What is the current annual gross profit of ALNY?

As of today, ALNY annual gross profit is $3.03B

What is 1-year change in ALNY annual gross profit?

ALNY annual gross profit is up +57.52% year-over-year

What is 3-year change in ALNY annual gross profit?

ALNY annual gross profit is up +249.07% over the past 3 years

How far is ALNY annual gross profit from its all-time high?

ALNY annual gross profit is currently at its all-time high

How does ALNY annual gross profit rank versus sector peers?

ALNY annual gross profit is higher than 95.00% of companies in Healthcare sector

When is ALNY next annual earnings release?

As of today, the next annual earnings release for ALNY has not been scheduled

What is the current quarterly gross profit of ALNY?

As of today, ALNY quarterly gross profit is $992.50M

What is ALNY quarterly gross profit most recent change?

ALNY quarterly gross profit was up +3.81% on June 30, 2026

What is 1-year change in ALNY quarterly gross profit?

ALNY quarterly gross profit is up +57.36% year-over-year

How far is ALNY quarterly gross profit from its all-time high?

ALNY quarterly gross profit is currently -5.37% below its historical high of $1.05B set on September 30, 2025

How does ALNY quarterly gross profit rank versus sector peers?

ALNY quarterly gross profit is higher than 95.35% of companies in Healthcare sector

When is ALNY next earnings release?

The next earnings release for ALNY is on October 29, 2026

What is the current TTM gross profit of ALNY?

As of today, ALNY TTM gross profit is $3.83B

What is ALNY TTM gross profit most recent change?

ALNY TTM gross profit was up +10.44% on June 30, 2026

What is 1-year change in ALNY TTM gross profit?

ALNY TTM gross profit is up +85.83% year-over-year

How far is ALNY TTM gross profit from its all-time high?

ALNY TTM gross profit is currently at its all-time high

How does ALNY TTM gross profit rank versus sector peers?

ALNY TTM gross profit is higher than 95.54% of companies in Healthcare sector

When is ALNY next earnings release?

The next earnings release for ALNY is on October 29, 2026

ALNY Gross Profit History & Chart Since 2002

Annual Gross Profit

$3.03B$1.11B+57.52%

December 31, 2025

Summary

Current Value: As of today, ALNY annual gross profit is $3.03B, up +57.52% on December 31, 2025
Historical Performance: ALNY annual gross profit is up +249.07% over the past 3 years, up +630.97% over the past 5 years
All-Time High Comparison: ALNY annual gross profit is currently at its all-time high
3-Year Low Comparison: ALNY annual gross profit is +249.07% above its 3-year low of $868.60M reached on an earlier date
Sector Comparison: ALNY annual gross profit is higher than 95.00% of companies in Healthcare sector

Gross Profit Chart

beforeafter

Performance

ALNY Performance
Metric	Date	Value	1Y	3Y	5Y	15Y
Annual Gross Profit	Dec 31, 25	$3.03B	+57.5%	+249.1%	+631.0%	+3088.3%
Quarterly Gross Profit	Jun 30, 26	$992.50M	+57.4%	+325.3%	+445.9%	+100.0%
TTM Gross Profit	Jun 30, 26	$3.83B	+85.8%	+280.9%	+568.0%	+10000.0%
Price	Aug 6, 26	$216.12	-49.5%	+16.5%	+10.7%	+2758.7%
Annual Revenue	Dec 31, 25	$3.71B	+65.2%	+258.0%	+653.6%	+3612.4%
PE Ratio	Aug 6, 26	36.49	–	–	–	–
Annual EPS	Dec 31, 25	$2.33	+206.9%	+125.1%	+131.2%	+324.0%
	Dec 31, 25	$681.87M	+110.9%	+303.9%	+773.6%	+10000.0%
Annual Gross Margin	Dec 31, 25	81.64%	-4.7%	-2.5%	-3.0%	-14.1%

Gross Profit Highs

ALNY Annual Gross Profit Highs Comparison
Period	High	Date	Current
3Y	$3.03B	Dec 31, 25	at high
5Y	$3.03B	Dec 31, 25	at high
All	$3.03B	Dec 31, 25	at high

Gross Profit Lows

ALNY Annual Gross Profit Lows Comparison
Period	Low	Date	Current
3Y	$868.60M	N/A	+249.1%
5Y	$414.80M	N/A	+631.0%
All	$0.00	Dec 31, 02	N/A

Gross Profit History

Year	Value	Change
2025	$3.03B	+57.5%
2024	$1.92B	+26.8%
2023	$1.52B	+74.8%
2022	$868.60M	+23.4%
2021	$704.14M	+69.8%
2020	$414.80M	+113.1%
2019	$194.69M	+192.0%
2018	$66.67M	-12.9%
2017	$76.55M	>+9,900.0%
2016	$0.00	0.0%
2015	$0.00	0.0%
2014	$0.00	0.0%

Year	Value	Change
2013	$0.00	0.0%
2012	$0.00	-100.0%
2011	$77.63M	-18.4%
2010	$95.10M	+0.6%
2009	$94.54M	>+9,900.0%
2008	$0.00	0.0%
2007	$0.00	0.0%
2006	$0.00	0.0%
2005	$0.00	0.0%
2004	$0.00	0.0%
2003	$0.00	0.0%
2002	$0.00	-

FAQ

What is the current annual gross profit of ALNY?: As of today, ALNY annual gross profit is $3.03B
What is 1-year change in ALNY annual gross profit?: ALNY annual gross profit is up +57.52% year-over-year
What is 3-year change in ALNY annual gross profit?: ALNY annual gross profit is up +249.07% over the past 3 years
How far is ALNY annual gross profit from its all-time high?: ALNY annual gross profit is currently at its all-time high
How does ALNY annual gross profit rank versus sector peers?: ALNY annual gross profit is higher than 95.00% of companies in Healthcare sector
When is ALNY next annual earnings release?: As of today, the next annual earnings release for ALNY has not been scheduled

Gross Profit Formula

Gross Profit = Revenue −

Quarterly Gross Profit

$992.50M$36.44M+3.81%

June 30, 2026

Summary

Current Value: As of today, ALNY quarterly gross profit is $992.50M, up +3.81% on June 30, 2026
Historical Performance: ALNY quarterly gross profit is up +57.36% year-over-year, up +325.26% over the past 3 years
All-Time High Comparison: ALNY quarterly gross profit is currently -5.37% below its historical high of $1.05B set on September 30, 2025
3-Year Low Comparison: ALNY quarterly gross profit is +325.26% above its 3-year low of $233.38M reached on an earlier date
Sector Comparison: ALNY quarterly gross profit is higher than 95.35% of companies in Healthcare sector

Performance

ALNY Performance
Metric	Date	Value	3M	1Y	3Y	5Y
Quarterly Gross Profit	Jun 30, 26	$992.50M	+3.8%	+57.4%	+325.3%	+445.9%
Annual Gross Profit	Dec 31, 25	$3.03B	–	+57.5%	+249.1%	+631.0%
TTM Gross Profit	Jun 30, 26	$3.83B	+10.4%	+85.8%	+280.9%	+568.0%
Price	Aug 6, 26	$216.12	-28.7%	-49.5%	+16.5%	+10.7%
Quarterly Revenue	Jun 30, 26	$1.29B	+10.6%	+66.9%	+305.0%	+485.3%
PE Ratio	Aug 6, 26	36.49	-49.9%	–	–	–
Quarterly EPS	Jun 30, 26	$1.21	-20.0%	+318.3%	+154.5%	+175.0%
	Jun 30, 26	$298.45M	+41.4%	+108.8%	+249.6%	+670.1%
Quarterly Gross Margin	Jun 30, 26	76.88%	-6.1%	-5.7%	+5.0%	-6.7%

Quarterly Gross Profit Highs

ALNY Quarterly Gross Profit Highs Comparison
Period	High	Date	Current
1Y	$1.05B	Sep 30, 25	-5.4%
3Y	$1.05B	Sep 30, 25	-5.4%
5Y	$1.05B	Sep 30, 25	-5.4%
All	$1.05B	Sep 30, 25	-5.4%

Quarterly Gross Profit Lows

ALNY Quarterly Gross Profit Lows Comparison
Period	Low	Date	Current
1Y	$630.74M	N/A	+57.4%
3Y	$233.38M	N/A	+325.3%
5Y	$154.97M	Sep 30, 21	+540.4%
All	-$1.31M	Sep 30, 18	>+9999.0%

Quarterly Gross Profit History

Month	Value	Change
Jun 2026	$992.50M	+3.8%
Mar 2026	$956.05M	+15.3%
Dec 2025	$829.31M	-20.9%
Sep 2025	$1.05B	+66.3%
Jun 2025	$630.74M	+20.6%
Mar 2025	$523.15M	+6.7%
Dec 2024	$490.35M	+18.2%
Sep 2024	$415.01M	-29.8%
Jun 2024	$591.15M	+38.0%
Mar 2024	$428.36M	+21.1%
Dec 2023	$353.86M	-46.9%
Sep 2023	$666.22M	+185.5%
Jun 2023	$233.38M	-11.7%
Mar 2023	$264.42M	-6.8%
Dec 2022	$283.77M	+27.1%
Sep 2022	$223.19M	+21.3%
Jun 2022	$184.01M	+3.6%
Mar 2022	$177.63M	-19.6%
Dec 2021	$220.87M	+42.5%
Sep 2021	$154.97M	-14.8%
Jun 2021	$181.80M	+24.1%
Mar 2021	$146.50M	+4.2%
Dec 2020	$140.54M	+35.1%
Sep 2020	$104.06M	+23.8%
Jun 2020	$84.03M	-2.5%
Mar 2020	$86.17M	+44.8%
Dec 2019	$59.51M	-8.2%
Sep 2019	$64.85M	+111.6%
Jun 2019	$30.64M	+72.8%
Mar 2019	$17.74M	-8.4%
Dec 2018	$19.37M	+1,574.0%
Sep 2018	-$1.31M	>-9,900.0%
Jun 2018	$0.00	0.0%
Mar 2018	$0.00	-100.0%
Dec 2017	$34.21M	>+9,900.0%
Sep 2017	$0.00	0.0%
Jun 2017	$0.00	0.0%
Mar 2017	$0.00	0.0%
Dec 2016	$0.00	0.0%
Sep 2016	$0.00	0.0%
Jun 2016	$0.00	0.0%
Mar 2016	$0.00	0.0%
Dec 2015	$0.00	0.0%
Sep 2015	$0.00	0.0%
Jun 2015	$0.00	0.0%

Month	Value	Change
Mar 2015	$0.00	0.0%
Dec 2014	$0.00	0.0%
Sep 2014	$0.00	0.0%
Jun 2014	$0.00	0.0%
Mar 2014	$0.00	0.0%
Dec 2013	$0.00	0.0%
Sep 2013	$0.00	0.0%
Jun 2013	$0.00	0.0%
Mar 2013	$0.00	0.0%
Dec 2012	$0.00	0.0%
Sep 2012	$0.00	-100.0%
Jun 2012	$18.28M	-1.0%
Mar 2012	$18.47M	-3.9%
Dec 2011	$19.22M	-1.6%
Sep 2011	$19.53M	>+9,900.0%
Jun 2011	$0.00	0.0%
Mar 2011	$0.00	-100.0%
Dec 2010	$19.90M	>+9,900.0%
Sep 2010	$0.00	0.0%
Jun 2010	$0.00	0.0%
Mar 2010	$0.00	0.0%
Dec 2009	$0.00	0.0%
Sep 2009	$0.00	0.0%
Jun 2009	$0.00	0.0%
Mar 2009	$0.00	0.0%
Dec 2008	$0.00	0.0%
Sep 2008	$0.00	0.0%
Jun 2008	$0.00	0.0%
Mar 2008	$0.00	0.0%
Dec 2007	$0.00	0.0%
Sep 2007	$0.00	0.0%
Jun 2007	$0.00	0.0%
Mar 2007	$0.00	0.0%
Dec 2006	$0.00	0.0%
Sep 2006	$0.00	0.0%
Jun 2006	$0.00	0.0%
Mar 2006	$0.00	0.0%
Dec 2005	$0.00	0.0%
Sep 2005	$0.00	0.0%
Jun 2005	$0.00	0.0%
Mar 2005	$0.00	0.0%
Dec 2004	$0.00	0.0%
Sep 2004	$0.00	0.0%
Jun 2004	$0.00	0.0%
Mar 2004	$0.00	-

FAQ

What is the current quarterly gross profit of ALNY?: As of today, ALNY quarterly gross profit is $992.50M
What is ALNY quarterly gross profit most recent change?: ALNY quarterly gross profit was up +3.81% on June 30, 2026
What is 1-year change in ALNY quarterly gross profit?: ALNY quarterly gross profit is up +57.36% year-over-year
How far is ALNY quarterly gross profit from its all-time high?: ALNY quarterly gross profit is currently -5.37% below its historical high of $1.05B set on September 30, 2025
How does ALNY quarterly gross profit rank versus sector peers?: ALNY quarterly gross profit is higher than 95.35% of companies in Healthcare sector
When is ALNY next earnings release?: The next earnings release for ALNY is on October 29, 2026

Gross Profit Formula

Gross Profit = Revenue −

TTM Gross Profit

$3.83B$361.76M+10.44%

June 30, 2026

Summary

Current Value: As of today, ALNY TTM gross profit is $3.83B, up +10.44% on June 30, 2026
Historical Performance: ALNY TTM gross profit is up +85.83% year-over-year, up +280.86% over the past 3 years
All-Time High Comparison: ALNY TTM gross profit is currently at its all-time high
3-Year Low Comparison: ALNY TTM gross profit is +280.86% above its 3-year low of $1.00B reached on an earlier date
Sector Comparison: ALNY TTM gross profit is higher than 95.54% of companies in Healthcare sector

Performance

ALNY Performance
Metric	Date	Value	3M	1Y	3Y	5Y
TTM Gross Profit	Jun 30, 26	$3.83B	+10.4%	+85.8%	+280.9%	+568.0%
Annual Gross Profit	Dec 31, 25	$3.03B	–	+57.5%	+249.1%	+631.0%
Quarterly Gross Profit	Jun 30, 26	$992.50M	+3.8%	+57.4%	+325.3%	+445.9%
Price	Aug 6, 26	$216.12	-28.7%	-49.5%	+16.5%	+10.7%
TTM Revenue	Jun 30, 26	$4.80B	+12.1%	+95.1%	+288.3%	+598.8%
PE Ratio	Aug 6, 26	36.49	-49.9%	–	–	–
TTM EPS	Jun 30, 26	$5.92	+42.3%	+368.0%	+168.7%	+177.9%
	Jun 30, 26	$977.45M	+18.9%	+142.7%	+320.2%	+752.6%
Quarterly Gross Margin	Jun 30, 26	76.88%	-6.1%	-5.7%	+5.0%	-6.7%

TTM Gross Profit Highs

ALNY TTM Gross Profit Highs Comparison
Period	High	Date	Current
1Y	$3.83B	Jun 30, 26	at high
3Y	$3.83B	Jun 30, 26	at high
5Y	$3.83B	Jun 30, 26	at high
All	$3.83B	Jun 30, 26	at high

TTM Gross Profit Lows

ALNY TTM Gross Profit Lows Comparison
Period	Low	Date	Current
1Y	$2.06B	N/A	+85.8%
3Y	$1.00B	N/A	+280.9%
5Y	$572.90M	N/A	+568.0%
All	$0.00	Mar 31, 04	N/A

TTM Gross Profit History

Month	Value	Change
Jun 2026	$3.83B	+10.4%
Mar 2026	$3.46B	+14.3%
Dec 2025	$3.03B	+12.6%
Sep 2025	$2.69B	+30.8%
Jun 2025	$2.06B	+2.0%
Mar 2025	$2.02B	+4.9%
Dec 2024	$1.92B	+7.6%
Sep 2024	$1.79B	-12.3%
Jun 2024	$2.04B	+21.3%
Mar 2024	$1.68B	+10.8%
Dec 2023	$1.52B	+4.8%
Sep 2023	$1.45B	+44.1%
Jun 2023	$1.00B	+5.2%
Mar 2023	$955.39M	+10.0%
Dec 2022	$868.60M	+7.8%
Sep 2022	$805.70M	+9.3%
Jun 2022	$737.48M	+0.3%
Mar 2022	$735.27M	+4.4%
Dec 2021	$704.14M	+12.9%
Sep 2021	$623.81M	+8.9%
Jun 2021	$572.90M	+20.6%
Mar 2021	$475.13M	+14.5%
Dec 2020	$414.80M	+24.3%
Sep 2020	$333.77M	+13.3%
Jun 2020	$294.56M	+22.1%
Mar 2020	$241.17M	+39.6%
Dec 2019	$172.73M	+30.3%
Sep 2019	$132.60M	+99.6%
Jun 2019	$66.43M	+85.6%
Mar 2019	$35.79M	+98.2%
Dec 2018	$18.05M	-45.1%
Sep 2018	$32.90M	-3.8%
Jun 2018	$34.21M	0.0%
Mar 2018	$34.21M	0.0%
Dec 2017	$34.21M	>+9,900.0%
Sep 2017	$0.00	0.0%
Jun 2017	$0.00	0.0%
Mar 2017	$0.00	0.0%
Dec 2016	$0.00	0.0%
Sep 2016	$0.00	0.0%
Jun 2016	$0.00	0.0%
Mar 2016	$0.00	0.0%
Dec 2015	$0.00	0.0%
Sep 2015	$0.00	0.0%
Jun 2015	$0.00	0.0%

Month	Value	Change
Mar 2015	$0.00	0.0%
Dec 2014	$0.00	0.0%
Sep 2014	$0.00	0.0%
Jun 2014	$0.00	0.0%
Mar 2014	$0.00	0.0%
Dec 2013	$0.00	0.0%
Sep 2013	$0.00	0.0%
Jun 2013	$0.00	-100.0%
Mar 2013	$18.28M	-50.3%
Dec 2012	$36.75M	-34.3%
Sep 2012	$55.96M	-25.9%
Jun 2012	$75.49M	+31.9%
Mar 2012	$57.21M	+47.7%
Dec 2011	$38.75M	-1.7%
Sep 2011	$39.43M	+98.1%
Jun 2011	$19.90M	0.0%
Mar 2011	$19.90M	0.0%
Dec 2010	$19.90M	>+9,900.0%
Sep 2010	$0.00	0.0%
Jun 2010	$0.00	0.0%
Mar 2010	$0.00	0.0%
Dec 2009	$0.00	0.0%
Sep 2009	$0.00	0.0%
Jun 2009	$0.00	0.0%
Mar 2009	$0.00	0.0%
Dec 2008	$0.00	0.0%
Sep 2008	$0.00	0.0%
Jun 2008	$0.00	0.0%
Mar 2008	$0.00	0.0%
Dec 2007	$0.00	0.0%
Sep 2007	$0.00	0.0%
Jun 2007	$0.00	0.0%
Mar 2007	$0.00	0.0%
Dec 2006	$0.00	0.0%
Sep 2006	$0.00	0.0%
Jun 2006	$0.00	0.0%
Mar 2006	$0.00	0.0%
Dec 2005	$0.00	0.0%
Sep 2005	$0.00	0.0%
Jun 2005	$0.00	0.0%
Mar 2005	$0.00	0.0%
Dec 2004	$0.00	0.0%
Sep 2004	$0.00	0.0%
Jun 2004	$0.00	0.0%
Mar 2004	$0.00	-

FAQ

What is the current TTM gross profit of ALNY?: As of today, ALNY TTM gross profit is $3.83B
What is ALNY TTM gross profit most recent change?: ALNY TTM gross profit was up +10.44% on June 30, 2026
What is 1-year change in ALNY TTM gross profit?: ALNY TTM gross profit is up +85.83% year-over-year
How far is ALNY TTM gross profit from its all-time high?: ALNY TTM gross profit is currently at its all-time high
How does ALNY TTM gross profit rank versus sector peers?: ALNY TTM gross profit is higher than 95.54% of companies in Healthcare sector
When is ALNY next earnings release?: The next earnings release for ALNY is on October 29, 2026

Gross Profit Formula

Gross Profit = Revenue −

Data Sources & References

ALNY Official Website www.alnylam.com
Most Recent Annual Report (10-K) www.sec.gov/Archives/edgar/data/1178670/000162828026007497/0001628280-26-007497-index.htm
ALNY Profile on Yahoo Finance finance.yahoo.com/quote/ALNY
ALNY Profile on NASDAQ.com www.nasdaq.com/market-activity/stocks/alny