What is the current annual debt to equity of IONS?

As of today, IONS annual debt to equity is 5.24

What is 1-year change in IONS annual debt to equity?

IONS annual debt to equity is up +57.36% year-over-year

What is 3-year change in IONS annual debt to equity?

IONS annual debt to equity is up +119.25% over the past 3 years

How far is IONS annual debt to equity from its all-time high?

IONS annual debt to equity is currently -97.31% below its historical high of 195.07 set on December 31, 2007

How does IONS annual debt to equity rank versus sector peers?

IONS annual debt to equity is higher than 97.28% of companies in Healthcare sector

When is IONS next annual earnings release?

As of today, the next annual earnings release for IONS has not been scheduled

What is the current quarterly debt to equity of IONS?

As of today, IONS quarterly debt to equity is 4.98

What is IONS quarterly debt to equity most recent change?

IONS quarterly debt to equity was down -6.21% on June 30, 2026

What is 1-year change in IONS quarterly debt to equity?

IONS quarterly debt to equity is up +59.11% year-over-year

How far is IONS quarterly debt to equity from its all-time high?

IONS quarterly debt to equity is currently -99.33% below its historical high of 742.15 set on September 30, 2007

How does IONS quarterly debt to equity rank versus sector peers?

IONS quarterly debt to equity is higher than 96.13% of companies in Healthcare sector

When is IONS next earnings release?

The next earnings release for IONS is on November 4, 2026

IONS Debt To Equity Ratio History & Chart Since 1990

Annual Debt To Equity

5.241.91+57.36%

December 31, 2025

Summary

Current Value: As of today, IONS annual debt to equity is 5.24, up +57.36% on December 31, 2025
Historical Performance: IONS annual debt to equity is up +119.25% over the past 3 years, up +315.87% over the past 5 years
All-Time High Comparison: IONS annual debt to equity is currently -97.31% below its historical high of 195.07 set on December 31, 2007
3-Year Low Comparison: IONS annual debt to equity is +119.25% above its 3-year low of 2.39 reached on an earlier date
Sector Comparison: IONS annual debt to equity is higher than 97.28% of companies in Healthcare sector

Debt To Equity Chart

Performance

IONS Performance
Metric	Date	Value	1Y	3Y	5Y	15Y
Annual Debt To Equity	Dec 31, 25	5.24	+57.4%	+119.3%	+315.9%	+788.1%
Quarterly Debt To Equity	Jun 30, 26	4.98	+59.1%	+6.2%	+121.3%	+413.4%
Price	Aug 10, 26	$56.94	+36.7%	+43.0%	+46.6%	+758.8%
Annual Total Debt	Dec 31, 25	$2.61B	+33.5%	+90.9%	+178.2%	+1712.2%
	Dec 31, 25	$489.09M	-16.9%	-14.6%	-34.2%	+100.0%
	Dec 31, 25	1.95	-77.0%	-72.4%	-45.2%	-57.2%
	Dec 31, 25	1.94	-77.0%	-72.3%	-44.9%	-57.3%
	Dec 31, 25	$1.18B	+10000.0%	+10000.0%	+274.2%	+10000.0%
	Dec 31, 25	$1.38B	-29.2%	+1.4%	+121.5%	+896.3%
	Jun 30, 26	2	-50.0%	0.0%	+100.0%	+100.0%
	Aug 10, 26	1.23	0.0%	-20.6%	-43.3%	+1018.2%

Debt To Equity Highs

IONS Annual Debt To Equity Highs Comparison
Period	High	Date	Current
3Y	5.24	Dec 31, 25	at high
5Y	5.24	Dec 31, 25	at high
All	195.07	Dec 31, 07	-97.3%

Debt To Equity Lows

IONS Annual Debt To Equity Lows Comparison
Period	Low	Date	Current
3Y	2.39	N/A	+119.3%
5Y	1.26	N/A	+315.9%
All	-19.42	Dec 31, 98	+127.0%

Debt To Equity History

Year	Value	Change
2025	5.24	+57.4%
2024	3.33	-34.6%
2023	5.09	+113.0%
2022	2.39	+47.5%
2021	1.62	+28.6%
2020	1.26	+133.3%
2019	0.54	-12.9%
2018	0.62	-71.3%
2017	2.16	-63.5%
2016	5.92	+150.8%
2015	2.36	+32.6%
2014	1.78	+191.8%
2013	0.61	-50.8%
2012	1.24	+42.5%
2011	0.87	+47.5%
2010	0.59	+22.9%
2009	0.48	-81.5%
2008	2.60	-98.7%

Year	Value	Change
2007	195.07	+9,415.6%
2006	2.05	-96.3%
2005	55.44	+1,716.3%
2004	-3.43	-200.3%
2003	3.42	+147.8%
2002	1.38	+126.2%
2001	0.61	-62.1%
2000	1.61	-98.5%
1999	104.89	+640.1%
1998	-19.42	-1,256.0%
1997	1.68	+273.3%
1996	0.45	+246.2%
1995	0.13	-48.0%
1994	0.25	+4.2%
1993	0.24	+9.1%
1992	0.22	+120.0%
1991	0.10	-85.9%
1990	0.71	-

FAQ

What is the current annual debt to equity of IONS?: As of today, IONS annual debt to equity is 5.24
What is 1-year change in IONS annual debt to equity?: IONS annual debt to equity is up +57.36% year-over-year
What is 3-year change in IONS annual debt to equity?: IONS annual debt to equity is up +119.25% over the past 3 years
How far is IONS annual debt to equity from its all-time high?: IONS annual debt to equity is currently -97.31% below its historical high of 195.07 set on December 31, 2007
How does IONS annual debt to equity rank versus sector peers?: IONS annual debt to equity is higher than 97.28% of companies in Healthcare sector
When is IONS next annual earnings release?: As of today, the next annual earnings release for IONS has not been scheduled

Debt To Equity Formula

Debt To Equity =

Total Debt

Quarterly Debt To Equity

4.980.33-6.21%

June 30, 2026

Summary

Current Value: As of today, IONS quarterly debt to equity is 4.98, down -6.21% on June 30, 2026
Historical Performance: IONS quarterly debt to equity is up +59.11% year-over-year, up +6.18% over the past 3 years
All-Time High Comparison: IONS quarterly debt to equity is currently -99.33% below its historical high of 742.15 set on September 30, 2007
3-Year Low Comparison: IONS quarterly debt to equity is +66.00% above its 3-year low of 3.00 reached on September 30, 2024
Sector Comparison: IONS quarterly debt to equity is higher than 96.13% of companies in Healthcare sector

Performance

IONS Performance
Metric	Date	Value	3M	1Y	3Y	5Y
Quarterly Debt To Equity	Jun 30, 26	4.98	-6.2%	+59.1%	+6.2%	+121.3%
Annual Debt To Equity	Dec 31, 25	5.24	–	+57.4%	+119.3%	+315.9%
Price	Aug 10, 26	$56.94	-24.8%	+36.7%	+43.0%	+46.6%
Quarterly Total Debt	Jun 30, 26	$2.19B	-16.1%	+10.8%	+8.9%	+67.0%
	Jun 30, 26	$439.74M	-10.5%	-30.4%	+2.7%	-24.5%
	Jun 30, 26	7.89	+92.4%	+174.9%	-13.2%	+3.5%
	Jun 30, 26	7.73	+89.0%	+170.3%	-14.1%	+2.5%
	Jun 30, 26	$12.92M	-97.1%	-98.0%	+45.2%	-81.5%
	Jun 30, 26	$2.18B	+0.5%	+63.5%	+8.8%	+75.4%
	Jun 30, 26	2	0.0%	-50.0%	0.0%	+100.0%
	Aug 10, 26	1.23	-32.8%	0.0%	-20.6%	-43.3%

Quarterly Debt To Equity Highs

IONS Quarterly Debt To Equity Highs Comparison
Period	High	Date	Current
1Y	5.35	Dec 31, 25	-6.9%
3Y	7.50	Jun 30, 24	-33.6%
5Y	7.50	Jun 30, 24	-33.6%
All	742.15	Sep 30, 07	-99.3%

Quarterly Debt To Equity Lows

IONS Quarterly Debt To Equity Lows Comparison
Period	Low	Date	Current
1Y	3.13	N/A	+59.1%
3Y	3.00	Sep 30, 24	+66.0%
5Y	1.62	Dec 31, 21	+207.4%
All	-19.42	Dec 31, 98	+125.6%

Quarterly Debt To Equity History

Month	Value	Change
Jun 2026	4.98	-6.2%
Mar 2026	5.31	-0.7%
Dec 2025	5.35	+61.1%
Sep 2025	3.32	+6.1%
Jun 2025	3.13	-24.0%
Mar 2025	4.12	+23.7%
Dec 2024	3.33	+11.0%
Sep 2024	3.00	-60.0%
Jun 2024	7.50	+13.0%
Mar 2024	6.64	+30.5%
Dec 2023	5.09	-18.7%
Sep 2023	6.26	+33.5%
Jun 2023	4.69	+21.8%
Mar 2023	3.85	+61.1%
Dec 2022	2.39	+13.3%
Sep 2022	2.11	+5.0%
Jun 2022	2.01	+14.2%
Mar 2022	1.76	+8.6%
Dec 2021	1.62	-34.1%
Sep 2021	2.46	+9.3%
Jun 2021	2.25	+63.0%
Mar 2021	1.38	+9.5%
Dec 2020	1.26	+113.6%
Sep 2020	0.59	0.0%
Jun 2020	0.59	0.0%
Mar 2020	0.59	+9.3%
Dec 2019	0.54	+8.0%
Sep 2019	0.50	-5.7%
Jun 2019	0.53	-3.6%
Mar 2019	0.55	-11.3%
Dec 2018	0.62	-31.1%
Sep 2018	0.90	0.0%
Jun 2018	0.90	-55.9%
Mar 2018	2.04	-5.6%
Dec 2017	2.16	+11.3%
Sep 2017	1.94	-30.7%
Jun 2017	2.80	-5.1%
Mar 2017	2.95	-50.2%
Dec 2016	5.92	+66.8%
Sep 2016	3.55	-18.6%
Jun 2016	4.36	+43.9%
Mar 2016	3.03	+26.3%
Dec 2015	2.40	+25.0%
Sep 2015	1.92	+23.9%
Jun 2015	1.55	-7.7%
Mar 2015	1.68	-5.6%
Dec 2014	1.78	+161.8%
Sep 2014	0.68	+6.3%
Jun 2014	0.64	+3.2%
Mar 2014	0.62	+1.6%
Dec 2013	0.61	+5.2%
Sep 2013	0.58	+1.8%
Jun 2013	0.57	-49.6%
Mar 2013	1.13	-8.9%
Dec 2012	1.24	-6.8%
Sep 2012	1.33	-11.3%
Jun 2012	1.50	+50.0%
Mar 2012	1.00	+14.9%
Dec 2011	0.87	-25.0%
Sep 2011	1.16	+19.6%
Jun 2011	0.97	+42.6%
Mar 2011	0.68	+15.3%
Dec 2010	0.59	0.0%
Sep 2010	0.59	+3.5%
Jun 2010	0.57	+11.8%
Mar 2010	0.51	+6.3%
Dec 2009	0.48	0.0%
Sep 2009	0.48	+4.3%
Jun 2009	0.46	0.0%
Mar 2009	0.46	-82.3%
Dec 2008	2.60	+5.3%
Sep 2008	2.47	-15.1%

Month	Value	Change
Jun 2008	2.91	-5.5%
Mar 2008	3.08	-98.4%
Dec 2007	195.07	-73.7%
Sep 2007	742.15	>+9,900.0%
Jun 2007	3.68	-18.4%
Mar 2007	4.51	+120.0%
Dec 2006	2.05	-97.7%
Sep 2006	90.31	+321.2%
Jun 2006	21.44	+219.8%
Mar 2006	-17.89	-132.3%
Dec 2005	55.44	+49.2%
Sep 2005	37.17	+1,922.1%
Jun 2005	-2.04	+16.0%
Mar 2005	-2.43	+29.2%
Dec 2004	-3.43	+74.7%
Sep 2004	-13.57	-167.2%
Jun 2004	20.18	+317.8%
Mar 2004	4.83	+41.2%
Dec 2003	3.42	+48.1%
Sep 2003	2.31	+23.5%
Jun 2003	1.87	+14.0%
Mar 2003	1.64	+18.8%
Dec 2002	1.38	+24.3%
Sep 2002	1.11	+2.8%
Jun 2002	1.08	+52.1%
Mar 2002	0.71	+16.4%
Dec 2001	0.61	-45.0%
Sep 2001	1.11	-60.4%
Jun 2001	2.80	+14.3%
Mar 2001	2.45	+52.2%
Dec 2000	1.61	+6.6%
Sep 2000	1.51	+7.1%
Jun 2000	1.41	-29.1%
Mar 2000	1.99	-98.1%
Dec 1999	104.89	+1,188.1%
Sep 1999	-9.64	+41.5%
Jun 1999	-16.49	-213.5%
Mar 1999	-5.26	+72.9%
Dec 1998	-19.42	-402.0%
Sep 1998	6.43	+10.3%
Jun 1998	5.83	+143.9%
Mar 1998	2.39	+42.3%
Dec 1997	1.68	+95.3%
Sep 1997	0.86	+2.4%
Jun 1997	0.84	+64.7%
Mar 1997	0.51	+13.3%
Dec 1996	0.45	+164.7%
Sep 1996	0.17	+13.3%
Jun 1996	0.15	0.0%
Mar 1996	0.15	+15.4%
Dec 1995	0.13	-27.8%
Sep 1995	0.18	-33.3%
Jun 1995	0.27	0.0%
Mar 1995	0.27	+8.0%
Dec 1994	0.25	+4.2%
Sep 1994	0.24	+14.3%
Jun 1994	0.21	+5.0%
Mar 1994	0.20	-13.0%
Dec 1993	0.23	-8.0%
Sep 1993	0.25	+25.0%
Jun 1993	0.20	+17.6%
Mar 1993	0.17	-46.9%
Dec 1992	0.32	+10.3%
Sep 1992	0.29	+20.8%
Jun 1992	0.24	+20.0%
Mar 1992	0.20	+100.0%
Dec 1991	0.10	-52.4%
Sep 1991	0.21	+16.7%
Jun 1991	0.18	+63.6%
Mar 1991	0.11	-84.5%
Dec 1990	0.71	-

FAQ

What is the current quarterly debt to equity of IONS?: As of today, IONS quarterly debt to equity is 4.98
What is IONS quarterly debt to equity most recent change?: IONS quarterly debt to equity was down -6.21% on June 30, 2026
What is 1-year change in IONS quarterly debt to equity?: IONS quarterly debt to equity is up +59.11% year-over-year
How far is IONS quarterly debt to equity from its all-time high?: IONS quarterly debt to equity is currently -99.33% below its historical high of 742.15 set on September 30, 2007
How does IONS quarterly debt to equity rank versus sector peers?: IONS quarterly debt to equity is higher than 96.13% of companies in Healthcare sector
When is IONS next earnings release?: The next earnings release for IONS is on November 4, 2026

Debt To Equity Formula

Debt To Equity =

Total Debt

Data Sources & References

IONS Official Website www.ionis.com
Most Recent Annual Report (10-K) www.sec.gov/Archives/edgar/data/874015/000087401526000115/0000874015-26-000115-index.htm
IONS Profile on Yahoo Finance finance.yahoo.com/quote/IONS
IONS Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/ions