What is the current annual gross profit of MDGL?

As of today, MDGL annual gross profit is $900.75M

What is 1-year change in MDGL annual gross profit?

MDGL annual gross profit is up +421.25% year-over-year

What is 3-year change in MDGL annual gross profit?

MDGL annual gross profit is up +192979.87% over the past 3 years

How far is MDGL annual gross profit from its all-time high?

MDGL annual gross profit is currently at its all-time high

How does MDGL annual gross profit rank versus sector peers?

MDGL annual gross profit is higher than 90.22% of companies in Healthcare sector

When is MDGL next annual earnings release?

As of today, the next annual earnings release for MDGL has not been scheduled

What is the current quarterly gross profit of MDGL?

As of today, MDGL quarterly gross profit is $323.86M

What is MDGL quarterly gross profit most recent change?

MDGL quarterly gross profit was up +13.99% on June 30, 2026

What is 1-year change in MDGL quarterly gross profit?

MDGL quarterly gross profit is up +59.26% year-over-year

How far is MDGL quarterly gross profit from its all-time high?

MDGL quarterly gross profit is currently at its all-time high

How does MDGL quarterly gross profit rank versus sector peers?

MDGL quarterly gross profit is higher than 90.74% of companies in Healthcare sector

When is MDGL next earnings release?

The next earnings release for MDGL is on November 4, 2026

What is the current TTM gross profit of MDGL?

As of today, MDGL TTM gross profit is $1.17B

What is MDGL TTM gross profit most recent change?

MDGL TTM gross profit was up +11.45% on June 30, 2026

What is 1-year change in MDGL TTM gross profit?

MDGL TTM gross profit is up +136.99% year-over-year

How far is MDGL TTM gross profit from its all-time high?

MDGL TTM gross profit is currently at its all-time high

How does MDGL TTM gross profit rank versus sector peers?

MDGL TTM gross profit is higher than 90.36% of companies in Healthcare sector

When is MDGL next earnings release?

The next earnings release for MDGL is on November 4, 2026

MDGL Gross Profit History & Chart Since 2002

Annual Gross Profit

$900.75M$727.95M+421.25%

December 31, 2025

Summary

Current Value: As of today, MDGL annual gross profit is $900.75M, up +421.25% on December 31, 2025
Historical Performance: MDGL annual gross profit is up +192979.87% over the past 3 years, up +191341.83% over the past 5 years
All-Time High Comparison: MDGL annual gross profit is currently at its all-time high
3-Year Low Comparison: MDGL annual gross profit is +171020.11% above its 3-year low of -$527.00K reached on December 31, 2023
Sector Comparison: MDGL annual gross profit is higher than 90.22% of companies in Healthcare sector

Gross Profit Chart

beforeafter

Performance

MDGL Performance
Metric	Date	Value	1Y	3Y	5Y	15Y
Annual Gross Profit	Dec 31, 25	$900.75M	+421.3%	+10000.0%	+10000.0%	+100.0%
Quarterly Gross Profit	Jun 30, 26	$323.86M	+59.3%	+10000.0%	+10000.0%	+3528.2%
TTM Gross Profit	Jun 30, 26	$1.17B	+137.0%	+10000.0%	+10000.0%	+6552.5%
Price	Aug 14, 26	$502.44	+35.3%	+189.7%	+492.1%	+251.8%
Annual Revenue	Dec 31, 25	$958.40M	+432.1%	+100.0%	+100.0%	+6374.4%
PE Ratio	Aug 14, 26	-	–	–	–	–
Annual EPS	Dec 31, 25	-$12.85	+41.3%	+25.4%	+1.9%	+60.5%
	Dec 31, 25	$57.65M	+686.7%	+10000.0%	+10000.0%	–
Annual Gross Margin	Dec 31, 25	93.98%	-2.0%	–	–	+100.0%

Gross Profit Highs

MDGL Annual Gross Profit Highs Comparison
Period	High	Date	Current
3Y	$900.75M	Dec 31, 25	at high
5Y	$900.75M	Dec 31, 25	at high
All	$900.75M	Dec 31, 25	at high

Gross Profit Lows

MDGL Annual Gross Profit Lows Comparison
Period	Low	Date	Current
3Y	-$527.00K	Dec 31, 23	>+9999.0%
5Y	-$527.00K	Dec 31, 23	>+9999.0%
All	-$3.66M	Dec 31, 06	>+9999.0%

Gross Profit History

Year	Value	Change
2025	$900.75M	+421.3%
2024	$172.80M	>+9,900.0%
2023	-$527.00K	-12.8%
2022	-$467.00K	-15.3%
2021	-$405.00K	+14.0%
2020	-$471.00K	-320.5%
2019	-$112.00K	-16.7%
2018	-$96.00K	-24.7%
2017	-$77.00K	>-9,900.0%
2016	-$200.00	>-9,900.0%
2015	$0.00	+100.0%
2014	-$673.00K	-30.4%

Year	Value	Change
2013	-$516.00K	+30.1%
2012	-$738.00K	-112.1%
2011	$6.12M	>+9,900.0%
2010	$0.00	0.0%
2009	$0.00	0.0%
2008	$0.00	0.0%
2007	$0.00	+100.0%
2006	-$3.66M	>-9,900.0%
2005	$0.00	+100.0%
2004	-$2.96M	-1,092.3%
2003	$298.00K	>+9,900.0%
2002	$0.00	-

FAQ

What is the current annual gross profit of MDGL?: As of today, MDGL annual gross profit is $900.75M
What is 1-year change in MDGL annual gross profit?: MDGL annual gross profit is up +421.25% year-over-year
What is 3-year change in MDGL annual gross profit?: MDGL annual gross profit is up +192979.87% over the past 3 years
How far is MDGL annual gross profit from its all-time high?: MDGL annual gross profit is currently at its all-time high
How does MDGL annual gross profit rank versus sector peers?: MDGL annual gross profit is higher than 90.22% of companies in Healthcare sector
When is MDGL next annual earnings release?: As of today, the next annual earnings release for MDGL has not been scheduled

Gross Profit Formula

Gross Profit = Revenue −

Quarterly Gross Profit

$323.86M$39.76M+13.99%

June 30, 2026

Summary

Current Value: As of today, MDGL quarterly gross profit is $323.86M, up +13.99% on June 30, 2026
Historical Performance: MDGL quarterly gross profit is up +59.26% year-over-year, up +257134.92% over the past 3 years
All-Time High Comparison: MDGL quarterly gross profit is currently at its all-time high
3-Year Low Comparison: MDGL quarterly gross profit is +192876.19% above its 3-year low of -$168.00K reached on March 31, 2024
Sector Comparison: MDGL quarterly gross profit is higher than 90.74% of companies in Healthcare sector

Performance

MDGL Performance
Metric	Date	Value	3M	1Y	3Y	5Y
Quarterly Gross Profit	Jun 30, 26	$323.86M	+14.0%	+59.3%	+10000.0%	+10000.0%
Annual Gross Profit	Dec 31, 25	$900.75M	–	+421.3%	+10000.0%	+10000.0%
TTM Gross Profit	Jun 30, 26	$1.17B	+11.4%	+137.0%	+10000.0%	+10000.0%
Price	Aug 14, 26	$502.44	-6.9%	+35.3%	+189.7%	+492.1%
Quarterly Revenue	Jun 30, 26	$364.25M	+17.0%	+71.2%	+100.0%	+100.0%
PE Ratio	Aug 14, 26	-	–	–	–	–
Quarterly EPS	Jun 30, 26	-$1.99	+38.9%	-4.4%	+57.6%	+46.6%
	Jun 30, 26	$40.39M	+48.3%	+327.8%	+10000.0%	+10000.0%
Quarterly Gross Margin	Jun 30, 26	88.91%	-2.6%	-7.0%	–	–

Quarterly Gross Profit Highs

MDGL Quarterly Gross Profit Highs Comparison
Period	High	Date	Current
1Y	$323.86M	Jun 30, 26	at high
3Y	$323.86M	Jun 30, 26	at high
5Y	$323.86M	Jun 30, 26	at high
All	$323.86M	Jun 30, 26	at high

Quarterly Gross Profit Lows

MDGL Quarterly Gross Profit Lows Comparison
Period	Low	Date	Current
1Y	$203.36M	N/A	+59.3%
3Y	-$168.00K	Mar 31, 24	>+9999.0%
5Y	-$168.00K	Mar 31, 24	>+9999.0%
All	-$9.45M	Jun 30, 11	+3528.2%

Quarterly Gross Profit History

Month	Value	Change
Jun 2026	$323.86M	+14.0%
Mar 2026	$284.10M	-4.1%
Dec 2025	$296.24M	+10.2%
Sep 2025	$268.79M	+32.2%
Jun 2025	$203.36M	+53.6%
Mar 2025	$132.36M	+33.0%
Dec 2024	$99.51M	+66.6%
Sep 2024	$59.73M	+334.8%
Jun 2024	$13.74M	+8,275.6%
Mar 2024	-$168.00K	-18.3%
Dec 2023	-$142.00K	-5.2%
Sep 2023	-$135.00K	-7.1%
Jun 2023	-$126.00K	-1.6%
Mar 2023	-$124.00K	+3.9%
Dec 2022	-$129.00K	-6.6%
Sep 2022	-$121.00K	-10.0%
Jun 2022	-$110.00K	-2.8%
Mar 2022	-$107.00K	-0.9%
Dec 2021	-$106.00K	-9.3%
Sep 2021	-$97.00K	-9.0%
Jun 2021	-$89.00K	+21.2%
Mar 2021	-$113.00K	+2.6%
Dec 2020	-$116.00K	-0.9%
Sep 2020	-$115.00K	0.0%
Jun 2020	-$115.00K	+8.0%
Mar 2020	-$125.00K	-346.4%
Dec 2019	-$28.00K	0.0%
Sep 2019	-$28.00K	0.0%
Jun 2019	-$28.00K	0.0%
Mar 2019	-$28.00K	-12.0%
Dec 2018	-$25.00K	-4.2%
Sep 2018	-$24.00K	0.0%
Jun 2018	-$24.00K	-4.3%
Mar 2018	-$23.00K	+61.7%
Dec 2017	-$60.00K	-566.7%
Sep 2017	-$9,000.00	-12.5%
Jun 2017	-$8,000.00	>-9,900.0%
Mar 2017	$0.00	0.0%
Dec 2016	$0.00	0.0%
Sep 2016	$0.00	0.0%
Jun 2016	$0.00	0.0%
Mar 2016	$0.00	0.0%

Month	Value	Change
Dec 2015	$0.00	0.0%
Sep 2015	$0.00	+100.0%
Jun 2015	-$168.00K	+0.6%
Mar 2015	-$169.00K	0.0%
Dec 2014	-$169.00K	-1.2%
Sep 2014	-$167.00K	+1.2%
Jun 2014	-$169.00K	-0.6%
Mar 2014	-$168.00K	-17.5%
Dec 2013	-$143.00K	+3.4%
Sep 2013	-$148.00K	>-9,900.0%
Jun 2013	$0.00	+100.0%
Mar 2013	-$100.00K	+13.0%
Dec 2012	-$115.00K	+32.4%
Sep 2012	-$170.00K	>-9,900.0%
Jun 2012	$0.00	+100.0%
Mar 2012	-$230.00K	+97.0%
Dec 2011	-$7.73M	+18.1%
Sep 2011	-$9.44M	+0.1%
Jun 2011	-$9.45M	-8.2%
Mar 2011	-$8.73M	>-9,900.0%
Dec 2010	$0.00	0.0%
Sep 2010	$0.00	0.0%
Jun 2010	$0.00	0.0%
Mar 2010	$0.00	0.0%
Dec 2009	$0.00	0.0%
Sep 2009	$0.00	0.0%
Jun 2009	$0.00	0.0%
Mar 2009	$0.00	0.0%
Dec 2008	$0.00	0.0%
Sep 2008	$0.00	0.0%
Jun 2008	$0.00	0.0%
Mar 2008	$0.00	0.0%
Dec 2007	$0.00	+100.0%
Sep 2007	-$826.00K	+2.6%
Jun 2007	-$848.00K	-6.3%
Mar 2007	-$798.00K	+3.5%
Dec 2006	-$827.00K	+8.8%
Sep 2006	-$907.00K	+9.1%
Jun 2006	-$998.00K	-8.1%
Mar 2006	-$923.00K	>-9,900.0%
Mar 2005	$0.00	-

FAQ

What is the current quarterly gross profit of MDGL?: As of today, MDGL quarterly gross profit is $323.86M
What is MDGL quarterly gross profit most recent change?: MDGL quarterly gross profit was up +13.99% on June 30, 2026
What is 1-year change in MDGL quarterly gross profit?: MDGL quarterly gross profit is up +59.26% year-over-year
How far is MDGL quarterly gross profit from its all-time high?: MDGL quarterly gross profit is currently at its all-time high
How does MDGL quarterly gross profit rank versus sector peers?: MDGL quarterly gross profit is higher than 90.74% of companies in Healthcare sector
When is MDGL next earnings release?: The next earnings release for MDGL is on November 4, 2026

Gross Profit Formula

Gross Profit = Revenue −

TTM Gross Profit

$1.17B$120.50M+11.45%

June 30, 2026

Summary

Current Value: As of today, MDGL TTM gross profit is $1.17B, up +11.45% on June 30, 2026
Historical Performance: MDGL TTM gross profit is up +136.99% year-over-year, up +234699.80% over the past 3 years
All-Time High Comparison: MDGL TTM gross profit is currently at its all-time high
3-Year Low Comparison: MDGL TTM gross profit is +205528.90% above its 3-year low of -$571.00K reached on March 31, 2024
Sector Comparison: MDGL TTM gross profit is higher than 90.36% of companies in Healthcare sector

Performance

MDGL Performance
Metric	Date	Value	3M	1Y	3Y	5Y
TTM Gross Profit	Jun 30, 26	$1.17B	+11.4%	+137.0%	+10000.0%	+10000.0%
Annual Gross Profit	Dec 31, 25	$900.75M	–	+421.3%	+10000.0%	+10000.0%
Quarterly Gross Profit	Jun 30, 26	$323.86M	+14.0%	+59.3%	+10000.0%	+10000.0%
Price	Aug 14, 26	$502.44	-6.9%	+35.3%	+189.7%	+492.1%
TTM Revenue	Jun 30, 26	$1.28B	+13.4%	+149.0%	+100.0%	+100.0%
PE Ratio	Aug 14, 26	-	–	–	–	–
TTM EPS	Jun 30, 26	-$12.88	-0.7%	-0.3%	+30.9%	+11.8%
	Jun 30, 26	$110.94M	+38.7%	+438.8%	+10000.0%	+10000.0%
Quarterly Gross Margin	Jun 30, 26	88.91%	-2.6%	-7.0%	–	–

TTM Gross Profit Highs

MDGL TTM Gross Profit Highs Comparison
Period	High	Date	Current
1Y	$1.17B	Jun 30, 26	at high
3Y	$1.17B	Jun 30, 26	at high
5Y	$1.17B	Jun 30, 26	at high
All	$1.17B	Jun 30, 26	at high

TTM Gross Profit Lows

MDGL TTM Gross Profit Lows Comparison
Period	Low	Date	Current
1Y	$494.96M	N/A	+137.0%
3Y	-$571.00K	Mar 31, 24	>+9999.0%
5Y	-$571.00K	Mar 31, 24	>+9999.0%
All	-$35.34M	Dec 31, 11	+3418.9%

TTM Gross Profit History

Month	Value	Change
Jun 2026	$1.17B	+11.4%
Mar 2026	$1.05B	+16.8%
Dec 2025	$900.75M	+27.9%
Sep 2025	$704.02M	+42.2%
Jun 2025	$494.96M	+62.1%
Mar 2025	$305.33M	+76.7%
Dec 2024	$172.80M	+136.2%
Sep 2024	$73.15M	+450.4%
Jun 2024	$13.29M	+2,427.5%
Mar 2024	-$571.00K	-8.3%
Dec 2023	-$527.00K	-2.5%
Sep 2023	-$514.00K	-2.8%
Jun 2023	-$500.00K	-3.3%
Mar 2023	-$484.00K	-3.6%
Dec 2022	-$467.00K	-5.2%
Sep 2022	-$444.00K	-5.7%
Jun 2022	-$420.00K	-5.3%
Mar 2022	-$399.00K	+1.5%
Dec 2021	-$405.00K	+2.4%
Sep 2021	-$415.00K	+4.2%
Jun 2021	-$433.00K	+5.7%
Mar 2021	-$459.00K	+2.5%
Dec 2020	-$471.00K	-23.0%
Sep 2020	-$383.00K	-29.4%
Jun 2020	-$296.00K	-41.6%
Mar 2020	-$209.00K	-86.6%
Dec 2019	-$112.00K	-2.8%
Sep 2019	-$109.00K	-3.8%
Jun 2019	-$105.00K	-4.0%
Mar 2019	-$101.00K	-5.2%
Dec 2018	-$96.00K	+26.7%
Sep 2018	-$131.00K	-12.9%
Jun 2018	-$116.00K	-16.0%
Mar 2018	-$100.00K	-29.9%
Dec 2017	-$77.00K	-352.9%
Sep 2017	-$17.00K	-112.5%
Jun 2017	-$8,000.00	>-9,900.0%
Mar 2017	$0.00	0.0%
Dec 2016	$0.00	0.0%
Sep 2016	$0.00	0.0%
Jun 2016	$0.00	+100.0%
Mar 2016	-$168.00K	+50.1%

Month	Value	Change
Dec 2015	-$337.00K	+33.4%
Sep 2015	-$506.00K	+24.8%
Jun 2015	-$673.00K	+0.1%
Mar 2015	-$674.00K	-0.1%
Dec 2014	-$673.00K	-4.0%
Sep 2014	-$647.00K	-3.0%
Jun 2014	-$628.00K	-36.8%
Mar 2014	-$459.00K	-17.4%
Dec 2013	-$391.00K	-7.7%
Sep 2013	-$363.00K	+5.7%
Jun 2013	-$385.00K	0.0%
Mar 2013	-$385.00K	+25.2%
Dec 2012	-$515.00K	+93.7%
Sep 2012	-$8.13M	+53.3%
Jun 2012	-$17.39M	+35.2%
Mar 2012	-$26.84M	+24.1%
Dec 2011	-$35.34M	-28.0%
Sep 2011	-$27.62M	-51.9%
Jun 2011	-$18.18M	-108.2%
Mar 2011	-$8.73M	>-9,900.0%
Dec 2010	$0.00	0.0%
Sep 2010	$0.00	0.0%
Jun 2010	$0.00	0.0%
Mar 2010	$0.00	0.0%
Dec 2009	$0.00	0.0%
Sep 2009	$0.00	0.0%
Jun 2009	$0.00	0.0%
Mar 2009	$0.00	0.0%
Dec 2008	$0.00	0.0%
Sep 2008	$0.00	+100.0%
Jun 2008	-$826.00K	+50.7%
Mar 2008	-$1.67M	+32.3%
Dec 2007	-$2.47M	+25.1%
Sep 2007	-$3.30M	+2.4%
Jun 2007	-$3.38M	+4.2%
Mar 2007	-$3.53M	+3.4%
Dec 2006	-$3.66M	-29.2%
Sep 2006	-$2.83M	-47.2%
Jun 2006	-$1.92M	-108.1%
Mar 2006	-$923.00K	>-9,900.0%
Mar 2005	$0.00	-

FAQ

What is the current TTM gross profit of MDGL?: As of today, MDGL TTM gross profit is $1.17B
What is MDGL TTM gross profit most recent change?: MDGL TTM gross profit was up +11.45% on June 30, 2026
What is 1-year change in MDGL TTM gross profit?: MDGL TTM gross profit is up +136.99% year-over-year
How far is MDGL TTM gross profit from its all-time high?: MDGL TTM gross profit is currently at its all-time high
How does MDGL TTM gross profit rank versus sector peers?: MDGL TTM gross profit is higher than 90.36% of companies in Healthcare sector
When is MDGL next earnings release?: The next earnings release for MDGL is on November 4, 2026

Gross Profit Formula

Gross Profit = Revenue −

Data Sources & References

MDGL Official Website www.madrigalpharma.com
Most Recent Annual Report (10-K) www.sec.gov/Archives/edgar/data/1157601/000162828026009514/0001628280-26-009514-index.htm
MDGL Profile on Yahoo Finance finance.yahoo.com/quote/MDGL
MDGL Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/mdgl