Upstream Bio, Inc. (UPB)

Profile

Full Name

Upstream Bio, Inc.

Ticker

NASDAQ: UPB

Exchange

NASDAQ

Sector

Healthcare

Industry

Biotechnology

Country

United States

IPO

October 11, 2024

Indexes

Not included

Website

https://upstreambio.com

Employees

52

Key Details

Price

$19.97(+1.47%)

Market cap

Last Dividend

-

TTM Dividend yield

-

Annual revenue

$2.37M(-0.42% YoY)

Annual EPS

-$5.58(-100.00% YoY)

PE ratio

-

Next earnings date

Nov 6, 2025

Next ex-dividend date

N/A

Next split date

N/A

Quick Search

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    Analyst ratings

    Price

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    Current Price

    $19.97
    UPB price is $19.97

    30-Day Relative Volume

    1.02
    UPB 30-day relative volume is 1.02

    Price Performance

    Price Most recent change

    +1.47%
    UPB price was up +1.47% on Sep 5, 2025

    Price YTD change

    +21.47%
    UPB price is up +21.47% since January 1st

    Price 1-year change

    -
    UPB price 1-year change is unknown

    Price 3-year change

    -
    UPB price 3-year change is unknown

    Price Range

    Price All-time high

    $29.46
    UPB price is currently -32.21% below its historical high of $29.46

    Price 3-year low

    $5.14
    UPB price is currently +288.52% above its 3-year low

    Capitalization

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    Market cap

    Market cap

    $1.08B
    UPB market capitalization is $1.08 billion

    Market cap 3-year change

    -
    UPB market capitalization 3-year change is unknown

    Market cap All-time high

    $1.47B
    UPB market capitalization is currently -26.66% below its historical high of $1.47 billion

    Market cap sector rank

    73.3%
    UPB market capitalization is higher than 73.3% of companies in Healthcare sector

    Shares Outstanding

    Shares Outstanding 1-Year Change

    +5%
    UPB shares outstanding is up +5% year-on-year

    Shares Outstanding 3-Year Change

    -
    UPB shares outstanding 3-year change is unknown

    Technical Indicators

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    Beta

    1.11
    UPB beta is 1.11

    200-day SMA

    $12.34
    UPB price is currently +61.82% above its 200-day simple moving average

    50-day SMA

    $14.67
    UPB price is currently +36.09% above its 50-day simple moving average

    RSI

    67.29
    UPB 14-day relative strength index is 67.29

    Volume

    1.02
    UPB 30-day relative volume is 1.02

    ATR

    $1.36
    UPB average true range is $1.36

    10-day Historical Volatility

    102.69%
    UPB 10-day historical volatility is 102.69%

    Dividend

    Income Statement

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    Revenue

    Revenue

    $2.37M
    UPB annual revenue is $2.37 million

    Revenue Analysts estimate

    $2.77M
    UPB annual revenue is currently -14.59% lower than the consensus analysts' forecast

    Revenue 1-year change

    -0.42%
    UPB annual revenue is down -0.42% year-on-year

    Revenue Sector rank

    39.77%
    UPB annual revenue is higher than 39.77% of companies in Healthcare sector

    EPS

    EPS

    -$5.58
    UPB annual earnings per share is -$5.58

    EPS Analysts estimate

    -$2.79
    UPB annual earnings per share is currently +100.11% higher than the consensus analysts' forecast

    EPS 1-year change

    -100%
    UPB annual earnings per share is down -100% year-on-year

    EPS Sector rank

    18.49%
    UPB annual earnings per share is higher than 18.49% of companies in Healthcare sector

    Profit

    Gross profit

    $2.28M
    UPB annual gross profit is $2.28 million

    Gross margin

    96.24%
    UPB annual gross profit margin is 96.24%

    Operating profit

    -$77.76M
    UPB annual operating income is -$77.76 million

    Operating margin

    -3281.18%
    UPB annual operating profit margin is -3281.18%

    Net income

    -$62.81M
    UPB annual net profit is -$62.81 million

    Net margin

    -2650.04%
    UPB annual net profit margin is -2650.04%

    Expenses

    Total expenses

    $80.13M
    UPB annual total expenses is $80.13 million

    Operating expenses

    $80.13M
    UPB annual total operating expenses is $80.13 million

    Cost of goods sold

    $89.00K
    UPB annual cost of goods sold is $89.00 thousand

    Selling, general & administrative expenses

    $17.17M
    UPB annual SGA is $17.17 million

    Depreciation and amortization

    $89.00K
    UPB annual depreciation & amortization is $89.00 thousand

    Interest expense

    $0.00
    UPB annual interest expense is $0.00

    Income tax

    $0.00
    UPB annual income tax is $0.00

    EBIT & EBITDA

    EBIT

    -$77.76M
    UPB annual earnings before interest & taxes is -$77.76 million

    EBITDA

    -$77.67M
    UPB annual EBITDA is -$77.67 million

    Balance Sheet

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    Assets

    Total assets

    $481.72M
    UPB annual total assets is $481.72 million

    Non current assets

    $2.56M
    UPB annual long term assets is $2.56 million

    Current assets

    $479.16M
    UPB annual total current assets is $479.16 million

    Cash and cash equivalents

    $325.89M
    UPB annual cash & cash equivalents is $325.89 million

    Accounts receivable

    $613.00K
    UPB annual accounts receivable is $613.00 thousand

    Inventory

    $0.00
    UPB annual inventory is $0.00

    Liabilities

    Total liabilities

    $11.87M
    UPB annual total liabilities is $11.87 million

    Long term liabilities

    $1.13M
    UPB annual total long term liabilities is $1.13 million

    Current liabilities

    $10.74M
    UPB annual total current liabilities is $10.74 million

    Accounts payable

    $4.04M
    UPB annual accounts payable is $4.04 million

    Debt

    Total debt

    $1.83M
    UPB annual total debt is $1.83 million

    Total debt 1-year change

    +3975.56%
    UPB annual total debt is up +3975.56% year-on-year

    Long term debt

    $1.13M
    UPB annual long term debt is $1.13 million

    Short term debt

    $704.00K
    UPB annual short term debt is $704.00 thousand

    Equity & Capital

    Shareholders equity

    $469.85M
    UPB annual stockholders equity is $469.85 million

    Book value

    $469.85M
    UPB annual book value is $469.85 million

    Retained earnings

    -$190.78M
    UPB annual retained earnings is -$190.78 million

    Working capital

    $468.42M
    UPB annual working capital is $468.42 million

    Cash Flow Statement

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    Cashflow Activities

    Cash from operations

    -$59.17M
    UPB annual cash flow from operations is -$59.17 million

    Cash from operations 1-year change

    -56.02%
    UPB annual cash flow from operations is down -56.02% year-on-year

    Cash from investing

    -$59.48M
    UPB annual cash flow from investing activities is -$59.48 million

    Cash from investing 1-year change

    +28.19%
    UPB annual cash flow from investing activities is up +28.19% year-on-year

    Cash from financing

    $418.91M
    UPB annual cash flow from financing activities is $418.91 million

    Cash from financing 1-year change

    +223.36%
    UPB annual cash flow from financing activities is up +223.36% year-on-year

    CAPEX

    CAPEX

    $511.00K
    UPB annual capital expenditures is $511.00 thousand

    CAPEX 1-year change

    +254.86%
    UPB annual capital expenditures is up +254.86% year-on-year

    Free Cash Flow

    Free cash flow

    -$59.68M
    UPB annual free cash flow is -$59.68 million

    Free cash flow 1-year change

    -56.77%
    UPB annual free cash flow is down -56.77% year-on-year

    Profitability Ratios

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    Margins

    Gross margin

    96.24%
    UPB annual gross profit margin is 96.24%

    Operating margin

    -3281.18%
    UPB annual operating profit margin is -3281.18%

    Net margin

    -2650.04%
    UPB annual net profit margin is -2650.04%

    ROA & ROE

    ROA

    -20.97%
    UPB annual return on assets is -20.97%

    ROE

    -21.74%
    UPB annual return on equity is -21.74%

    Valuation

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    PE Ratio

    PE ratio

    -
    UPB price to earnings ratio value is unknown

    PE ratio Sector rank

    -
    UPB price to earnings ratio is unknown

    PB Ratio

    PB ratio

    2.63
    UPB price to book ratio is 2.63

    PB ratio Sector rank

    60.86%
    UPB price to book ratio is higher than 60.86% of companies in Healthcare sector

    PS Ratio

    PS ratio

    395.36
    UPB price to sales ratio is 395.36

    PS ratio Sector rank

    95.53%
    UPB price to sales ratio is higher than 95.53% of companies in Healthcare sector

    Enterprise value

    Enterprise value

    $684.55M
    UPB enterprise value is $684.55 million

    Enterprise value Sector rank

    69.17%
    UPB enterprise value is higher than 69.17% of companies in Healthcare sector

    EV/EBITDA

    EV/EBITDA

    -5.64
    UPB EV/EBITDA is -5.64

    EV/EBITDA Sector rank

    20.95%
    UPB EV/EBITDA is higher than 20.95% of companies in Healthcare sector

    Financial Health

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    Liquidity

    Current ratio

    44.63
    UPB annual current ratio is 44.63

    Quick ratio

    44.63
    UPB annual quick ratio is 44.63

    Leverage

    Debt to equity

    0.00
    UPB annual debt to equity ratio is 0.00

    Interest coverage ratio

    -
    UPB annual interest coverage ratio value is unknown

    Risk & Stability

    Piotroski F-Score

    -
    UPB piotroski f-score value is unknown

    Altman Z-Score

    54.52
    UPB altman z-score is 54.52

    Analyst ratings

    Recent major analysts updates

    Nov 5, 24 William Blair
    Outperform
    Nov 5, 24 TD Cowen
    Buy
    Nov 5, 24 Piper Sandler
    Overweight
    Nov 5, 24 JP Morgan
    Overweight

    Institutional Ownership

    Screeners with UPB included

    Growing Shares Outstanding
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    Healthcare sector
    • What is the ticker symbol for Upstream Bio, Inc.?
    • Does Upstream Bio, Inc. pay dividends?
    • What sector is Upstream Bio, Inc. in?
    • What industry is Upstream Bio, Inc. in?
    • What country is Upstream Bio, Inc. based in?
    • When did Upstream Bio, Inc. go public?
    • Is Upstream Bio, Inc. in the S&P 500?
    • Is Upstream Bio, Inc. in the NASDAQ 100?
    • Is Upstream Bio, Inc. in the Dow Jones?
    • When was Upstream Bio, Inc.'s last earnings report?
    • When does Upstream Bio, Inc. report earnings?

    What is the ticker symbol for Upstream Bio, Inc.?

    The ticker symbol for Upstream Bio, Inc. is NASDAQ:UPB

    Does Upstream Bio, Inc. pay dividends?

    No, Upstream Bio, Inc. does not pay dividends

    What sector is Upstream Bio, Inc. in?

    Upstream Bio, Inc. is in the Healthcare sector

    What industry is Upstream Bio, Inc. in?

    Upstream Bio, Inc. is in the Biotechnology industry

    What country is Upstream Bio, Inc. based in?

    Upstream Bio, Inc. is headquartered in United States

    When did Upstream Bio, Inc. go public?

    Upstream Bio, Inc.'s initial public offering (IPO) was on October 11, 2024

    Is Upstream Bio, Inc. in the S&P 500?

    No, Upstream Bio, Inc. is not included in the S&P 500 index

    Is Upstream Bio, Inc. in the NASDAQ 100?

    No, Upstream Bio, Inc. is not included in the NASDAQ 100 index

    Is Upstream Bio, Inc. in the Dow Jones?

    No, Upstream Bio, Inc. is not included in the Dow Jones index

    When was Upstream Bio, Inc.'s last earnings report?

    Upstream Bio, Inc.'s most recent earnings report was on August 6, 2025

    When does Upstream Bio, Inc. report earnings?

    The next expected earnings date for Upstream Bio, Inc. is November 6, 2025
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