Annual Operating Profit
-$382.00M$93.08M+19.59%
Summary
- Current Value
- As of today, IONS annual operating profit is -$382.00M, up +19.59% on
- Historical Performance
- IONS annual operating profit is up +6.87% over the past 3 years, down -121.99% over the past 5 years
- All-Time High Comparison
- IONS annual operating profit is currently -204.40% below its historical high of $365.88M set on
- 3-Year Low Comparison
- IONS annual operating profit is +19.59% above its 3-year low of -$475.08M reached on
- Sector Comparison
- IONS annual operating profit is higher than 3.25% of companies in Healthcare sector
Operating Profit Chart
SUGGESTED SERIES
Performance
| Metric | Date | Value | 1Y | 3Y | 5Y | 15Y |
|---|---|---|---|---|---|---|
| Annual Operating Profit | -$382.00M | +19.6% | +6.9% | -122.0% | -715.3% | |
| Quarterly Operating Profit | -$102.29M | -173.2% | -13.4% | -40.2% | -639.1% | |
| TTM Operating Profit | -$594.90M | -123.9% | -26.2% | -165.0% | -1023.0% | |
| Price | $56.94 | +36.7% | +43.0% | +46.6% | +758.8% | |
| PE Ratio | - | – | – | – | – | |
| Annual Revenue | $943.71M | +33.8% | +60.7% | +29.4% | +770.0% | |
| Annual EPS | -$2.38 | +21.5% | -25.4% | +25.1% | -284.4% | |
| Annual Gross Profit | $928.00M | +38.1% | +68.4% | +32.5% | +100.0% | |
| $1.31B | +14.2% | +36.3% | +50.2% | +2695.8% |
Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 3Y | -$353.73M | -8.0% | |
| 5Y | -$30.19M | -1165.5% | |
| All | $365.88M | -204.4% |
Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 3Y | -$475.08M | +19.6% | |
| 5Y | -$475.08M | +19.6% | |
| All | -$475.08M | +19.6% |
Operating Profit History
FAQ
- What is the current annual operating profit of IONS?
- As of today, IONS annual operating profit is -$382.00M
- What is 1-year change in IONS annual operating profit?
- IONS annual operating profit is up +19.59% year-over-year
- What is 3-year change in IONS annual operating profit?
- IONS annual operating profit is up +6.87% over the past 3 years
- How far is IONS annual operating profit from its all-time high?
- IONS annual operating profit is currently -204.40% below its historical high of $365.88M set on December 31, 2019
- How does IONS annual operating profit rank versus sector peers?
- IONS annual operating profit is higher than 3.25% of companies in Healthcare sector
- When is IONS next annual earnings release?
- As of today, the next annual earnings release for IONS has not been scheduled
Operating Profit Formula
Operating Profit = Gross Profit −
Quarterly Operating Profit
-$102.29M$15.13M+12.89%
Summary
- Current Value
- As of today, IONS quarterly operating profit is -$102.29M, up +12.89% on
- Historical Performance
- IONS quarterly operating profit is down -173.16% year-over-year, down -13.41% over the past 3 years
- All-Time High Comparison
- IONS quarterly operating profit is currently -139.24% below its historical high of $260.65M set on
- 3-Year Low Comparison
- IONS quarterly operating profit is +52.42% above its 3-year low of -$215.00M reached on
- Sector Comparison
- IONS quarterly operating profit is higher than 3.08% of companies in Healthcare sector
Performance
| Metric | Date | Value | 3M | 1Y | 3Y | 5Y |
|---|---|---|---|---|---|---|
| Quarterly Operating Profit | -$102.29M | +12.9% | -173.2% | -13.4% | -40.2% | |
| Annual Operating Profit | -$382.00M | – | +19.6% | +6.9% | -122.0% | |
| TTM Operating Profit | -$594.90M | -68.6% | -123.9% | -26.2% | -165.0% | |
| Price | $56.94 | -24.8% | +36.7% | +43.0% | +46.6% | |
| PE Ratio | - | – | – | – | – | |
| Quarterly Revenue | $267.95M | +8.9% | -40.7% | +42.2% | +113.1% | |
| Quarterly EPS | -$0.69 | -23.5% | -202.3% | -16.3% | -20.8% | |
| Quarterly Gross Profit | $257.57M | +9.3% | -42.1% | +43.0% | +118.7% | |
| $359.87M | +1.9% | +17.9% | +33.1% | +88.7% |
Quarterly Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 1Y | $139.82M | N/A | -173.2% |
| 3Y | $139.82M | -173.2% | |
| 5Y | $221.00M | -146.3% | |
| All | $260.65M | -139.2% |
Quarterly Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 1Y | -$215.00M | +52.4% | |
| 3Y | -$215.00M | +52.4% | |
| 5Y | -$215.00M | +52.4% | |
| All | -$215.00M | +52.4% |
Quarterly Operating Profit History
FAQ
- What is the current quarterly operating profit of IONS?
- As of today, IONS quarterly operating profit is -$102.29M
- What is IONS quarterly operating profit most recent change?
- IONS quarterly operating profit was up +12.89% on June 30, 2026
- What is 1-year change in IONS quarterly operating profit?
- IONS quarterly operating profit is down -173.16% year-over-year
- How far is IONS quarterly operating profit from its all-time high?
- IONS quarterly operating profit is currently -139.24% below its historical high of $260.65M set on December 31, 2019
- How does IONS quarterly operating profit rank versus sector peers?
- IONS quarterly operating profit is higher than 3.08% of companies in Healthcare sector
- When is IONS next earnings release?
- The next earnings release for IONS is on
Operating Profit Formula
Operating Profit = Gross Profit −
TTM Operating Profit
-$594.90M$242.11M-68.63%
Summary
- Current Value
- As of today, IONS TTM operating profit is -$594.90M, down -68.63% on
- Historical Performance
- IONS TTM operating profit is down -123.90% year-over-year, down -26.17% over the past 3 years
- All-Time High Comparison
- IONS TTM operating profit is currently -262.59% below its historical high of $365.89M set on
- 3-Year Low Comparison
- IONS TTM operating profit is at its 3-year low
- Sector Comparison
- IONS TTM operating profit is higher than 0.93% of companies in Healthcare sector
Performance
| Metric | Date | Value | 3M | 1Y | 3Y | 5Y |
|---|---|---|---|---|---|---|
| TTM Operating Profit | -$594.90M | -68.6% | -123.9% | -26.2% | -165.0% | |
| Annual Operating Profit | -$382.00M | – | +19.6% | +6.9% | -122.0% | |
| Quarterly Operating Profit | -$102.29M | +12.9% | -173.2% | -13.4% | -40.2% | |
| Price | $56.94 | -24.8% | +36.7% | +43.0% | +46.6% | |
| PE Ratio | - | – | – | – | – | |
| TTM Revenue | $873.76M | -17.4% | -7.5% | +38.5% | +27.1% | |
| TTM EPS | -$3.47 | -65.2% | -87.5% | -60.5% | +11.5% | |
| TTM Gross Profit | $835.84M | -18.3% | -8.6% | +39.8% | +27.2% | |
| $359.87M | +1.9% | +17.9% | +33.1% | +88.7% |
TTM Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 1Y | -$265.70M | N/A | -123.9% |
| 3Y | -$265.70M | -123.9% | |
| 5Y | $18.83M | -3259.7% | |
| All | $365.89M | -262.6% |
TTM Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 1Y | -$594.90M | at low | |
| 3Y | -$594.90M | at low | |
| 5Y | -$594.90M | at low | |
| All | -$594.90M | at low |
TTM Operating Profit History
FAQ
- What is the current TTM operating profit of IONS?
- As of today, IONS TTM operating profit is -$594.90M
- What is IONS TTM operating profit most recent change?
- IONS TTM operating profit was down -68.63% on June 30, 2026
- What is 1-year change in IONS TTM operating profit?
- IONS TTM operating profit is down -123.90% year-over-year
- How far is IONS TTM operating profit from its all-time high?
- IONS TTM operating profit is currently -262.59% below its historical high of $365.89M set on December 31, 2019
- How does IONS TTM operating profit rank versus sector peers?
- IONS TTM operating profit is higher than 0.93% of companies in Healthcare sector
- When is IONS next earnings release?
- The next earnings release for IONS is on
Operating Profit Formula
Operating Profit = Gross Profit −
Data Sources & References
- IONS Official Website www.ionis.com
- Most Recent Annual Report (10-K) www.sec.gov/Archives/edgar/data/874015/000087401526000115/0000874015-26-000115-index.htm
- IONS Profile on Yahoo Finance finance.yahoo.com/quote/IONS
- IONS Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/ions