What is the current annual gross margin of PFE?

As of today, PFE annual gross margin is 74.33%

What is 1-year change in PFE annual gross margin?

PFE annual gross margin is up +13.02% year-over-year

What is 3-year change in PFE annual gross margin?

PFE annual gross margin is up +20.10% over the past 3 years

How far is PFE annual gross margin from its all-time high?

PFE annual gross margin is currently -15.06% below its historical high of 87.51% set on December 31, 2002

How does PFE annual gross margin rank versus sector peers?

PFE annual gross margin is higher than 72.73% of companies in Healthcare sector

When is PFE next annual earnings release?

As of today, the next annual earnings release for PFE has not been scheduled

What is the current quarterly gross margin of PFE?

As of today, PFE quarterly gross margin is 69.97%

What is PFE quarterly gross margin most recent change?

PFE quarterly gross margin was up +4.20% on December 31, 2025

What is 1-year change in PFE quarterly gross margin?

PFE quarterly gross margin is down -4.16% year-over-year

How far is PFE quarterly gross margin from its all-time high?

PFE quarterly gross margin is currently -27.48% below its historical high of 96.49% set on December 31, 2002

How does PFE quarterly gross margin rank versus sector peers?

PFE quarterly gross margin is higher than 68.67% of companies in Healthcare sector

When is PFE next earnings release?

The next earnings release for PFE is on April 28, 2026

Pfizer Inc. (PFE) Gross Margin History & Chart Since 1980

Annual Gross Margin

74.33%8.56%+13.02%

December 31, 2025

Summary

Current Value: As of today, PFE annual gross margin is 74.33%, up +13.02% on December 31, 2025
Historical Performance: PFE annual gross margin is up +20.10% over the past 3 years, and up +3.61% over the past 5 years
All-Time High Comparison: PFE annual gross margin is currently -15.06% below its historical high of 87.51% set on December 31, 2002
3-Year Low Comparison: PFE annual gross margin is +45.89% above its 3-year low of 50.95% reached on December 31, 2023
Sector Comparison: PFE annual gross margin is higher than 72.73% of companies in Healthcare sector

Gross Margin Chart

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Performance

PFE Performance
Metric	Date	Value	1Y	3Y	5Y	15Y
Annual Gross Margin	Dec 31, 25	74.33%	+13.0%	+20.1%	+3.6%	+7.5%
Quarterly Gross Margin	Dec 31, 25	69.97%	-4.2%	+26.9%	+2.5%	+2.3%
Price	Feb 5, 26	$26.49	+2.6%	-39.5%	-24.1%	+44.7%
PE Ratio	Feb 5, 26	19.55	+6.5%	+144.7%	-8.8%	+10.0%
Annual Revenue	Dec 31, 25	$62.58B	-1.6%	-37.6%	+50.3%	-6.7%
Annual Gross Profit	Dec 31, 25	$46.51B	+11.2%	-25.1%	+55.7%	+0.4%
Annual Operating Margin	Dec 31, 25	27.82%	+7.4%	-25.7%	+27.6%	+5.2%
Annual Net Margin	Dec 31, 25	12.44%	-1.7%	-60.3%	-22.3%	+1.6%

Gross Margin Highs

PFE Annual Gross Margin Highs Comparison
Period	High	Date	Current
3Y	74.33%	Dec 31, 25	at high
5Y	74.33%	Dec 31, 25	at high
All	87.51%	Dec 31, 02	-15.1%

Gross Margin Lows

PFE Annual Gross Margin Lows Comparison
Period	Low	Date	Current
3Y	50.95%	Dec 31, 23	+45.9%
5Y	50.95%	Dec 31, 23	+45.9%
All	50.95%	Dec 31, 23	+45.9%

Gross Margin History

Year	Value	Change
2025	74.33%	+13.0%
2024	65.77%	+29.1%
2023	50.95%	-17.7%
2022	61.89%	+7.3%
2021	57.67%	-19.6%
2020	71.74%	+3.5%
2019	69.34%	-1.2%
2018	70.16%	+0.3%
2017	69.97%	+0.2%
2016	69.80%	-4.5%
2015	73.07%	-0.1%
2014	73.17%	+0.3%
2013	72.95%	-0.4%
2012	73.21%	+1.9%
2011	71.88%	+4.0%
2010	69.11%	-10.0%
2009	76.82%	-3.0%
2008	79.22%	+4.5%
2007	75.79%	-3.2%
2006	78.27%	+0.6%
2005	77.84%	-1.8%
2004	79.23%	-0.5%
2003	79.65%	-9.0%

Year	Value	Change
2002	87.51%	+4.2%
2001	83.99%	+1.8%
2000	82.53%	-1.9%
1999	84.15%	-0.5%
1998	84.56%	+4.0%
1997	81.30%	+1.4%
1996	80.19%	+2.8%
1995	78.01%	+1.5%
1994	76.83%	+0.7%
1993	76.30%	+6.0%
1992	72.00%	+5.4%
1991	68.34%	+5.6%
1990	64.73%	+1.7%
1989	63.64%	+1.8%
1988	62.49%	+1.7%
1987	61.44%	-0.2%
1986	61.56%	-0.0%
1985	61.59%	+1.9%
1984	60.47%	+2.8%
1983	58.84%	+5.8%
1982	55.63%	+6.4%
1981	52.27%	+0.2%
1980	52.17%	-

FAQ

What is the current annual gross margin of PFE?
As of today, PFE annual gross margin is 74.33%
What is 1-year change in PFE annual gross margin?
PFE annual gross margin is up +13.02% year-over-year
What is 3-year change in PFE annual gross margin?
PFE annual gross margin is up +20.10% over the past 3 years
How far is PFE annual gross margin from its all-time high?
PFE annual gross margin is currently -15.06% below its historical high of 87.51% set on December 31, 2002
How does PFE annual gross margin rank versus sector peers?
PFE annual gross margin is higher than 72.73% of companies in Healthcare sector
When is PFE next annual earnings release?
As of today, the next annual earnings release for PFE has not been scheduled

Quarterly Gross Margin

69.97%2.82%+4.20%

December 31, 2025

Summary

Current Value: As of today, PFE quarterly gross margin is 69.97%, up +4.20% on December 31, 2025
Historical Performance: PFE quarterly gross margin is down -4.16% year-over-year, and up +26.92% over the past 3 years
All-Time High Comparison: PFE quarterly gross margin is currently -27.48% below its historical high of 96.49% set on December 31, 2002
3-Year Low Comparison: PFE quarterly gross margin is +226.81% above its 3-year low of 21.41% reached on September 30, 2023
Sector Comparison: PFE quarterly gross margin is higher than 68.67% of companies in Healthcare sector

Performance

PFE Performance
Metric	Date	Value	3M	1Y	3Y	5Y
Quarterly Gross Margin	Dec 31, 25	69.97%	+4.2%	-4.2%	+26.9%	+2.5%
Annual Gross Margin	Dec 31, 25	74.33%	–	+13.0%	+20.1%	+3.6%
Price	Feb 5, 26	$26.49	+6.6%	+2.6%	-39.5%	-24.1%
PE Ratio	Feb 5, 26	19.55	+35.0%	+6.5%	+144.7%	-8.8%
Quarterly Revenue	Dec 31, 25	$17.56B	+5.4%	-1.2%	-27.7%	+50.9%
Quarterly Gross Profit	Dec 31, 25	$12.29B	+9.8%	-5.3%	-8.3%	+54.7%
Quarterly Operating Margin	Dec 31, 25	21.01%	-36.7%	-34.8%	-4.6%	+165.3%
Quarterly Net Margin	Dec 31, 25	-9.34%	-143.8%	-504.3%	-145.4%	-271.4%

Quarterly Gross Margin Highs

PFE Quarterly Gross Margin Highs Comparison
Period	High	Date	Current
1Y	73.01%	N/A	-4.2%
3Y	73.01%	Dec 31, 24	-4.2%
5Y	73.01%	Dec 31, 24	-4.2%
All	96.49%	Dec 31, 02	-27.5%

Quarterly Gross Margin Lows

PFE Quarterly Gross Margin Lows Comparison
Period	Low	Date	Current
1Y	64.29%	Jun 29, 25	+8.8%
3Y	21.41%	Sep 30, 23	+226.8%
5Y	21.41%	Sep 30, 23	+226.8%
All	21.41%	Sep 30, 23	+226.8%

Quarterly Gross Margin History

Month	Value	Change
Dec 2025	69.97%	+4.2%
Sep 2025	67.15%	+4.4%
Jun 2025	64.29%	-10.3%
Mar 2025	71.65%	-1.9%
Dec 2024	73.01%	+20.0%
Sep 2024	60.85%	-1.9%
Jun 2024	62.06%	-12.0%
Mar 2024	70.56%	+71.9%
Dec 2023	41.04%	+91.7%
Sep 2023	21.41%	-66.9%
Jun 2023	64.67%	-4.6%
Mar 2023	67.81%	+23.0%
Dec 2022	55.13%	-20.3%
Sep 2022	69.13%	+2.7%
Jun 2022	67.32%	+16.2%
Mar 2022	57.92%	+4.9%
Dec 2021	55.21%	+0.7%
Sep 2021	54.84%	-6.2%
Jun 2021	58.49%	-10.8%
Mar 2021	65.57%	-4.0%
Dec 2020	68.27%	-5.5%
Sep 2020	72.21%	-0.8%
Jun 2020	72.81%	+0.5%
Mar 2020	72.47%	+1.4%
Dec 2019	71.50%	+2.0%
Sep 2019	70.08%	-2.4%
Jun 2019	71.83%	-1.1%
Mar 2019	72.60%	+4.8%
Dec 2018	69.27%	-1.7%
Sep 2018	70.48%	+1.2%
Jun 2018	69.65%	-2.1%
Mar 2018	71.13%	+4.6%
Dec 2017	68.00%	-2.8%
Sep 2017	69.93%	-0.5%
Jun 2017	70.29%	-1.9%
Mar 2017	71.62%	+3.3%
Dec 2016	69.33%	-0.4%
Sep 2016	69.64%	+0.6%
Jun 2016	69.23%	-2.5%
Mar 2016	71.02%	+2.4%
Dec 2015	69.37%	-6.6%
Sep 2015	74.27%	-0.6%
Jun 2015	74.72%	+0.0%
Mar 2015	74.71%	+2.9%
Dec 2014	72.60%	-1.3%
Sep 2014	73.59%	-0.0%
Jun 2014	73.62%	+1.1%
Mar 2014	72.85%	+1.7%
Dec 2013	71.63%	-2.6%
Sep 2013	73.54%	-1.2%
Jun 2013	74.42%	+4.1%
Mar 2013	71.50%	+0.5%
Dec 2012	71.15%	-2.3%
Sep 2012	72.84%	-1.0%
Jun 2012	73.55%	+2.2%
Mar 2012	71.99%	+2.0%
Dec 2011	70.57%	-0.4%
Sep 2011	70.87%	+0.7%
Jun 2011	70.39%	+0.1%
Mar 2011	70.32%	+2.9%
Dec 2010	68.37%	-2.7%
Sep 2010	70.25%	-0.5%
Jun 2010	70.63%	+7.1%
Mar 2010	65.96%	-5.2%
Dec 2009	69.61%	-12.6%
Sep 2009	79.69%	+0.7%
Jun 2009	79.12%	-4.0%
Mar 2009	82.42%	-0.7%
Dec 2008	83.03%	+5.7%
Sep 2008	78.53%	+1.5%
Jun 2008	77.39%	-0.6%
Mar 2008	77.83%	+2.5%

Month	Value	Change
Dec 2007	75.95%	+34.5%
Sep 2007	56.47%	-25.1%
Jun 2007	75.44%	-4.6%
Mar 2007	79.09%	+2.9%
Dec 2006	76.85%	-1.4%
Sep 2006	77.93%	-0.9%
Jun 2006	78.63%	-0.2%
Mar 2006	78.75%	+1.8%
Dec 2005	77.39%	-0.9%
Sep 2005	78.10%	+2.3%
Jun 2005	76.35%	-0.8%
Mar 2005	76.95%	-8.9%
Dec 2004	84.48%	+4.7%
Sep 2004	80.65%	+1.9%
Jun 2004	79.13%	+0.3%
Mar 2004	78.88%	+3.5%
Dec 2003	76.19%	+10.2%
Sep 2003	69.12%	-13.3%
Jun 2003	79.72%	-8.9%
Mar 2003	87.51%	-9.3%
Dec 2002	96.49%	+13.6%
Sep 2002	84.94%	-0.2%
Jun 2002	85.10%	-0.7%
Mar 2002	85.67%	+3.9%
Dec 2001	82.44%	-3.1%
Sep 2001	85.10%	+0.1%
Jun 2001	85.04%	+1.3%
Mar 2001	83.99%	+4.2%
Dec 2000	80.62%	-3.4%
Sep 2000	83.43%	-0.2%
Jun 2000	83.60%	-5.4%
Mar 2000	88.41%	+5.7%
Dec 1999	83.66%	+4.9%
Sep 1999	79.73%	-16.9%
Jun 1999	95.95%	+11.8%
Mar 1999	85.82%	+4.5%
Dec 1998	82.16%	-4.2%
Sep 1998	85.77%	+2.3%
Jun 1998	83.87%	+0.2%
Mar 1998	83.68%	-3.0%
Dec 1997	86.26%	-3.4%
Sep 1997	89.26%	+2.6%
Jun 1997	86.96%	+1.5%
Mar 1997	85.64%	-9.7%
Dec 1996	94.82%	+11.5%
Sep 1996	85.02%	+0.7%
Jun 1996	84.40%	-0.3%
Mar 1996	84.64%	+1.7%
Dec 1995	83.25%	+2.4%
Sep 1995	81.26%	+2.4%
Jun 1995	79.34%	-3.1%
Mar 1995	81.86%	+2.8%
Dec 1994	79.66%	-1.0%
Sep 1994	80.49%	+1.3%
Jun 1994	79.49%	-2.8%
Mar 1994	81.79%	+2.9%
Dec 1993	79.48%	-0.8%
Sep 1993	80.10%	+1.9%
Jun 1993	78.61%	-2.5%
Mar 1993	80.65%	+5.4%
Dec 1992	76.50%	+1.9%
Sep 1992	75.10%	+0.6%
Jun 1992	74.63%	-2.0%
Mar 1992	76.14%	+8.6%
Dec 1991	70.09%	-3.7%
Sep 1991	72.78%	+1.1%
Jun 1991	72.01%	-0.9%
Mar 1991	72.64%	+9.2%
Dec 1990	66.51%	-3.0%
Sep 1990	68.60%	+0.6%
Jun 1990	68.16%	-2.7%
Mar 1990	70.04%	-

FAQ

What is the current quarterly gross margin of PFE?
As of today, PFE quarterly gross margin is 69.97%
What is PFE quarterly gross margin most recent change?
PFE quarterly gross margin was up +4.20% on December 31, 2025
What is 1-year change in PFE quarterly gross margin?
PFE quarterly gross margin is down -4.16% year-over-year
How far is PFE quarterly gross margin from its all-time high?
PFE quarterly gross margin is currently -27.48% below its historical high of 96.49% set on December 31, 2002
How does PFE quarterly gross margin rank versus sector peers?
PFE quarterly gross margin is higher than 68.67% of companies in Healthcare sector
When is PFE next earnings release?
The next earnings release for PFE is on April 28, 2026

Gross Margin Formula

Gross Margin = Gross Profit

Revenue × 100%

Data Sources & References

PFE Official Website www.pfizer.com
Most Recent Quarterly Report (10-Q) www.sec.gov/Archives/edgar/data/78003/000007800326000005/0000078003-26-000005-index.htm
Most Recent Annual Report (10-K) www.sec.gov/Archives/edgar/data/78003/000007800326000005/0000078003-26-000005-index.htm
PFE Profile on Yahoo Finance finance.yahoo.com/quote/PFE
PFE Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/pfe