Annual Operating Profit
-$501.88M$305.18M-155.15%
Summary
- Current Value
- As of today, DNLI annual operating profit is -$501.88M, down -155.15% on
- Historical Performance
- DNLI annual operating profit is down -69.70% over the past 3 years, and down -135.42% over the past 5 years
- All-Time High Comparison
- DNLI annual operating profit is currently -900.21% below its historical high of $62.72M set on
- 3-Year Low Comparison
- DNLI annual operating profit is at its 3-year low
- Sector Comparison
- DNLI annual operating profit is higher than 1.78% of companies in Healthcare sector
Operating Profit Chart
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Series
SUGGESTED SERIES
Performance
| Metric | Date | Value | 1Y | 3Y | 5Y | 15Y |
|---|---|---|---|---|---|---|
| Annual Operating Profit | -$501.88M | -155.2% | -69.7% | -135.4% | -2909.0% | |
| Quarterly Operating Profit | -$137.43M | -11.6% | -27.9% | -128.6% | -344.3% | |
| TTM Operating Profit | -$547.82M | -8.6% | -75.3% | -129.1% | -1671.1% | |
| Price | $16.95 | -20.0% | -41.3% | -77.1% | – | |
| PE Ratio | - | – | – | – | – | |
| Annual Revenue | $0.00 | -100.0% | -100.0% | -100.0% | 0.0% | |
| Annual EPS | -$2.57 | -143.1% | -7.5% | -24.4% | -1279.0% | |
| Annual Gross Profit | -$7.80M | -102.5% | -118.1% | -100.0% | -6342.1% | |
| Annual Operating Expenses | $501.88M | -4.8% | +45.7% | +109.2% | +2909.0% |
Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 3Y | -$196.70M | -155.2% | |
| 5Y | $62.72M | N/A | -900.2% |
| All | $62.72M | -900.2% |
Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 3Y | -$501.88M | at low | |
| 5Y | -$501.88M | at low | |
| All | -$501.88M | at low |
Operating Profit History
| Year | Value | Change |
|---|---|---|
| -$501.88M | -155.2% | |
| -$196.70M | +42.3% | |
| -$340.74M | -15.2% | |
| -$295.75M | -571.6% | |
| $62.72M | +129.4% |
| Year | Value | Change |
|---|---|---|
| -$213.18M | -359.7% | |
| -$46.37M | +48.6% | |
| -$90.14M | -3.1% | |
| -$87.43M | -424.2% | |
| -$16.68M | - |
FAQ
What is the current annual operating profit of DNLI?
As of today, DNLI annual operating profit is -$501.88M
What is 1-year change in DNLI annual operating profit?
DNLI annual operating profit is down -155.15% year-over-year
What is 3-year change in DNLI annual operating profit?
DNLI annual operating profit is down -69.70% over the past 3 years
How far is DNLI annual operating profit from its all-time high?
DNLI annual operating profit is currently -900.21% below its historical high of $62.72M set on December 31, 2020
How does DNLI annual operating profit rank versus sector peers?
DNLI annual operating profit is higher than 1.78% of companies in Healthcare sector
When is DNLI next annual earnings release?
The next annual earnings release for DNLI is on
Quarterly Operating Profit
-$137.43M$2.47M-1.83%
Summary
- Current Value
- As of today, DNLI quarterly operating profit is -$137.43M, down -1.83% on
- Historical Performance
- DNLI quarterly operating profit is down -11.57% year-over-year, and down -27.86% over the past 3 years
- All-Time High Comparison
- DNLI quarterly operating profit is currently -156.31% below its historical high of $244.08M set on
- 3-Year Low Comparison
- DNLI quarterly operating profit is +5.60% above its 3-year low of -$145.58M reached on
- Sector Comparison
- DNLI quarterly operating profit is higher than 1.69% of companies in Healthcare sector
Performance
| Metric | Date | Value | 3M | 1Y | 3Y | 5Y |
|---|---|---|---|---|---|---|
| Quarterly Operating Profit | -$137.43M | -1.8% | -11.6% | -27.9% | -128.6% | |
| Annual Operating Profit | -$501.88M | – | -155.2% | -69.7% | -135.4% | |
| TTM Operating Profit | -$547.82M | -2.7% | -8.6% | -75.3% | -129.1% | |
| Price | $16.95 | +13.8% | -20.0% | -41.3% | -77.1% | |
| PE Ratio | - | – | – | – | – | |
| Quarterly Revenue | $0.00 | 0.0% | 0.0% | -100.0% | -100.0% | |
| Quarterly EPS | -$0.74 | -1.7% | -16.4% | +12.0% | -35.9% | |
| Quarterly Gross Profit | -$2.95M | +3.2% | -60.3% | -229.1% | -100.0% | |
| Quarterly Operating Expenses | $134.49M | +1.9% | +10.8% | +22.5% | +123.7% |
Quarterly Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 1Y | -$129.85M | N/A | -5.8% |
| 3Y | $170.48M | -180.6% | |
| 5Y | $244.08M | N/A | -156.3% |
| All | $244.08M | -156.3% |
Quarterly Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 1Y | -$145.58M | +5.6% | |
| 3Y | -$145.58M | +5.6% | |
| 5Y | -$145.58M | +5.6% | |
| All | -$145.58M | +5.6% |
Quarterly Operating Profit History
FAQ
What is the current quarterly operating profit of DNLI?
As of today, DNLI quarterly operating profit is -$137.43M
What is DNLI quarterly operating profit most recent change?
DNLI quarterly operating profit was down -1.83% on September 30, 2025
What is 1-year change in DNLI quarterly operating profit?
DNLI quarterly operating profit is down -11.57% year-over-year
How far is DNLI quarterly operating profit from its all-time high?
DNLI quarterly operating profit is currently -156.31% below its historical high of $244.08M set on December 31, 2020
How does DNLI quarterly operating profit rank versus sector peers?
DNLI quarterly operating profit is higher than 1.69% of companies in Healthcare sector
When is DNLI next earnings release?
The next earnings release for DNLI is on
TTM Operating Profit
-$547.82M$14.25M-2.67%
Summary
- Current Value
- As of today, DNLI TTM operating profit is -$547.82M, down -2.67% on
- Historical Performance
- DNLI TTM operating profit is down -8.56% year-over-year, and down -75.29% over the past 3 years
- All-Time High Comparison
- DNLI TTM operating profit is currently -973.47% below its historical high of $62.72M set on
- 3-Year Low Comparison
- DNLI TTM operating profit is at its 3-year low
- Sector Comparison
- DNLI TTM operating profit is higher than 1.25% of companies in Healthcare sector
Performance
| Metric | Date | Value | 3M | 1Y | 3Y | 5Y |
|---|---|---|---|---|---|---|
| TTM Operating Profit | -$547.82M | -2.7% | -8.6% | -75.3% | -129.1% | |
| Annual Operating Profit | -$501.88M | – | -155.2% | -69.7% | -135.4% | |
| Quarterly Operating Profit | -$137.43M | -1.8% | -11.6% | -27.9% | -128.6% | |
| Price | $16.95 | +13.8% | -20.0% | -41.3% | -77.1% | |
| PE Ratio | - | – | – | – | – | |
| TTM Revenue | $0.00 | 0.0% | 0.0% | -100.0% | -100.0% | |
| TTM EPS | -$2.91 | -3.7% | -5.3% | -18.2% | -31.3% | |
| TTM Gross Profit | -$10.17M | -12.2% | -25.3% | -109.6% | -100.0% | |
| Quarterly Operating Expenses | $134.49M | +1.9% | +10.8% | +22.5% | +123.7% |
TTM Operating Profit Highs
| Period | High | Date | Current |
|---|---|---|---|
| 1Y | -$501.88M | N/A | -9.2% |
| 3Y | -$163.16M | -235.8% | |
| 5Y | $62.72M | N/A | -973.5% |
| All | $62.72M | -973.5% |
TTM Operating Profit Lows
| Period | Low | Date | Current |
|---|---|---|---|
| 1Y | -$547.82M | at low | |
| 3Y | -$547.82M | at low | |
| 5Y | -$547.82M | at low | |
| All | -$547.82M | at low |
TTM Operating Profit History
FAQ
What is the current TTM operating profit of DNLI?
As of today, DNLI TTM operating profit is -$547.82M
What is DNLI TTM operating profit most recent change?
DNLI TTM operating profit was down -2.67% on September 30, 2025
What is 1-year change in DNLI TTM operating profit?
DNLI TTM operating profit is down -8.56% year-over-year
How far is DNLI TTM operating profit from its all-time high?
DNLI TTM operating profit is currently -973.47% below its historical high of $62.72M set on December 31, 2020
How does DNLI TTM operating profit rank versus sector peers?
DNLI TTM operating profit is higher than 1.25% of companies in Healthcare sector
When is DNLI next earnings release?
The next earnings release for DNLI is on
Operating Profit Formula
Operating Profit = −
Data Sources & References
- DNLI Official Website www.denalitherapeutics.com
- Most Recent Quarterly Report (10-Q) www.sec.gov/Archives/edgar/data/1714899/000171489925000193/0001714899-25-000193-index.htm
- Most Recent Annual Report (10-K) www.sec.gov/Archives/edgar/data/1714899/000171489925000066/0001714899-25-000066-index.htm
- DNLI Profile on Yahoo Finance finance.yahoo.com/quote/DNLI
- DNLI Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/dnli