What is the current annual operating margin of EXEL?

As of today, EXEL annual operating margin is 38.48%

What is 1-year change in EXEL annual operating margin?

EXEL annual operating margin is up +20.97% year-over-year

What is 3-year change in EXEL annual operating margin?

EXEL annual operating margin is up +207.59% over the past 3 years

How far is EXEL annual operating margin from its all-time high?

EXEL annual operating margin is currently -25.14% below its historical high of 51.40% set on December 31, 2018

How does EXEL annual operating margin rank versus sector peers?

EXEL annual operating margin is higher than 96.73% of companies in Healthcare sector

When is EXEL next annual earnings release?

The next annual earnings release for EXEL is on February 9, 2027

What is the current quarterly operating margin of EXEL?

As of today, EXEL quarterly operating margin is 40.75%

What is EXEL quarterly operating margin most recent change?

EXEL quarterly operating margin was up +3.14% on September 1, 2026

What is 1-year change in EXEL quarterly operating margin?

EXEL quarterly operating margin is down -4.99% year-over-year

How far is EXEL quarterly operating margin from its all-time high?

EXEL quarterly operating margin is currently -36.74% below its historical high of 64.42% set on September 30, 2011

How does EXEL quarterly operating margin rank versus sector peers?

EXEL quarterly operating margin is higher than 96.70% of companies in Healthcare sector

When is EXEL next earnings release?

The next earnings release for EXEL is on February 9, 2027

Exelixis, Inc. (EXEL) Operating Margin History & Chart

Annual Operating Margin

38.48%6.67%+20.97%

December 1, 2025

Summary

Current Value: As of today, EXEL annual operating margin is 38.48%, up +20.97% on December 1, 2025
Historical Performance: EXEL annual operating margin is up +207.59% over the past 3 years, up +245.42% over the past 5 years
All-Time High Comparison: EXEL annual operating margin is currently -25.14% below its historical high of 51.40% set on December 31, 2018
3-Year Low Comparison: EXEL annual operating margin is +311.99% above its 3-year low of 9.34% reached on December 31, 2023
Sector Comparison: EXEL annual operating margin is higher than 96.73% of companies in Healthcare sector

Operating Margin Chart

beforeafter

Performance

EXEL Performance
Metric	Date	Value	1Y	3Y	5Y	15Y
Annual Operating Margin	Dec 1, 25	38.48%	+21.0%	+207.6%	+245.4%	+221.4%
Quarterly Operating Margin	Sep 1, 26	40.75%	-5.0%	+1192.5%	+159.2%	-36.7%
Price	Nov 5, 26	$68.71	+70.2%	+227.2%	+254.9%	+1512.9%
PE Ratio	Nov 5, 26	20.56	+20.9%	-72.5%	-45.8%	-85.5%
Annual Revenue	Dec 1, 25	$2.32B	+7.0%	+44.0%	+134.9%	+1153.8%
Annual Operating Profit	Dec 1, 25	$892.70M	+29.4%	+343.1%	+711.1%	+1622.0%
Annual Gross Margin	Dec 1, 25	96.39%	-0.1%	-0.0%	+0.1%	+100.0%
Annual Net Margin	Dec 1, 25	33.73%	+40.3%	+198.2%	+198.0%	+167.6%

Operating Margin Highs

EXEL Annual Operating Margin Highs Comparison
Period	High	Date	Current
3Y	38.48%	Dec 1, 25	at high
5Y	38.48%	Dec 1, 25	at high
All	51.40%	Dec 31, 18	-25.1%

Operating Margin Lows

EXEL Annual Operating Margin Lows Comparison
Period	Low	Date	Current
3Y	9.34%	Dec 31, 23	+312.0%
5Y	9.34%	Dec 31, 23	+312.0%
All	-883.19%	Dec 31, 14	+104.4%

Operating Margin History

Year	Value	Change
2025	38.48%	+21.0%
2024	31.81%	+240.6%
2023	9.34%	-25.3%
2022	12.51%	-37.4%
2021	19.98%	+79.4%
2020	11.14%	-70.8%
2019	38.18%	-25.7%
2018	51.40%	+37.2%
2017	37.47%	+300.7%
2016	-18.67%	+93.3%
2015	-277.16%	+68.6%
2014	-883.19%	-38.7%
2013	-636.61%	-166.7%
2012	-238.70%	-793.7%

Year	Value	Change
2011	34.41%	+208.5%
2010	-31.70%	+60.5%
2009	-80.33%	+46.3%
2008	-149.69%	-8.2%
2007	-138.40%	-7.7%
2006	-128.46%	-3.8%
2005	-123.74%	+38.6%
2004	-201.58%	-9.0%
2003	-184.97%	+5.9%
2002	-196.55%	-22.2%
2001	-160.84%	+7.1%
2000	-173.12%	+3.0%
1999	-178.56%	+73.5%
1998	-673.24%	-

FAQ

What is the current annual operating margin of EXEL?: As of today, EXEL annual operating margin is 38.48%
What is 1-year change in EXEL annual operating margin?: EXEL annual operating margin is up +20.97% year-over-year
What is 3-year change in EXEL annual operating margin?: EXEL annual operating margin is up +207.59% over the past 3 years
How far is EXEL annual operating margin from its all-time high?: EXEL annual operating margin is currently -25.14% below its historical high of 51.40% set on December 31, 2018
How does EXEL annual operating margin rank versus sector peers?: EXEL annual operating margin is higher than 96.73% of companies in Healthcare sector
When is EXEL next annual earnings release?: The next annual earnings release for EXEL is on February 9, 2027

Operating Margin Formula

Operating Profit Margin = Operating Income

Revenue × 100%

Quarterly Operating Margin

40.75%1.24%+3.14%

September 1, 2026

Summary

Current Value: As of today, EXEL quarterly operating margin is 40.75%, up +3.14% on September 1, 2026
Historical Performance: EXEL quarterly operating margin is down -4.99% year-over-year, up +1192.49% over the past 3 years
All-Time High Comparison: EXEL quarterly operating margin is currently -36.74% below its historical high of 64.42% set on September 30, 2011
3-Year Low Comparison: EXEL quarterly operating margin is +1192.49% above its 3-year low of -3.73% reached on an earlier date
Sector Comparison: EXEL quarterly operating margin is higher than 96.70% of companies in Healthcare sector

Performance

EXEL Performance
Metric	Date	Value	3M	1Y	3Y	5Y
Quarterly Operating Margin	Sep 1, 26	40.75%	+3.1%	-5.0%	+1192.5%	+159.2%
Annual Operating Margin	Dec 1, 25	38.48%	–	+21.0%	+207.6%	+245.4%
Price	Nov 5, 26	$68.71	+21.2%	+70.2%	+227.2%	+254.9%
PE Ratio	Nov 5, 26	20.56	+15.4%	+20.9%	-72.5%	-45.8%
Quarterly Revenue	Sep 1, 26	$658.70M	+4.8%	+10.2%	+39.6%	+100.6%
Quarterly Operating Profit	Sep 1, 26	$268.42M	+8.1%	+4.7%	+1626.6%	+420.0%
Quarterly Gross Margin	Sep 1, 26	96.02%	-0.7%	-0.9%	0.0%	-0.4%
Quarterly Net Margin	Sep 1, 26	33.11%	-1.8%	+2.3%	+10000.0%	+184.7%

Quarterly Operating Margin Highs

EXEL Quarterly Operating Margin Highs Comparison
Period	High	Date	Current
1Y	42.89%	N/A	-5.0%
3Y	43.37%	Jun 28, 24	-6.0%
5Y	43.37%	Jun 28, 24	-6.0%
All	64.42%	Sep 30, 11	-36.7%

Quarterly Operating Margin Lows

EXEL Quarterly Operating Margin Lows Comparison
Period	Low	Date	Current
1Y	39.41%	Dec 1, 25	+3.4%
3Y	-3.73%	N/A	+1192.5%
5Y	-11.34%	Dec 30, 22	+459.4%
All	-1,360.66%	Dec 31, 13	+103.0%

Quarterly Operating Margin History

Month	Value	Change
Sep 2026	40.75%	+3.1%
Jun 2026	39.51%	-4.0%
Mar 2026	41.15%	+4.4%
Dec 2025	39.41%	-8.1%
Sep 2025	42.89%	+14.1%
Jun 2025	37.58%	+11.7%
Mar 2025	33.64%	+16.6%
Dec 2024	28.84%	-17.2%
Sep 2024	34.82%	-19.7%
Jun 2024	43.37%	+196.0%
Mar 2024	14.65%	-14.1%
Dec 2023	17.05%	+557.1%
Sep 2023	-3.73%	-122.5%
Jun 2023	16.57%	+135.0%
Mar 2023	7.05%	+162.2%
Dec 2022	-11.34%	-156.5%
Sep 2022	20.06%	+0.5%
Jun 2022	19.96%	-14.6%
Mar 2022	23.38%	-9.6%
Dec 2021	25.86%	+64.5%
Sep 2021	15.72%	-50.8%
Jun 2021	31.94%	+1,978.8%
Mar 2021	-1.70%	-118.9%
Dec 2020	9.00%	+148.8%
Sep 2020	-18.43%	-163.3%
Jun 2020	29.11%	+25.1%
Mar 2020	23.27%	-27.7%
Dec 2019	32.17%	-24.4%
Sep 2019	42.55%	+11.2%
Jun 2019	38.28%	-2.4%
Mar 2019	39.24%	-19.6%
Dec 2018	48.82%	-12.1%
Sep 2018	55.54%	+20.5%
Jun 2018	46.09%	-14.9%
Mar 2018	54.13%	+74.4%
Dec 2017	31.04%	-42.3%
Sep 2017	53.84%	+91.5%
Jun 2017	28.11%	+9.2%
Mar 2017	25.73%	-53.4%
Dec 2016	55.20%	+246.1%
Sep 2016	15.95%	+129.7%
Jun 2016	-53.75%	+80.1%
Mar 2016	-270.62%	+15.2%
Dec 2015	-318.98%	+11.5%
Sep 2015	-360.25%	+4.0%
Jun 2015	-375.24%	-51.9%
Mar 2015	-247.03%	+57.5%
Dec 2014	-581.35%	+23.5%
Sep 2014	-760.07%	+18.7%
Jun 2014	-935.04%	+29.4%
Mar 2014	-1,324.00%	+2.7%
Dec 2013	-1,360.66%	-33.3%
Sep 2013	-1,020.42%	-138.7%
Jun 2013	-427.51%	-22.0%

Month	Value	Change
Mar 2013	-350.51%	+20.6%
Dec 2012	-441.60%	-137.9%
Sep 2012	-185.61%	+56.0%
Jun 2012	-421.91%	-247.2%
Mar 2012	-121.51%	-304.2%
Dec 2011	59.50%	-7.6%
Sep 2011	64.42%	+206.1%
Jun 2011	-60.70%	-14.9%
Mar 2011	-52.83%	-199.7%
Dec 2010	-17.63%	-148.3%
Sep 2010	-7.10%	+79.2%
Jun 2010	-34.06%	+54.2%
Mar 2010	-74.38%	-8.2%
Dec 2009	-68.75%	-172.8%
Sep 2009	-25.20%	+81.0%
Jun 2009	-132.74%	+4.0%
Mar 2009	-138.24%	-12.3%
Dec 2008	-123.14%	+17.4%
Sep 2008	-149.02%	+6.9%
Jun 2008	-160.08%	+4.3%
Mar 2008	-167.19%	-14.4%
Dec 2007	-146.19%	+8.0%
Sep 2007	-158.90%	-21.4%
Jun 2007	-130.91%	-10.4%
Mar 2007	-118.56%	-4.6%
Dec 2006	-113.38%	+15.4%
Sep 2006	-134.07%	-20.2%
Jun 2006	-111.54%	+34.9%
Mar 2006	-171.41%	+16.5%
Dec 2005	-205.16%	-5.9%
Sep 2005	-193.69%	-589.3%
Jun 2005	-28.10%	+86.6%
Mar 2005	-209.42%	-31.3%
Dec 2004	-159.51%	+24.2%
Sep 2004	-210.38%	+1.1%
Jun 2004	-212.80%	+9.9%
Mar 2004	-236.07%	-40.1%
Dec 2003	-168.47%	+14.5%
Sep 2003	-197.12%	-5.4%
Jun 2003	-186.97%	+1.1%
Mar 2003	-189.03%	-12.4%
Dec 2002	-168.15%	+23.7%
Sep 2002	-220.29%	+10.7%
Jun 2002	-246.70%	-43.3%
Mar 2002	-172.18%	-37.2%
Dec 2001	-125.53%	+13.4%
Sep 2001	-145.00%	+31.9%
Jun 2001	-212.91%	-14.4%
Mar 2001	-186.07%	-10.4%
Dec 2000	-168.60%	+6.1%
Sep 2000	-179.60%	+20.4%
Jun 2000	-225.61%	-84.5%
Mar 2000	-122.28%	-

FAQ

What is the current quarterly operating margin of EXEL?: As of today, EXEL quarterly operating margin is 40.75%
What is EXEL quarterly operating margin most recent change?: EXEL quarterly operating margin was up +3.14% on September 1, 2026
What is 1-year change in EXEL quarterly operating margin?: EXEL quarterly operating margin is down -4.99% year-over-year
How far is EXEL quarterly operating margin from its all-time high?: EXEL quarterly operating margin is currently -36.74% below its historical high of 64.42% set on September 30, 2011
How does EXEL quarterly operating margin rank versus sector peers?: EXEL quarterly operating margin is higher than 96.70% of companies in Healthcare sector
When is EXEL next earnings release?: The next earnings release for EXEL is on February 9, 2027

Operating Margin Formula

Operating Profit Margin = Operating Income

Revenue × 100%

Data Sources & References

EXEL Official Website www.exelixis.com
EXEL Profile on Yahoo Finance finance.yahoo.com/quote/EXEL
EXEL Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/exel