Annual Operating Profit:
-$475.11M-$121.40M(-34.32%)Summary
- As of today, IONS annual operating income is -$475.11 million, with the most recent change of -$121.40 million (-34.32%) on December 31, 2024.
- During the last 3 years, IONS annual operating profit has fallen by -$460.37 million (-3123.47%).
- IONS annual operating profit is now -229.85% below its all-time high of $365.88 million, reached on December 31, 2019.
Performance
IONS Operating Profit Chart
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Quarterly Operating Profit:
-$160.18M-$300.00M(-214.57%)Summary
- As of today, IONS quarterly operating income is -$160.18 million, with the most recent change of -$300.00 million (-214.57%) on September 1, 2025.
- Over the past year, IONS quarterly operating profit has dropped by -$11.53 million (-7.75%).
- IONS quarterly operating profit is now -161.45% below its all-time high of $260.65 million, reached on December 31, 2019.
Performance
IONS Quarterly Operating Profit Chart
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TTM Operating Profit:
-$277.23M-$11.53M(-4.34%)Summary
- As of today, IONS TTM operating income is -$277.23 million, with the most recent change of -$11.53 million (-4.34%) on September 1, 2025.
- Over the past year, IONS TTM operating profit has increased by +$93.03 million (+25.13%).
- IONS TTM operating profit is now -175.77% below its all-time high of $365.88 million, reached on December 31, 2019.
Performance
IONS TTM Operating Profit Chart
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Operating Profit Formula
Operating Profit = Gross Profit − Operating Expenses
IONS Operating Profit Trends
| PeriodPeriod | AnnualAnnual | QuarterlyQuarterly | TTMTTM |
|---|---|---|---|
| 1Y1 Year | -34.3% | -7.8% | +25.1% |
| 3Y3 Years | -3123.5% | -170.8% | -1572.4% |
| 5Y5 Years | -229.8% | -338.4% | -349.2% |
IONS Operating Profit Highs & Lows
| PeriodPeriod | Annual vs HighAnnual vs High | Annual vs LowAnnual vs Low | Quarter. vs HighQuarter. vs High | Quarter. vs LowQuarter. vs Low | TTM vs HighTTM vs High | TTM vs LowTTM vs Low | |
|---|---|---|---|---|---|---|---|
| 3Y | 3-Year | -3123.5% | at low | -214.6% | +23.0% | -1572.4% | +50.1% |
| 5Y | 5-Year | -229.8% | at low | -172.5% | +23.0% | -349.2% | +50.1% |
| All-Time | All-Time | -229.8% | at low | -161.4% | +23.0% | -175.8% | +50.1% |
IONS Operating Profit History
| Date | Annual | Quarterly | TTM |
|---|---|---|---|
| Sep 2025 | - | -$160.18M(-214.6%) | -$277.23M(-4.3%) |
| Jun 2025 | - | $139.82M(+195.2%) | -$265.70M(+43.7%) |
| Mar 2025 | - | -$146.86M(-33.5%) | -$471.61M(+0.6%) |
| Dec 2024 | -$475.11M(-34.3%) | -$110.00M(+26.0%) | -$474.26M(-28.1%) |
| Sep 2024 | - | -$148.66M(-124.9%) | -$370.26M(-1.5%) |
| Jun 2024 | - | -$66.09M(+55.8%) | -$364.87M(+6.2%) |
| Mar 2024 | - | -$149.51M(-2391.9%) | -$388.97M(-10.0%) |
| Dec 2023 | -$353.71M(+13.8%) | -$6.00M(+95.8%) | -$353.61M(+36.4%) |
| Sep 2023 | - | -$143.26M(-58.8%) | -$555.61M(-17.8%) |
| Jun 2023 | - | -$90.19M(+21.0%) | -$471.50M(-1.0%) |
| Mar 2023 | - | -$114.15M(+45.1%) | -$466.82M(-13.8%) |
| Dec 2022 | -$410.19M(-2683.0%) | -$208.00M(-251.6%) | -$410.17M(-2278.5%) |
| Sep 2022 | - | -$59.15M(+30.8%) | $18.83M(+339.3%) |
| Jun 2022 | - | -$85.51M(-48.7%) | -$7.87M(-268.2%) |
| Mar 2022 | - | -$57.50M(-126.0%) | $4.68M(+115.7%) |
| Dec 2021 | -$14.74M(+90.2%) | $221.00M(+357.4%) | -$29.79M(+89.1%) |
| Sep 2021 | - | -$85.85M(-17.7%) | -$273.79M(-22.0%) |
| Jun 2021 | - | -$72.97M(+20.7%) | -$224.48M(-10.4%) |
| Mar 2021 | - | -$91.97M(-299.9%) | -$203.26M(-17.9%) |
| Dec 2020 | -$149.96M(-141.0%) | -$23.00M(+37.1%) | -$172.42M(-255.0%) |
| Sep 2020 | - | -$36.54M(+29.4%) | $111.24M(-26.0%) |
| Jun 2020 | - | -$51.75M(+15.3%) | $150.30M(-18.0%) |
| Mar 2020 | - | -$61.13M(-123.5%) | $183.22M(-49.9%) |
| Dec 2019 | $365.88M(+696.2%) | $260.65M(>+9900.0%) | $365.88M(+215.4%) |
| Sep 2019 | - | $2.52M(+113.4%) | $116.01M(+22.2%) |
| Jun 2019 | - | -$18.83M(-115.5%) | $94.92M(+49.6%) |
| Mar 2019 | - | $121.53M(+1027.2%) | $63.46M(+203.4%) |
| Dec 2018 | -$61.37M(-297.7%) | $10.78M(+158.1%) | -$61.37M(+21.7%) |
| Sep 2018 | - | -$18.57M(+63.1%) | -$78.35M(-61.7%) |
| Jun 2018 | - | -$50.28M(-1423.2%) | -$48.47M(-686.7%) |
| Mar 2018 | - | -$3.30M(+46.8%) | $8.26M(-73.4%) |
| Dec 2017 | $31.05M(+254.0%) | -$6.20M(-154.8%) | $31.05M(-60.4%) |
| Sep 2017 | - | $11.31M(+75.4%) | $78.40M(-6.6%) |
| Jun 2017 | - | $6.45M(-66.9%) | $83.90M(+193.1%) |
| Mar 2017 | - | $19.48M(-52.7%) | $28.62M(+163.4%) |
| Dec 2016 | -$20.16M(+73.4%) | $41.16M(+144.9%) | -$45.12M(+69.8%) |
| Sep 2016 | - | $16.81M(+134.4%) | -$149.21M(+30.3%) |
| Jun 2016 | - | -$48.83M(+10.0%) | -$214.16M(-77.5%) |
| Mar 2016 | - | -$54.25M(+13.8%) | -$120.68M(-59.3%) |
| Dec 2015 | -$75.76M(-58.7%) | -$62.94M(-30.7%) | -$75.76M(-2663.0%) |
| Sep 2015 | - | -$48.14M(-207.8%) | -$2.74M(-111.5%) |
| Jun 2015 | - | $44.65M(+578.5%) | $23.90M(+187.3%) |
| Mar 2015 | - | -$9.33M(-192.6%) | -$27.39M(+42.6%) |
| Dec 2014 | -$47.73M(+7.6%) | $10.08M(+146.9%) | -$47.73M(+38.5%) |
| Sep 2014 | - | -$21.49M(-223.2%) | -$77.67M(+4.9%) |
| Jun 2014 | - | -$6.65M(+77.6%) | -$81.68M(+1.5%) |
| Mar 2014 | - | -$29.67M(-49.4%) | -$82.96M(-60.6%) |
| Dec 2013 | -$51.67M(+25.0%) | -$19.86M(+22.1%) | -$51.67M(+10.6%) |
| Sep 2013 | - | -$25.50M(-221.7%) | -$57.77M(+3.6%) |
| Jun 2013 | - | -$7.93M(-587.9%) | -$59.94M(-24.6%) |
| Mar 2013 | - | $1.63M(+106.3%) | -$48.09M(+30.6%) |
| Dec 2012 | -$68.92M(+3.1%) | -$25.97M(+6.2%) | -$69.31M(-15.7%) |
| Sep 2012 | - | -$27.67M(-805.3%) | -$59.92M(-10.1%) |
| Jun 2012 | - | $3.92M(+120.0%) | -$54.41M(+24.6%) |
| Mar 2012 | - | -$19.59M(-18.2%) | -$72.17M(-6.9%) |
| Dec 2011 | -$71.10M(-47.0%) | -$16.58M(+25.1%) | -$67.52M(-1.1%) |
| Sep 2011 | - | -$22.15M(-60.0%) | -$66.79M(-26.1%) |
| Jun 2011 | - | -$13.84M(+7.4%) | -$52.97M(+7.9%) |
| Mar 2011 | - | -$14.94M(+5.8%) | -$57.49M(-21.4%) |
| Dec 2010 | -$48.36M(-75.6%) | -$15.86M(-90.3%) | -$47.36M(-9.7%) |
| Sep 2010 | - | -$8.33M(+54.6%) | -$43.17M(+4.6%) |
| Jun 2010 | - | -$18.36M(-281.4%) | -$45.24M(-42.7%) |
| Mar 2010 | - | -$4.81M(+58.8%) | -$31.71M(-15.1%) |
| Dec 2009 | -$27.54M(-110.9%) | -$11.67M(-12.3%) | -$27.54M(-117.9%) |
| Sep 2009 | - | -$10.40M(-115.4%) | -$12.64M(-92.5%) |
| Jun 2009 | - | -$4.83M(-651.9%) | -$6.57M(-34.8%) |
| Mar 2009 | - | -$642.00K(-119.9%) | -$4.87M(+62.7%) |
| Dec 2008 | -$13.06M(+60.3%) | $3.23M(+174.7%) | -$13.06M(+47.2%) |
| Sep 2008 | - | -$4.32M(-38.0%) | -$24.73M(+33.3%) |
| Jun 2008 | - | -$3.13M(+64.5%) | -$37.06M(+30.8%) |
| Mar 2008 | - | -$8.83M(-4.6%) | -$53.59M(+18.4%) |
| Date | Annual | Quarterly | TTM |
|---|---|---|---|
| Dec 2007 | -$32.92M(+49.9%) | -$8.44M(+49.3%) | -$65.66M(+11.3%) |
| Sep 2007 | - | -$16.65M(+15.3%) | -$74.03M(+2.5%) |
| Jun 2007 | - | -$19.66M(+5.9%) | -$75.92M(-3.2%) |
| Mar 2007 | - | -$20.90M(-24.3%) | -$73.58M(-7.2%) |
| Dec 2006 | -$65.75M(-30.9%) | -$16.82M(+9.3%) | -$68.66M(-12.8%) |
| Sep 2006 | - | -$18.54M(-7.1%) | -$60.87M(-11.0%) |
| Jun 2006 | - | -$17.32M(-8.4%) | -$54.82M(-10.1%) |
| Mar 2006 | - | -$15.98M(-76.9%) | -$49.78M(+0.9%) |
| Dec 2005 | -$50.22M(+41.2%) | -$9.03M(+27.7%) | -$50.22M(+17.1%) |
| Sep 2005 | - | -$12.49M(-1.8%) | -$60.56M(+14.6%) |
| Jun 2005 | - | -$12.27M(+25.3%) | -$70.91M(+15.0%) |
| Mar 2005 | - | -$16.42M(+15.2%) | -$83.40M(+6.6%) |
| Dec 2004 | -$85.43M(-10.7%) | -$19.37M(+15.2%) | -$89.31M(+2.3%) |
| Sep 2004 | - | -$22.85M(+7.7%) | -$91.42M(-4.3%) |
| Jun 2004 | - | -$24.76M(-10.9%) | -$87.64M(-8.7%) |
| Mar 2004 | - | -$22.34M(-4.0%) | -$80.60M(-4.4%) |
| Dec 2003 | -$77.17M(-56.1%) | -$21.48M(-12.7%) | -$77.18M(-17.7%) |
| Sep 2003 | - | -$19.07M(-7.6%) | -$65.57M(-2.4%) |
| Jun 2003 | - | -$17.72M(+6.3%) | -$64.01M(-9.2%) |
| Mar 2003 | - | -$18.91M(-91.6%) | -$58.63M(-18.6%) |
| Dec 2002 | -$49.44M(-7.2%) | -$9.87M(+43.6%) | -$49.44M(-25.0%) |
| Sep 2002 | - | -$17.51M(-41.9%) | -$39.57M(-47.8%) |
| Jun 2002 | - | -$12.34M(-27.0%) | -$26.76M(+13.4%) |
| Mar 2002 | - | -$9.72M(-106.5%) | -$30.89M(+35.5%) |
| Dec 2001 | -$46.10M(-59.0%) | - | - |
| Sep 2001 | - | -$4.71M(+71.4%) | -$47.86M(-11.8%) |
| Jun 2001 | - | -$16.46M(+4.5%) | -$42.80M(-24.0%) |
| Mar 2001 | - | -$17.23M(-82.3%) | -$34.51M(-22.0%) |
| Dec 2000 | -$28.99M(+32.7%) | -$9.45M(-2770.1%) | -$28.28M(+9.6%) |
| Sep 2000 | - | $354.00K(+104.3%) | -$31.30M(+21.2%) |
| Jun 2000 | - | -$8.18M(+25.7%) | -$39.69M(+8.7%) |
| Mar 2000 | - | -$11.01M(+11.7%) | -$43.49M(-1.1%) |
| Dec 1999 | -$43.10M(-32.6%) | -$12.47M(-55.0%) | -$43.04M(+1.2%) |
| Sep 1999 | - | -$8.04M(+32.9%) | -$43.57M(-30.1%) |
| Jun 1999 | - | -$11.98M(-13.5%) | -$33.50M(-0.7%) |
| Mar 1999 | - | -$10.55M(+18.8%) | -$33.27M(-2.3%) |
| Dec 1998 | -$32.50M(-3.8%) | -$13.00M(-741.3%) | -$32.54M(-9.0%) |
| Sep 1998 | - | $2.03M(+117.3%) | -$29.84M(+13.4%) |
| Jun 1998 | - | -$11.74M(-19.6%) | -$34.47M(-6.3%) |
| Mar 1998 | - | -$9.82M(+4.6%) | -$32.42M(-2.9%) |
| Dec 1997 | -$31.30M(-7.6%) | -$10.30M(-296.2%) | -$31.50M(-2.6%) |
| Sep 1997 | - | -$2.60M(+73.2%) | -$30.70M(+11.8%) |
| Jun 1997 | - | -$9.70M(-9.0%) | -$34.80M(-4.8%) |
| Mar 1997 | - | -$8.90M(+6.3%) | -$33.20M(-14.1%) |
| Dec 1996 | -$29.10M(-13.7%) | -$9.50M(-41.8%) | -$29.10M(-12.8%) |
| Sep 1996 | - | -$6.70M(+17.3%) | -$25.80M(+2.6%) |
| Jun 1996 | - | -$8.10M(-68.8%) | -$26.50M(-8.6%) |
| Mar 1996 | - | -$4.80M(+22.6%) | -$24.40M(+5.1%) |
| Dec 1995 | -$25.60M(-13.8%) | -$6.20M(+16.2%) | -$25.70M(+16.3%) |
| Sep 1995 | - | -$7.40M(-23.3%) | -$30.70M(-8.5%) |
| Jun 1995 | - | -$6.00M(+1.6%) | -$28.30M(-4.4%) |
| Mar 1995 | - | -$6.10M(+45.5%) | -$27.10M(-6.3%) |
| Dec 1994 | -$22.50M(-23.0%) | -$11.20M(-124.0%) | -$25.50M(-36.4%) |
| Sep 1994 | - | -$5.00M(-4.2%) | -$18.70M(-3.3%) |
| Jun 1994 | - | -$4.80M(-6.7%) | -$18.10M(-1.1%) |
| Mar 1994 | - | -$4.50M(-2.3%) | -$17.90M(+3.2%) |
| Dec 1993 | -$18.30M(+15.3%) | -$4.40M(0.0%) | -$18.50M(+14.0%) |
| Sep 1993 | - | -$4.40M(+4.3%) | -$21.50M(+2.3%) |
| Jun 1993 | - | -$4.60M(+9.8%) | -$22.00M(-1.9%) |
| Mar 1993 | - | -$5.10M(+31.1%) | -$21.60M(-0.5%) |
| Dec 1992 | -$21.60M(-105.7%) | -$7.40M(-51.0%) | -$21.50M(-12.6%) |
| Sep 1992 | - | -$4.90M(-16.7%) | -$19.10M(-15.1%) |
| Jun 1992 | - | -$4.20M(+16.0%) | -$16.60M(-12.9%) |
| Mar 1992 | - | -$5.00M(0.0%) | -$14.70M(-33.6%) |
| Dec 1991 | -$10.50M(-133.3%) | -$5.00M(-108.3%) | -$11.00M(+8.3%) |
| Sep 1991 | - | -$2.40M(-4.3%) | -$12.00M(-31.9%) |
| Jun 1991 | - | -$2.30M(-76.9%) | -$9.10M(-44.4%) |
| Mar 1991 | - | -$1.30M(+78.3%) | -$6.30M(-40.0%) |
| Dec 1990 | -$4.50M | -$6.00M(-1300.0%) | -$4.50M(-400.0%) |
| Sep 1990 | - | $500.00K(0.0%) | $1.50M(+50.0%) |
| Jun 1990 | - | $500.00K(0.0%) | $1.00M(+100.0%) |
| Mar 1990 | - | $500.00K | $500.00K |
FAQ
- What is Ionis Pharmaceuticals, Inc. annual operating income?
- What is the all-time high annual operating profit for Ionis Pharmaceuticals, Inc.?
- What is Ionis Pharmaceuticals, Inc. annual operating profit year-on-year change?
- What is Ionis Pharmaceuticals, Inc. quarterly operating income?
- What is the all-time high quarterly operating profit for Ionis Pharmaceuticals, Inc.?
- What is Ionis Pharmaceuticals, Inc. quarterly operating profit year-on-year change?
- What is Ionis Pharmaceuticals, Inc. TTM operating income?
- What is the all-time high TTM operating profit for Ionis Pharmaceuticals, Inc.?
- What is Ionis Pharmaceuticals, Inc. TTM operating profit year-on-year change?
What is Ionis Pharmaceuticals, Inc. annual operating income?
The current annual operating profit of IONS is -$475.11M
What is the all-time high annual operating profit for Ionis Pharmaceuticals, Inc.?
Ionis Pharmaceuticals, Inc. all-time high annual operating income is $365.88M
What is Ionis Pharmaceuticals, Inc. annual operating profit year-on-year change?
Over the past year, IONS annual operating income has changed by -$121.40M (-34.32%)
What is Ionis Pharmaceuticals, Inc. quarterly operating income?
The current quarterly operating profit of IONS is -$160.18M
What is the all-time high quarterly operating profit for Ionis Pharmaceuticals, Inc.?
Ionis Pharmaceuticals, Inc. all-time high quarterly operating income is $260.65M
What is Ionis Pharmaceuticals, Inc. quarterly operating profit year-on-year change?
Over the past year, IONS quarterly operating income has changed by -$11.53M (-7.75%)
What is Ionis Pharmaceuticals, Inc. TTM operating income?
The current TTM operating profit of IONS is -$277.23M
What is the all-time high TTM operating profit for Ionis Pharmaceuticals, Inc.?
Ionis Pharmaceuticals, Inc. all-time high TTM operating income is $365.88M
What is Ionis Pharmaceuticals, Inc. TTM operating profit year-on-year change?
Over the past year, IONS TTM operating income has changed by +$93.03M (+25.13%)