What is the current annual EBITDA of IONS?

As of today, IONS annual EBITDA is -$358.99M

What is 1-year change in IONS annual EBITDA?

IONS annual EBITDA is up +20.77% year-over-year

What is 3-year change in IONS annual EBITDA?

IONS annual EBITDA is up +7.50% over the past 3 years

How far is IONS annual EBITDA from its all-time high?

IONS annual EBITDA is currently -194.01% below its historical high of $381.88M set on December 31, 2019

How does IONS annual EBITDA rank versus sector peers?

IONS annual EBITDA is higher than 3.51% of companies in Healthcare sector

When is IONS next annual earnings release?

As of today, the next annual earnings release for IONS has not been scheduled

What is the current quarterly EBITDA of IONS?

As of today, IONS quarterly EBITDA is -$94.66M

What is IONS quarterly EBITDA most recent change?

IONS quarterly EBITDA was up +13.93% on June 30, 2026

What is 1-year change in IONS quarterly EBITDA?

IONS quarterly EBITDA is down -165.16% year-over-year

How far is IONS quarterly EBITDA from its all-time high?

IONS quarterly EBITDA is currently -135.76% below its historical high of $264.73M set on December 31, 2019

How does IONS quarterly EBITDA rank versus sector peers?

IONS quarterly EBITDA is higher than 3.43% of companies in Healthcare sector

When is IONS next earnings release?

The next earnings release for IONS is on November 4, 2026

What is the current TTM EBITDA of IONS?

As of today, IONS TTM EBITDA is -$567.97M

What is IONS TTM EBITDA most recent change?

IONS TTM EBITDA was down -73.14% on June 30, 2026

What is 1-year change in IONS TTM EBITDA?

IONS TTM EBITDA is down -132.69% year-over-year

How far is IONS TTM EBITDA from its all-time high?

IONS TTM EBITDA is currently -249.13% below its historical high of $380.84M set on December 31, 2019

How does IONS TTM EBITDA rank versus sector peers?

IONS TTM EBITDA is higher than 0.95% of companies in Healthcare sector

When is IONS next earnings release?

The next earnings release for IONS is on November 4, 2026

IONS EBITDA History & Chart Since 1990

Annual EBITDA

-$358.99M$94.10M+20.77%

December 31, 2025

Summary

Current Value: As of today, IONS annual EBITDA is -$358.99M, up +20.77% on December 31, 2025
Historical Performance: IONS annual EBITDA is up +7.50% over the past 3 years, down -131.72% over the past 5 years
All-Time High Comparison: IONS annual EBITDA is currently -194.01% below its historical high of $381.88M set on December 31, 2019
3-Year Low Comparison: IONS annual EBITDA is +20.77% above its 3-year low of -$453.09M reached on December 31, 2024
Sector Comparison: IONS annual EBITDA is higher than 3.51% of companies in Healthcare sector

EBITDA Chart

beforeafter

Performance

IONS Performance
Metric	Date	Value	1Y	3Y	5Y	15Y
Annual EBITDA	Dec 31, 25	-$358.99M	+20.8%	+7.5%	-131.7%	-852.8%
Quarterly EBITDA	Jun 30, 26	-$94.66M	-165.2%	-12.0%	-39.3%	-875.0%
TTM EBITDA	Jun 30, 26	-$567.97M	-132.7%	-26.8%	-176.3%	-2683.1%
Price	Aug 7, 26	$56.56	+35.8%	+42.0%	+45.6%	+753.1%
PE Ratio	Aug 7, 26	-	–	–	–	–
Annual Revenue	Dec 31, 25	$943.71M	+33.8%	+60.7%	+29.4%	+770.0%
Annual EPS	Dec 31, 25	-$2.38	+21.5%	-25.4%	+25.1%	-284.4%
	Dec 31, 25	-$382.00M	+19.6%	+6.9%	-122.0%	-715.3%
Annual Net Income	Dec 31, 25	-$381.39M	+16.0%	-41.4%	+20.5%	-522.7%

EBITDA Highs

IONS Annual EBITDA Highs Comparison
Period	High	Date	Current
3Y	-$331.23M	Dec 31, 23	-8.4%
5Y	-$10.63M	Dec 31, 21	-3278.4%
All	$381.88M	Dec 31, 19	-194.0%

EBITDA Lows

IONS Annual EBITDA Lows Comparison
Period	Low	Date	Current
3Y	-$453.09M	Dec 31, 24	+20.8%
5Y	-$453.09M	Dec 31, 24	+20.8%
All	-$453.09M	Dec 31, 24	+20.8%

EBITDA History

Year	Value	Change
2025	-$358.99M	+20.8%
2024	-$453.09M	-36.8%
2023	-$331.23M	+14.6%
2022	-$388.09M	-3,552.2%
2021	-$10.63M	+93.1%
2020	-$154.92M	-140.6%
2019	$381.88M	+894.8%
2018	-$48.04M	-220.7%
2017	$39.80M	+213.7%
2016	-$34.99M	+45.0%
2015	-$63.64M	-66.1%
2014	-$38.33M	+8.5%
2013	-$41.88M	+27.0%
2012	-$57.35M	+0.1%
2011	-$57.42M	-52.4%
2010	-$37.68M	-106.6%
2009	-$18.24M	-192.1%
2008	-$6.24M	+80.7%

Year	Value	Change
2007	-$32.32M	+46.9%
2006	-$60.83M	-48.1%
2005	-$41.08M	+43.9%
2004	-$73.26M	-12.8%
2003	-$64.92M	-65.9%
2002	-$39.14M	-0.0%
2001	-$39.14M	-65.6%
2000	-$23.64M	+37.6%
1999	-$37.86M	-33.9%
1998	-$28.28M	+0.3%
1997	-$28.37M	-6.3%
1996	-$26.69M	-17.1%
1995	-$22.80M	-23.2%
1994	-$18.51M	-12.0%
1993	-$16.52M	+15.6%
1992	-$19.56M	-104.2%
1991	-$9.58M	-133.7%
1990	-$4.10M	-

FAQ

What is the current annual EBITDA of IONS?: As of today, IONS annual EBITDA is -$358.99M
What is 1-year change in IONS annual EBITDA?: IONS annual EBITDA is up +20.77% year-over-year
What is 3-year change in IONS annual EBITDA?: IONS annual EBITDA is up +7.50% over the past 3 years
How far is IONS annual EBITDA from its all-time high?: IONS annual EBITDA is currently -194.01% below its historical high of $381.88M set on December 31, 2019
How does IONS annual EBITDA rank versus sector peers?: IONS annual EBITDA is higher than 3.51% of companies in Healthcare sector
When is IONS next annual earnings release?: As of today, the next annual earnings release for IONS has not been scheduled

EBITDA Formula

EBITDA = Net Income + + +

Quarterly EBITDA

-$94.66M$15.32M+13.93%

June 30, 2026

Summary

Current Value: As of today, IONS quarterly EBITDA is -$94.66M, up +13.93% on June 30, 2026
Historical Performance: IONS quarterly EBITDA is down -165.16% year-over-year, down -12.01% over the past 3 years
All-Time High Comparison: IONS quarterly EBITDA is currently -135.76% below its historical high of $264.73M set on December 31, 2019
3-Year Low Comparison: IONS quarterly EBITDA is +54.42% above its 3-year low of -$207.66M reached on December 31, 2025
Sector Comparison: IONS quarterly EBITDA is higher than 3.43% of companies in Healthcare sector

Performance

IONS Performance
Metric	Date	Value	3M	1Y	3Y	5Y
Quarterly EBITDA	Jun 30, 26	-$94.66M	+13.9%	-165.2%	-12.0%	-39.3%
Annual EBITDA	Dec 31, 25	-$358.99M	–	+20.8%	+7.5%	-131.7%
TTM EBITDA	Jun 30, 26	-$567.97M	-73.1%	-132.7%	-26.8%	-176.3%
Price	Aug 7, 26	$56.56	-25.3%	+35.8%	+42.0%	+45.6%
PE Ratio	Aug 7, 26	-	–	–	–	–
Quarterly Revenue	Jun 30, 26	$267.95M	+8.9%	-40.7%	+42.2%	+113.1%
Quarterly EPS	Jun 30, 26	-$0.69	-23.5%	-202.3%	-16.3%	-20.8%
	Jun 30, 26	-$102.00M	+13.1%	-172.9%	-13.1%	-39.8%
Quarterly Net Income	Jun 30, 26	-$114.65M	-23.9%	-192.8%	-34.4%	-41.8%

Quarterly EBITDA Highs

IONS Quarterly EBITDA Highs Comparison
Period	High	Date	Current
1Y	$145.27M	N/A	-165.2%
3Y	$145.27M	Jun 30, 25	-165.2%
5Y	$225.98M	Dec 31, 21	-141.9%
All	$264.73M	Dec 31, 19	-135.8%

Quarterly EBITDA Lows

IONS Quarterly EBITDA Lows Comparison
Period	Low	Date	Current
1Y	-$207.66M	Dec 31, 25	+54.4%
3Y	-$207.66M	Dec 31, 25	+54.4%
5Y	-$207.66M	Dec 31, 25	+54.4%
All	-$207.66M	Dec 31, 25	+54.4%

Quarterly EBITDA History

Month	Value	Change
Jun 2026	-$94.66M	+13.9%
Mar 2026	-$109.98M	+47.0%
Dec 2025	-$207.66M	-33.4%
Sep 2025	-$155.68M	-207.2%
Jun 2025	$145.27M	+202.7%
Mar 2025	-$141.46M	-35.1%
Dec 2024	-$104.73M	+26.8%
Sep 2024	-$143.16M	-136.6%
Jun 2024	-$60.51M	+57.9%
Mar 2024	-$143.86M	>-9,900.0%
Dec 2023	-$388.00K	+99.7%
Sep 2023	-$137.67M	-62.9%
Jun 2023	-$84.51M	+22.1%
Mar 2023	-$108.54M	+46.0%
Dec 2022	-$200.97M	-271.8%
Sep 2022	-$54.06M	+32.8%
Jun 2022	-$80.43M	-52.9%
Mar 2022	-$52.61M	-123.3%
Dec 2021	$225.98M	+378.5%
Sep 2021	-$81.14M	-19.4%
Jun 2021	-$67.96M	+22.0%
Mar 2021	-$87.12M	-372.6%
Dec 2020	-$18.44M	+42.5%
Sep 2020	-$32.09M	+32.8%
Jun 2020	-$47.72M	+16.3%
Mar 2020	-$57.02M	-121.5%
Dec 2019	$264.73M	+4,167.1%
Sep 2019	$6.20M	+140.9%
Jun 2019	-$15.17M	-112.1%
Mar 2019	$125.08M	+774.4%
Dec 2018	$14.30M	+193.4%
Sep 2018	-$15.32M	+67.6%
Jun 2018	-$47.33M	-9,462.4%
Mar 2018	-$495.00K	+90.5%
Dec 2017	-$5.21M	-137.5%
Sep 2017	$13.87M	+56.4%
Jun 2017	$8.87M	-59.4%
Mar 2017	$21.86M	-49.7%
Dec 2016	$43.42M	+127.6%
Sep 2016	$19.08M	+141.0%
Jun 2016	-$46.56M	+10.5%
Mar 2016	-$52.03M	+13.7%
Dec 2015	-$60.31M	-32.5%
Sep 2015	-$45.52M	-196.3%
Jun 2015	$47.29M	+777.6%
Mar 2015	-$6.98M	-156.1%
Dec 2014	$12.44M	+165.2%
Sep 2014	-$19.07M	-341.5%
Jun 2014	-$4.32M	+84.2%
Mar 2014	-$27.37M	-42.0%
Dec 2013	-$19.28M	+22.6%
Sep 2013	-$24.92M	-263.6%
Jun 2013	-$6.85M	-353.3%
Mar 2013	$2.71M	+114.1%

Month	Value	Change
Dec 2012	-$19.14M	+27.0%
Sep 2012	-$26.20M	-599.7%
Jun 2012	$5.24M	+128.4%
Mar 2012	-$18.46M	-38.2%
Dec 2011	-$13.35M	+24.8%
Sep 2011	-$17.76M	-82.9%
Jun 2011	-$9.71M	+9.3%
Mar 2011	-$10.70M	+37.9%
Mar 2001	-$17.23M	-72.1%
Dec 2000	-$10.01M	-4,960.2%
Sep 2000	$206.00K	+102.5%
Jun 2000	-$8.18M	+25.7%
Mar 2000	-$11.01M	+11.9%
Dec 1999	-$12.50M	-54.3%
Sep 1999	-$8.10M	+32.5%
Jun 1999	-$12.00M	-14.3%
Mar 1999	-$10.50M	-8.2%
Dec 1998	-$9.70M	-981.8%
Sep 1998	$1.10M	+108.5%
Jun 1998	-$13.00M	-18.2%
Mar 1998	-$11.00M	-6.8%
Dec 1997	-$10.30M	-296.2%
Sep 1997	-$2.60M	+73.2%
Jun 1997	-$9.70M	-9.0%
Mar 1997	-$8.90M	+6.3%
Dec 1996	-$9.50M	-41.8%
Sep 1996	-$6.70M	+17.3%
Jun 1996	-$8.10M	-68.8%
Mar 1996	-$4.80M	+22.6%
Dec 1995	-$6.20M	+16.2%
Sep 1995	-$7.40M	-23.3%
Jun 1995	-$6.00M	+1.6%
Mar 1995	-$6.10M	+45.5%
Dec 1994	-$11.20M	-124.0%
Sep 1994	-$5.00M	-4.2%
Jun 1994	-$4.80M	-6.7%
Mar 1994	-$4.50M	-2.3%
Dec 1993	-$4.40M	0.0%
Sep 1993	-$4.40M	+4.3%
Jun 1993	-$4.60M	+9.8%
Mar 1993	-$5.10M	+25.0%
Dec 1992	-$6.80M	-58.1%
Sep 1992	-$4.30M	-16.2%
Jun 1992	-$3.70M	+21.3%
Mar 1992	-$4.70M	+2.1%
Dec 1991	-$4.80M	-140.0%
Sep 1991	-$2.00M	+4.8%
Jun 1991	-$2.10M	-75.0%
Mar 1991	-$1.20M	+80.0%
Dec 1990	-$6.00M	-1,300.0%
Sep 1990	$500.00K	0.0%
Jun 1990	$500.00K	0.0%
Mar 1990	$500.00K	-

FAQ

What is the current quarterly EBITDA of IONS?: As of today, IONS quarterly EBITDA is -$94.66M
What is IONS quarterly EBITDA most recent change?: IONS quarterly EBITDA was up +13.93% on June 30, 2026
What is 1-year change in IONS quarterly EBITDA?: IONS quarterly EBITDA is down -165.16% year-over-year
How far is IONS quarterly EBITDA from its all-time high?: IONS quarterly EBITDA is currently -135.76% below its historical high of $264.73M set on December 31, 2019
How does IONS quarterly EBITDA rank versus sector peers?: IONS quarterly EBITDA is higher than 3.43% of companies in Healthcare sector
When is IONS next earnings release?: The next earnings release for IONS is on November 4, 2026

EBITDA Formula

EBITDA = Net Income + + +

TTM EBITDA

-$567.97M$239.93M-73.14%

June 30, 2026

Summary

Current Value: As of today, IONS TTM EBITDA is -$567.97M, down -73.14% on June 30, 2026
Historical Performance: IONS TTM EBITDA is down -132.69% year-over-year, down -26.76% over the past 3 years
All-Time High Comparison: IONS TTM EBITDA is currently -249.13% below its historical high of $380.84M set on December 31, 2019
3-Year Low Comparison: IONS TTM EBITDA is at its 3-year low
Sector Comparison: IONS TTM EBITDA is higher than 0.95% of companies in Healthcare sector

Performance

IONS Performance
Metric	Date	Value	3M	1Y	3Y	5Y
TTM EBITDA	Jun 30, 26	-$567.97M	-73.1%	-132.7%	-26.8%	-176.3%
Annual EBITDA	Dec 31, 25	-$358.99M	–	+20.8%	+7.5%	-131.7%
Quarterly EBITDA	Jun 30, 26	-$94.66M	+13.9%	-165.2%	-12.0%	-39.3%
Price	Aug 7, 26	$56.56	-25.3%	+35.8%	+42.0%	+45.6%
PE Ratio	Aug 7, 26	-	–	–	–	–
TTM Revenue	Jun 30, 26	$873.76M	-17.4%	-7.5%	+38.5%	+27.1%
TTM EPS	Jun 30, 26	-$3.47	-65.2%	-87.5%	-60.5%	+11.5%
	Jun 30, 26	-$594.61M	-68.5%	-123.8%	-26.1%	-164.9%
TTM Net Income	Jun 30, 26	-$564.78M	-72.9%	-110.8%	-83.0%	-0.3%

TTM EBITDA Highs

IONS TTM EBITDA Highs Comparison
Period	High	Date	Current
1Y	-$244.09M	N/A	-132.7%
3Y	-$244.09M	Jun 30, 25	-132.7%
5Y	$38.89M	Sep 30, 22	-1560.5%
All	$380.84M	Dec 31, 19	-249.1%

TTM EBITDA Lows

IONS TTM EBITDA Lows Comparison
Period	Low	Date	Current
1Y	-$567.97M	Jun 30, 26	at low
3Y	-$567.97M	Jun 30, 26	at low
5Y	-$567.97M	Jun 30, 26	at low
All	-$567.97M	Jun 30, 26	at low

TTM EBITDA History

Month	Value	Change
Jun 2026	-$567.97M	-73.1%
Mar 2026	-$328.05M	+8.8%
Dec 2025	-$359.53M	-40.1%
Sep 2025	-$256.61M	-5.1%
Jun 2025	-$244.09M	+45.7%
Mar 2025	-$449.87M	+0.5%
Dec 2024	-$452.27M	-30.0%
Sep 2024	-$347.93M	-1.6%
Jun 2024	-$342.44M	+6.5%
Mar 2024	-$366.43M	-10.7%
Dec 2023	-$331.11M	+37.7%
Sep 2023	-$531.69M	-18.7%
Jun 2023	-$448.08M	-0.9%
Mar 2023	-$444.00M	-14.4%
Dec 2022	-$388.07M	-1,097.9%
Sep 2022	$38.89M	+229.4%
Jun 2022	$11.81M	-51.4%
Mar 2022	$24.28M	+337.3%
Dec 2021	-$10.23M	+96.0%
Sep 2021	-$254.65M	-23.9%
Jun 2021	-$205.59M	-10.9%
Mar 2021	-$185.36M	-19.4%
Dec 2020	-$155.26M	-221.4%
Sep 2020	$127.91M	-23.0%
Jun 2020	$166.20M	-16.4%
Mar 2020	$198.75M	-47.8%
Dec 2019	$380.84M	+192.0%
Sep 2019	$130.42M	+19.8%
Jun 2019	$108.89M	+41.9%
Mar 2019	$76.73M	+257.1%
Dec 2018	-$48.84M	+28.5%
Sep 2018	-$68.35M	-74.5%
Jun 2018	-$39.16M	-329.8%
Mar 2018	$17.04M	-56.7%
Dec 2017	$39.40M	-55.2%
Sep 2017	$88.03M	-5.6%
Jun 2017	$93.23M	+146.6%
Mar 2017	$37.81M	+204.8%
Dec 2016	-$36.08M	+74.2%
Sep 2016	-$139.82M	+31.6%
Jun 2016	-$204.42M	-84.9%
Mar 2016	-$110.58M	-68.8%
Dec 2015	-$65.52M	-1,006.9%
Sep 2015	$7.23M	-78.5%
Jun 2015	$33.67M	+287.8%
Mar 2015	-$17.93M	+53.2%
Dec 2014	-$38.33M	+45.3%
Sep 2014	-$70.05M	+7.7%
Jun 2014	-$75.89M	+3.2%
Mar 2014	-$78.42M	-62.2%
Dec 2013	-$48.34M	-0.3%
Sep 2013	-$48.20M	+2.6%
Jun 2013	-$49.49M	-32.3%
Mar 2013	-$37.39M	+36.1%

Month	Value	Change
Dec 2012	-$58.55M	-11.0%
Sep 2012	-$52.77M	-19.1%
Jun 2012	-$44.32M	+25.2%
Mar 2012	-$59.27M	-15.1%
Dec 2011	-$51.52M	-35.0%
Sep 2011	-$38.17M	-87.0%
Jun 2011	-$20.41M	-90.7%
Mar 2011	-$10.70M	+69.6%
Mar 2001	-$35.22M	-21.5%
Dec 2000	-$28.99M	+7.9%
Sep 2000	-$31.48M	+20.9%
Jun 2000	-$39.78M	+8.8%
Mar 2000	-$43.61M	-1.2%
Dec 1999	-$43.10M	-6.9%
Sep 1999	-$40.30M	-29.6%
Jun 1999	-$31.10M	+3.1%
Mar 1999	-$32.10M	+1.5%
Dec 1998	-$32.60M	+1.8%
Sep 1998	-$33.20M	+10.0%
Jun 1998	-$36.90M	-9.8%
Mar 1998	-$33.60M	-6.7%
Dec 1997	-$31.50M	-2.6%
Sep 1997	-$30.70M	+11.8%
Jun 1997	-$34.80M	-4.8%
Mar 1997	-$33.20M	-14.1%
Dec 1996	-$29.10M	-12.8%
Sep 1996	-$25.80M	+2.6%
Jun 1996	-$26.50M	-8.6%
Mar 1996	-$24.40M	+5.1%
Dec 1995	-$25.70M	+16.3%
Sep 1995	-$30.70M	-8.5%
Jun 1995	-$28.30M	-4.4%
Mar 1995	-$27.10M	-6.3%
Dec 1994	-$25.50M	-36.4%
Sep 1994	-$18.70M	-3.3%
Jun 1994	-$18.10M	-1.1%
Mar 1994	-$17.90M	+3.2%
Dec 1993	-$18.50M	+11.5%
Sep 1993	-$20.90M	-0.5%
Jun 1993	-$20.80M	-4.5%
Mar 1993	-$19.90M	-2.1%
Dec 1992	-$19.50M	-11.4%
Sep 1992	-$17.50M	-15.1%
Jun 1992	-$15.20M	-11.8%
Mar 1992	-$13.60M	-34.7%
Dec 1991	-$10.10M	+10.6%
Sep 1991	-$11.30M	-28.4%
Jun 1991	-$8.80M	-41.9%
Mar 1991	-$6.20M	-37.8%
Dec 1990	-$4.50M	-400.0%
Sep 1990	$1.50M	+50.0%
Jun 1990	$1.00M	+100.0%
Mar 1990	$500.00K	-

FAQ

What is the current TTM EBITDA of IONS?: As of today, IONS TTM EBITDA is -$567.97M
What is IONS TTM EBITDA most recent change?: IONS TTM EBITDA was down -73.14% on June 30, 2026
What is 1-year change in IONS TTM EBITDA?: IONS TTM EBITDA is down -132.69% year-over-year
How far is IONS TTM EBITDA from its all-time high?: IONS TTM EBITDA is currently -249.13% below its historical high of $380.84M set on December 31, 2019
How does IONS TTM EBITDA rank versus sector peers?: IONS TTM EBITDA is higher than 0.95% of companies in Healthcare sector
When is IONS next earnings release?: The next earnings release for IONS is on November 4, 2026

EBITDA Formula

EBITDA = Net Income + + +

Data Sources & References

IONS Official Website www.ionis.com
Most Recent Annual Report (10-K) www.sec.gov/Archives/edgar/data/874015/000087401526000115/0000874015-26-000115-index.htm
IONS Profile on Yahoo Finance finance.yahoo.com/quote/IONS
IONS Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/ions