What is the current annual operating margin of ALNY?

As of today, ALNY annual operating margin is 13.51%

What is 1-year change in ALNY annual operating margin?

ALNY annual operating margin is up +271.66% year-over-year

What is 3-year change in ALNY annual operating margin?

ALNY annual operating margin is up +117.85% over the past 3 years

How far is ALNY annual operating margin from its all-time high?

ALNY annual operating margin is currently at its all-time high

How does ALNY annual operating margin rank versus sector peers?

ALNY annual operating margin is higher than 83.52% of companies in Healthcare sector

When is ALNY next annual earnings release?

As of today, the next annual earnings release for ALNY has not been scheduled

What is the current quarterly operating margin of ALNY?

As of today, ALNY quarterly operating margin is 17.93%

What is ALNY quarterly operating margin most recent change?

ALNY quarterly operating margin was down -22.11% on June 30, 2026

What is 1-year change in ALNY quarterly operating margin?

ALNY quarterly operating margin is up +957.89% year-over-year

How far is ALNY quarterly operating margin from its all-time high?

ALNY quarterly operating margin is currently -39.14% below its historical high of 29.46% set on September 30, 2025

How does ALNY quarterly operating margin rank versus sector peers?

ALNY quarterly operating margin is higher than 85.80% of companies in Healthcare sector

When is ALNY next earnings release?

The next earnings release for ALNY is on October 29, 2026

ALNY Operating Margin History & Chart Since 2003

Annual Operating Margin

13.51%21.38%+271.66%

December 31, 2025

Summary

Current Value: As of today, ALNY annual operating margin is 13.51%, up +271.66% on December 31, 2025
Historical Performance: ALNY annual operating margin is up +117.85% over the past 3 years, up +108.04% over the past 5 years
All-Time High Comparison: ALNY annual operating margin is currently at its all-time high
3-Year Low Comparison: ALNY annual operating margin is +117.85% above its 3-year low of -75.68% reached on an earlier date
Sector Comparison: ALNY annual operating margin is higher than 83.52% of companies in Healthcare sector

Operating Margin Chart

beforeafter

Performance

ALNY Performance
Metric	Date	Value	1Y	3Y	5Y	15Y
Annual Operating Margin	Dec 31, 25	13.51%	+271.7%	+117.8%	+108.0%	+130.7%
Quarterly Operating Margin	Jun 30, 26	17.93%	+957.9%	+124.9%	+127.1%	+128.2%
Price	Aug 7, 26	$219.20	-49.6%	+18.9%	+12.3%	+2799.5%
PE Ratio	Aug 7, 26	37.01	–	–	–	–
Annual Revenue	Dec 31, 25	$3.71B	+65.2%	+258.0%	+653.6%	+3612.4%
Annual Operating Profit	Dec 31, 25	$501.58M	+383.6%	+163.9%	+160.6%	+1238.1%
Annual Gross Margin	Dec 31, 25	81.64%	-4.7%	-2.5%	-3.0%	-14.1%
Annual Net Margin	Dec 31, 25	8.45%	+168.3%	+107.8%	+104.8%	+119.4%

Operating Margin Highs

ALNY Annual Operating Margin Highs Comparison
Period	High	Date	Current
3Y	13.51%	Dec 31, 25	at high
5Y	13.51%	Dec 31, 25	at high
All	13.51%	Dec 31, 25	at high

Operating Margin Lows

ALNY Annual Operating Margin Lows Comparison
Period	Low	Date	Current
3Y	-75.68%	N/A	+117.8%
5Y	-168.09%	N/A	+108.0%
All	-11.62%	Dec 31, 03	+100.1%

Operating Margin History

Year	Value	Change
2025	13.51%	+271.7%
2024	-7.87%	+49.0%
2023	-15.43%	+79.6%
2022	-75.68%	+9.8%
2021	-83.94%	+50.1%
2020	-168.09%	+60.7%
2019	-427.50%	+60.7%
2018	-1,087.56%	-95.5%
2017	-556.20%	+38.2%
2016	-900.33%	-25.0%
2015	-720.27%	-97.7%
2014	-364.34%	-84.9%

Year	Value	Change
2013	-197.05%	-106.8%
2012	-95.27%	-43.8%
2011	-66.24%	-50.4%
2010	-44.05%	+8.0%
2009	-47.86%	-65.3%
2008	-28.95%	+83.5%
2007	-175.60%	-19.7%
2006	-146.68%	+80.7%
2005	-760.53%	-0.8%
2004	-754.18%	+93.5%
2003	-11.62%	-

FAQ

What is the current annual operating margin of ALNY?: As of today, ALNY annual operating margin is 13.51%
What is 1-year change in ALNY annual operating margin?: ALNY annual operating margin is up +271.66% year-over-year
What is 3-year change in ALNY annual operating margin?: ALNY annual operating margin is up +117.85% over the past 3 years
How far is ALNY annual operating margin from its all-time high?: ALNY annual operating margin is currently at its all-time high
How does ALNY annual operating margin rank versus sector peers?: ALNY annual operating margin is higher than 83.52% of companies in Healthcare sector
When is ALNY next annual earnings release?: As of today, the next annual earnings release for ALNY has not been scheduled

Operating Margin Formula

Operating Profit Margin = Operating Income

Revenue × 100%

Quarterly Operating Margin

17.93%5.09%-22.11%

June 30, 2026

Summary

Current Value: As of today, ALNY quarterly operating margin is 17.93%, down -22.11% on June 30, 2026
Historical Performance: ALNY quarterly operating margin is up +957.89% year-over-year, up +124.87% over the past 3 years
All-Time High Comparison: ALNY quarterly operating margin is currently -39.14% below its historical high of 29.46% set on September 30, 2025
3-Year Low Comparison: ALNY quarterly operating margin is +124.87% above its 3-year low of -72.10% reached on an earlier date
Sector Comparison: ALNY quarterly operating margin is higher than 85.80% of companies in Healthcare sector

Performance

ALNY Performance
Metric	Date	Value	3M	1Y	3Y	5Y
Quarterly Operating Margin	Jun 30, 26	17.93%	-22.1%	+957.9%	+124.9%	+127.1%
Annual Operating Margin	Dec 31, 25	13.51%	–	+271.7%	+117.8%	+108.0%
Price	Aug 7, 26	$219.20	-25.9%	-49.6%	+18.9%	+12.3%
PE Ratio	Aug 7, 26	37.01	-47.9%	–	–	–
Quarterly Revenue	Jun 30, 26	$1.29B	+10.6%	+66.9%	+305.0%	+485.3%
Quarterly Operating Profit	Jun 30, 26	$231.44M	-13.8%	+1528.7%	+200.7%	+258.4%
Quarterly Gross Margin	Jun 30, 26	76.88%	-6.1%	-5.7%	+5.0%	-6.7%
Quarterly Net Margin	Jun 30, 26	12.74%	-27.8%	+236.4%	+114.7%	+114.8%

Quarterly Operating Margin Highs

ALNY Quarterly Operating Margin Highs Comparison
Period	High	Date	Current
1Y	29.46%	Sep 30, 25	-39.1%
3Y	29.46%	Sep 30, 25	-39.1%
5Y	29.46%	Sep 30, 25	-39.1%
All	29.46%	Sep 30, 25	-39.1%

Quarterly Operating Margin Lows

ALNY Quarterly Operating Margin Lows Comparison
Period	Low	Date	Current
1Y	-2.09%	N/A	+957.9%
3Y	-72.10%	N/A	+124.9%
5Y	-97.63%	Sep 30, 22	+118.4%
All	-46.77%	Dec 31, 03	+100.0%

Quarterly Operating Margin History

Month	Value	Change
Jun 2026	17.93%	-22.1%
Mar 2026	23.02%	+91.7%
Dec 2025	12.01%	-59.2%
Sep 2025	29.46%	+1,509.6%
Jun 2025	-2.09%	-168.8%
Mar 2025	3.04%	+117.1%
Dec 2024	-17.73%	-15.5%
Sep 2024	-15.35%	-308.3%
Jun 2024	7.37%	+183.8%
Mar 2024	-8.79%	+66.8%
Dec 2023	-26.47%	-192.9%
Sep 2023	28.50%	+139.5%
Jun 2023	-72.10%	-53.7%
Mar 2023	-46.92%	+16.7%
Dec 2022	-56.30%	+42.3%
Sep 2022	-97.63%	-14.5%
Jun 2022	-85.26%	-23.9%
Mar 2022	-68.80%	+8.6%
Dec 2021	-75.26%	+22.3%
Sep 2021	-96.83%	-46.1%
Jun 2021	-66.27%	+36.8%
Mar 2021	-104.89%	+11.7%
Dec 2020	-118.75%	+33.6%
Sep 2020	-178.94%	+6.5%
Jun 2020	-191.28%	+9.5%
Mar 2020	-211.27%	+49.2%
Dec 2019	-415.83%	-34.7%
Sep 2019	-308.73%	+41.6%
Jun 2019	-528.41%	+6.8%
Mar 2019	-567.03%	+45.9%
Dec 2018	-1,047.67%	+91.5%
Sep 2018	-12.30%	-1,812.9%
Jun 2018	-643.17%	+4.4%
Mar 2018	-673.11%	-73.3%
Dec 2017	-388.42%	+47.2%
Sep 2017	-735.84%	+2.7%
Jun 2017	-756.18%	-34.6%
Mar 2017	-561.77%	+15.1%
Dec 2016	-661.36%	+15.4%
Sep 2016	-781.45%	+26.4%
Jun 2016	-1,061.55%	+29.1%
Mar 2016	-1,498.00%	-22.3%
Dec 2015	-1,225.16%	+1.1%
Sep 2015	-1,238.61%	-47.5%
Jun 2015	-839.88%	-198.1%
Mar 2015	-281.72%	-48.0%

Month	Value	Change
Dec 2014	-190.32%	+53.8%
Sep 2014	-411.95%	+38.5%
Jun 2014	-670.25%	-24.9%
Mar 2014	-536.65%	-96.7%
Dec 2013	-272.81%	+23.9%
Sep 2013	-358.51%	-46.1%
Jun 2013	-245.33%	-366.5%
Mar 2013	-52.59%	+80.9%
Dec 2012	-274.90%	-153.9%
Sep 2012	-108.28%	-87.4%
Jun 2012	-57.78%	-9.2%
Mar 2012	-52.91%	+20.3%
Dec 2011	-66.42%	-11.0%
Sep 2011	-59.82%	+6.0%
Jun 2011	-63.64%	+15.2%
Mar 2011	-75.02%	-28.1%
Dec 2010	-58.56%	-85.6%
Sep 2010	-31.55%	+27.8%
Jun 2010	-43.68%	+5.1%
Mar 2010	-46.03%	-51.9%
Dec 2009	-30.31%	+23.8%
Sep 2009	-39.80%	+56.3%
Jun 2009	-91.10%	-186.0%
Mar 2009	-31.85%	+0.5%
Dec 2008	-32.02%	-154.7%
Sep 2008	-12.57%	+76.7%
Jun 2008	-53.84%	-202.0%
Mar 2008	-17.83%	-12.4%
Dec 2007	-15.86%	+94.6%
Sep 2007	-291.38%	-78.0%
Jun 2007	-163.73%	+50.8%
Mar 2007	-332.47%	-132.3%
Dec 2006	-143.12%	-36.6%
Sep 2006	-104.79%	+43.2%
Jun 2006	-184.50%	-7.7%
Mar 2006	-171.37%	+82.2%
Dec 2005	-961.15%	-27.3%
Sep 2005	-755.13%	+25.3%
Jun 2005	-1,011.19%	-148.7%
Mar 2005	-406.63%	-94.5%
Dec 2004	-209.03%	+55.5%
Sep 2004	-470.08%	+91.2%
Jun 2004	-5,324.43%	+46.5%
Mar 2004	-9,949.25%	+78.7%
Dec 2003	-46.77%	-

FAQ

What is the current quarterly operating margin of ALNY?: As of today, ALNY quarterly operating margin is 17.93%
What is ALNY quarterly operating margin most recent change?: ALNY quarterly operating margin was down -22.11% on June 30, 2026
What is 1-year change in ALNY quarterly operating margin?: ALNY quarterly operating margin is up +957.89% year-over-year
How far is ALNY quarterly operating margin from its all-time high?: ALNY quarterly operating margin is currently -39.14% below its historical high of 29.46% set on September 30, 2025
How does ALNY quarterly operating margin rank versus sector peers?: ALNY quarterly operating margin is higher than 85.80% of companies in Healthcare sector
When is ALNY next earnings release?: The next earnings release for ALNY is on October 29, 2026

Operating Margin Formula

Operating Profit Margin = Operating Income

Revenue × 100%

Data Sources & References

ALNY Official Website www.alnylam.com
Most Recent Annual Report (10-K) www.sec.gov/Archives/edgar/data/1178670/000162828026007497/0001628280-26-007497-index.htm
ALNY Profile on Yahoo Finance finance.yahoo.com/quote/ALNY
ALNY Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/alny