.8% | -338.4% | |
| Price | $79.48 | +12.6% | +127.5% | +99.5% | +33.2% | |
| PE Ratio | - | – | – | – | – | |
| TTM Revenue | $967.38M | +2.4% | +20.4% | +10.5% | +3.7% | |
| TTM EPS | -$1.71 | +7.6% | +29.9% | -1233.8% | -406.7% | |
| TTM Gross Profit | $939.02M | +2.6% | +21.8% | +11.4% | +3.6% | |
| Quarterly Operating Expenses | $311.69M | +2.1% | +13.0% | +46.8% | +64.8% |
TTM Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 1Y | -$265.70M | -4.3% | |
| 3Y | -$265.70M | -4.3% | |
| 5Y | $18.83M | -1572.4% | |
| All | $365.89M | -175.8% |
TTM Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 1Y | -$474.26M | N/A | +41.5% |
| 3Y | -$555.61M | +50.1% | |
| 5Y | -$555.61M | +50.1% | |
| All | -$555.61M | +50.1% |
TTM Operating Profit History
FAQ
What is the current TTM operating profit of IONS?
As of today, IONS TTM operating profit is -$277.23M
What is IONS TTM operating profit most recent change?
IONS TTM operating profit was down -4.34% on September 1, 2025
What is 1-year change in IONS TTM operating profit?
IONS TTM operating profit is up +25.13% year-over-year
How far is IONS TTM operating profit from its all-time high?
IONS TTM operating profit is currently -175.77% below its historical high of $365.89M set on December 31, 2019
How does IONS TTM operating profit rank versus sector peers?
IONS TTM operating profit is higher than 4.65% of companies in Healthcare sector
When is IONS next earnings release?
The next earnings release for IONS is on
Operating Profit Formula
Operating Profit = Gross Profit −
Data Sources & References
- IONS Official Website www.ionis.com
- Most Recent Annual Report (10-K) www.sec.gov/Archives/edgar/data/874015/000087401525000089/0000874015-25-000089-index.htm
- IONS Profile on Yahoo Finance finance.yahoo.com/quote/IONS
- IONS Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/ions